DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and F2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	479	Identity:	114/479 - (23%)
Similarity:	175/479 - (36%)	Gaps:	183/479 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 NLSVCLISFIGLWCLS----NTHT----QRLPPEGRMRPLQDDSIRSPVDRDIVFPELDAGPGKP 60
            ||:|   :.:|..||:    .|.|    |...||.:   |..:..|:| |||
  Rat   226 NLAV---TTLGSPCLAWDSLPTKTLSKYQNFDPEVK---LVQNFCRNP-DRD------------- 270

  Fly    61 EEKMWFHITDFQFDRVEGPTQPKPKPRQYPPPPMPGQPFPPPPGGFKKKENKQRRLCEQKYSEYV 125
            ||..|..:..                          ||      ||:        .|...|.:..
  Rat   271 EEGAWCFVAQ--------------------------QP------GFE--------YCSLNYCDEA 295

  Fly   126 --ERIFPNDTAVAADANDADF----------------------------------------DGRV 148
              |.....|.::|....||:|                                        |||:
  Rat   296 VGEENHDGDESIAGRTTDAEFHTFFDERTFGLGEADCGLRPLFEKKSLTDKTEKELLDSYIDGRI 360

  Fly   149 LARPGEYPHMAAVGFESDRGQVDYK------------CGGSLISERFVLTAAHCTSIYEAPPKW- 200
            :.           |:::::|...::            ||.||||:|:|||||||. :|   |.|
  Rat   361 VE-----------GWDAEKGIAPWQVMLFRKSPQELLCGASLISDRWVLTAAHCI-LY---PPWD 410

  Fly   201 ---------VRIGDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYD-DIALLKLEKEVELTEYV 255
                     ||||.......:|:|| ::..:|:::.||.|..:...| |||||||:|.|..::|:
  Rat   411 KNFTENDLLVRIGKHSRTRYERNVE-KISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYI 474

  Fly   256 RPVRLWVFPELPTTIAF--------AMGYG------ATSFAKPMTNRLTNLNLTVVPNAECNAEL 306
            .||.|   |:..|..:.        ..|:|      .|:..:...:.|..:||.:|....|.
  Rat   475 HPVCL---PDKQTVTSLLQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCK--- 533

  Fly   307 PPLAETPSGVLESQICAQDYILN----RDTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVF 367
               |.|...:.::..|| .:.:|    .|.|:||||||..:..|...|     ::.:||.|:|..
  Rat   534 ---ASTRIRITDNMFCA-GFKVNDTKRGDACEGDSGGPFVMKSPYNHR-----WYQMGIVSWGEG 589

  Fly   368 C-RSSYPSVYTRVSSFLDWIELTV 390
            | |:.....||.|.....|::..:
  Rat   590 CDRNGKYGFYTHVFRLKRWMQKVI 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	81/282 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	80/281 (28%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480	25/125 (20%)
		Thrombin_light	312..359	CDD:286482	4/46 (9%)
		Tryp_SPc	359..608	CDD:214473	79/279 (28%)
		Tryp_SPc	360..612	CDD:238113	79/282 (28%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910