DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and TMPRSS11E

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_054777.2	Gene:	TMPRSS11E / 28983	HGNCID:	24465	Length:	423	Species:	Homo sapiens

Alignment Length:	242	Identity:	70/242 - (28%)
Similarity:	113/242 - (46%)	Gaps:	33/242 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 GEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYEAPPKWVRIGDLDLASEKRSVEA 217
            ||:|..|::.::.     .::||.:||:..::::||||.:.|:.|.:|.       ||...:::.
Human   201 GEWPWQASLQWDG-----SHRCGATLINATWLVSAAHCFTTYKNPARWT-------ASFGVTIKP 253

  Fly   218 QLLR--IEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPVRLWVFPEL-----PTTIAFAMG 275
            ..::  :.::..|..||...:..||:|.:|...|..|..|..|.|   |:.     |..:.|..|
Human   254 SKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCL---PDASYEFQPGDVMFVTG 315

  Fly   276 YGATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYILNRDTCQGDSGGP 340
            :||........|.|....:|::....||   .|.|.. ..:....:||.......|.||||||||
Human   316 FGALKNDGYSQNHLRQAQVTLIDATTCN---EPQAYN-DAITPRMLCAGSLEGKTDACQGDSGGP 376

  Fly   341 LQLNLPGRRRGHRIHYHLIGITSYGVFC-RSSYPSVYTRVSSFLDWI 386
            |..:      ..|..::|.||.|:|..| :.:.|.|||||::..|||
Human   377 LVSS------DARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	70/242 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	68/240 (28%)
TMPRSS11E	NP_054777.2	SEA	51..156	CDD:307516
TMPRSS11E	NP_054777.2	Tryp_SPc	192..420	CDD:238113	70/242 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910