DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and F2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_000497.1	Gene:	F2 / 2147	HGNCID:	3535	Length:	622	Species:	Homo sapiens

Alignment Length:	403	Identity:	102/403 - (25%)
Similarity:	154/403 - (38%)	Gaps:	119/403 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    57 PGKPEEKMWFHIT----DFQF----------------------DR-VEGPTQPKPKPRQYPPPPM 94
            |...||.:|.::.    ||.:                      || :||.|........:.|...
Human   265 PDGDEEGVWCYVAGKPGDFGYCDLNYCEEAVEEETGDGLDEDSDRAIEGRTATSEYQTFFNPRTF 329

  Fly    95 PG-------QPFPPPPGGFKKK--ENKQRRLCEQKYSEYVERIFPNDTAVAADANDADFDGRVL- 149
            ..       :|.      |:||  |:|..|...:.|                      .|||::
Human   330 GSGEADCGLRPL------FEKKSLEDKTERELLESY----------------------IDGRIVE 366

  Fly   150 ---ARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYEAPPKW----------V 201
               |..|..|....:..:|.:   :..||.||||:|:|||||||. :|   |.|          |
Human   367 GSDAEIGMSPWQVMLFRKSPQ---ELLCGASLISDRWVLTAAHCL-LY---PPWDKNFTENDLLV 424

  Fly   202 RIGDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYD-DIALLKLEKEVELTEYVRPVRLWVFPE 265
            |||.......:|::| ::..:|:::.||.|..:...| ||||:||:|.|..::|:.||.|   |:
Human   425 RIGKHSRTRYERNIE-KISMLEKIYIHPRYNWRENLDRDIALMKLKKPVAFSDYIHPVCL---PD 485

  Fly   266 LPTTIAF--------AMGYG------ATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGV 316
            ..|..:.        ..|:|      ..:..|...:.|..:||.:|....|.      ..|...:
Human   486 RETAASLLQAGYKGRVTGWGNLKETWTANVGKGQPSVLQVVNLPIVERPVCK------DSTRIRI 544

  Fly   317 LESQICA---QDYILNRDTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFC-RSSYPSVYT 377
            .::..||   .|.....|.|:||||||..:..|...|     ::.:||.|:|..| |......||
Human   545 TDNMFCAGYKPDEGKRGDACEGDSGGPFVMKSPFNNR-----WYQMGIVSWGEGCDRDGKYGFYT 604

  Fly   378 RVSSFLDWIELTV 390
            .|.....||:..:
Human   605 HVFRLKKWIQKVI 617

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	80/273 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	79/272 (29%)
F2	NP_000497.1	GLA	25..88	CDD:214503
		KR	105..186	CDD:238056
		KR	211..293	CDD:214527	6/27 (22%)
		Thrombin_light	317..363	CDD:286482	10/73 (14%)
		Tryp_SPc	363..613	CDD:214473	78/271 (29%)
		Tryp_SPc	364..616	CDD:238113	79/273 (29%)
		High affinity receptor-binding region which is also known as the TP508 peptide	551..573		10/21 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910