DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14642 and F12

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001014028.1	Gene:	F12 / 306761	RGDID:	1359175	Length:	603	Species:	Rattus norvegicus

Alignment Length:	359	Identity:	95/359 - (26%)
Similarity:	134/359 - (37%)	Gaps:	98/359 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 QFDRVEGPTQPKPKPRQYPPPPMPGQP-FPPPPGGFKKKENKQR-------RLCEQKYSE---YV 125
            |...:..|..|:......|.||:...| ||............|.       .:|.|::.:   .:
  Rat   295 QMPTLTSPVSPESHDMLKPRPPILQMPQFPSLSDALDNSTRNQNVVSRTSTVVCGQRFRKRLSSL 359

  Fly   126 ERIFPNDTAVAADANDADFDGRVLARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHC 190
            .|:.                |.::|.||.:|::||:.:.      |..|.||||...:|||||||
  Rat   360 RRVV----------------GGLVALPGSHPYIAALYWG------DSFCAGSLIDPCWVLTAAHC 402

  Fly   191 TSIYEAPPKWVRIGDLDLASEKRSVE-AQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVE---- 250
            .....||.:...:  |......:|.| .|.|.:.....|..:..|.|..|:|||:|.....
  Rat   403 LQKRPAPEELTVV--LGQDRHNQSCERCQTLAVHSYRLHEGFSSKTYQHDLALLRLRGRKNSCAI 465

  Fly   251 LTEYVRPVRL--WVFPELPTTIAFAMGY-----GATSFAKPMTNRLTNLNLTVVP---------- 298
            |:.:|:||.|  ...|...|.:....|:     ||..:|       |.|....||
  Rat   466 LSPHVQPVCLPSSAAPPSETVLCEVAGWGHQFEGAEEYA-------TFLQEAQVPFISLDRCSSS 523

  Fly   299 NAECNAELPPLAETPSGVLESQICAQDYILNRDTCQGDSGGPL---------QLNLPGRRRGHRI 354
            |...:|.||           ..:||.......|.|||||||||         ||.|.
  Rat   524 NVHGDAILP-----------GMLCAGFLEGGADACQGDSGGPLVCDEGVTERQLTLR-------- 569

  Fly   355 HYHLIGITSYGVFCRS-SYPSVYTRVSSFLDWIE 387
                 |:.|:|..|.. :.|.|||.|:::||||:
  Rat   570 -----GVISWGSGCGDRNKPGVYTDVANYLDWIQ 598

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	81/272 (30%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	80/271 (30%)
F12	NP_001014028.1	FN2	40..87	CDD:238019
		EGF_CA	95..130	CDD:238011
		FN1	132..170	CDD:238018
		EGF	177..207	CDD:278437
		Kringle	216..294	CDD:278480
		Tryp_SPc	361..597	CDD:214473	81/290 (28%)
		Tryp_SPc	362..600	CDD:238113	82/292 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910