DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and HABP2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_004123.1	Gene:	HABP2 / 3026	HGNCID:	4798	Length:	560	Species:	Homo sapiens

Alignment Length:	364	Identity:	104/364 - (28%)
Similarity:	161/364 - (44%)	Gaps:	107/364 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 RDIVFPELDAGPGKPEEKMWFHITDFQFDRVEGPTQPKPKPRQYPPPPMPGQPFPPPPGGFK--- 107
            :|:.:||                        |.||:|..|        :|         ||.
Human   279 QDVAYPE------------------------ESPTEPSTK--------LP---------GFDSCG 302

  Fly   108 KKENKQRRLCEQKYSEYVERIFPNDTAVAADANDADFDGRVLARPGEYPHMAA------VGFESD 166
            |.|..:|:         ::||:                |...:..|::|..|:      :.....
Human   303 KTEIAERK---------IKRIY----------------GGFKSTAGKHPWQASLQSSLPLTISMP 342

  Fly   167 RGQVDYKCGGSLISERFVLTAAHCTSIYEAPPKWVRIGDLDLASEKRSVEAQLLRIEQVF--AHP 229
            :|   :.|||:||...:||||||||.|.....| |.:||.||  :|.....|..|:|::|  :|.
Human   343 QG---HFCGGALIHPCWVLTAAHCTDIKTRHLK-VVLGDQDL--KKEEFHEQSFRVEKIFKYSHY 401

  Fly   230 NYKKKMYYDDIALLKLEKEVE-----LTEYVRPVRL--WVFPELPTTIAFAMGYGATSFAKPMTN 287
            |.:.::.::||||||| |.|:     .::||:.|.|  ..||.  .:.....|:|.|...|. :.
Human   402 NERDEIPHNDIALLKL-KPVDGHCALESKYVKTVCLPDGSFPS--GSECHISGWGVTETGKG-SR 462

  Fly   288 RLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYIL-NRDTCQGDSGGPLQLNLPGRRRG 351
            :|.:..:.::.|..||:.  .|.:  ..:.:|.|||.:... .:|||||||||||.....|.
Human   463 QLLDAKVKLIANTLCNSR--QLYD--HMIDDSMICAGNLQKPGQDTCQGDSGGPLTCEKDGT--- 520

  Fly   352 HRIHYHLIGITSYGVFCRSSYPSVYTRVSSFLDWIELTV 390
                |::.||.|:|:.| ...|.|||:|:.||:||:.|:
Human   521 ----YYVYGIVSWGLEC-GKRPGVYTQVTKFLNWIKATI 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	86/256 (34%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	85/255 (33%)
HABP2	NP_004123.1	EGF	77..106	CDD:306513
		KR	191..277	CDD:238056
		Tryp_SPc	314..553	CDD:238113	88/276 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910