DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and PRSS54

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001073961.1	Gene:	PRSS54 / 221191	HGNCID:	26336	Length:	395	Species:	Homo sapiens

Alignment Length:	266	Identity:	51/266 - (19%)
Similarity:	89/266 - (33%)	Gaps:	75/266 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 DFDGRVLARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYEAPPKWVRIGDLD 207
            :|...|..:..:|.|:|.               |.::||.:||:.|  ::|.......|.:|..:
Human    52 EFPWVVSLQDSQYTHLAF---------------GCILSEFWVLSIA--SAIQNRKDIVVIVGISN 99

  Fly   208 LASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPV-------------- 258
            :...|  :......:..:..|.::......::|||||.:..:.....|:.:
Human   100 MDPSK--IAHTEYPVNTIIIHEDFDNNSMSNNIALLKTDTAMHFGNLVQSICFLGRMLHTPPVLQ 162

  Fly   259 RLWVFPELPTTIAFAMGYGATS--FAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQI 321
            ..||....||:   |.|...|.  ..|.....|....|..:...||.:......:|
Human   163 NCWVSGWNPTS---ATGNHMTMSVLRKIFVKDLDMCPLYKLQKTECGSHTKEETKT--------- 215

  Fly   322 CAQDYILNRDTCQGDSGGPL-----QLNLPGRRRGHRIHYHLIGITSY-GVFCRSSYPSVYTRVS 380
                      .|.||.|.|:     |.:|          :.|.|:.:: |..|...:  :||:|.
Human   216 ----------ACLGDPGSPMMCQLQQFDL----------WVLRGVLNFGGETCPGLF--LYTKVE 258

  Fly   381 SFLDWI 386
            .:..||
Human   259 DYSKWI 264

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	50/263 (19%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	48/261 (18%)
PRSS54	NP_001073961.1	Tryp_SPc	52..264	CDD:214473	49/264 (19%)
		Tryp_SPc	52..264	CDD:238113	49/264 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	324..348
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910