DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and F11

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_005262878.1	Gene:	F11 / 2160	HGNCID:	3529	Length:	626	Species:	Homo sapiens

Alignment Length:	408	Identity:	108/408 - (26%)
Similarity:	155/408 - (37%)	Gaps:	81/408 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 CLSNTHTQRLPPE--GRMRPLQDDSIRS-----PV--------DRDIVFPELDAGPGKPEE---K 63
            ||..|....||..  .:.:.|...|::|     ||        |.|.:..|||....|..|   |
Human   255 CLLKTSESGLPSTRIKKSKALSGFSLQSCRHSIPVFCHSSFYHDTDFLGEELDIVAAKSHEACQK 319

  Fly    64 MWFHITDFQF-----------DRVEGPTQPKPKPRQYPPPPMPGQPFPPPPGGFKKKENKQRRLC 117
            :..:....||           :...|....|......|...:.|:      ||.   .....|||
Human   320 LCTNAVRCQFFTYTPAQASCNEGNRGKCYLKLSSNGSPTKILHGR------GGI---SGYTLRLC 375

  Fly   118 EQKYSEYVERIFPNDTAVAADANDADFDGRVLARPGEYPHMAAVGFESDRGQVDYKCGGSLISER 182
            :.. :|...:|.|......|...            ||:|....:...|...:  :.||||:|..:
Human   376 KMD-NECTTKIKPRIVGGTASVR------------GEWPWQVTLHTTSPTQR--HLCGGSIIGNQ 425

  Fly   183 FVLTAAHCTSIYEAPPKWVRIGDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEK 247
            ::||||||....|: ||.:|:....|...:...:.....::::..|..||......||||||||.
Human   426 WILTAAHCFYGVES-PKILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLET 489

  Fly   248 EVELTEYVRPVRLWVFPELPT--------TIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECNA 304
            .|..|:..||:.      ||:        |..:..|:|.......:.|.|....:.:|.|.||..
Human   490 TVNYTDSQRPIC------LPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKIPLVTNEECQK 548

  Fly   305 ELPPLAETPSGVLESQICAQDYILNRDTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFC- 368
            ..     ....:....|||......:|.|:|||||||...       |...:||:||||:|..|
Human   549 RY-----RGHKITHKMICAGYREGGKDACKGDSGGPLSCK-------HNEVWHLVGITSWGEGCA 601

  Fly   369 RSSYPSVYTRVSSFLDWI 386
            :...|.|||.|..::|||
Human   602 QRERPGVYTNVVEYVDWI 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	75/250 (30%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	73/248 (29%)
F11	XP_005262878.1	APPLE	20..103	CDD:128519
		APPLE	110..193	CDD:128519
		APPLE	200..283	CDD:128519	7/27 (26%)
		APPLE	291..375	CDD:128519	17/92 (18%)
		Tryp_SPc	388..619	CDD:214473	74/263 (28%)
		Tryp_SPc	389..619	CDD:238113	74/262 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910