DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and Hpn

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_001263198.1	Gene:	Hpn / 15451	MGIID:	1196620	Length:	445	Species:	Mus musculus

Alignment Length:	264	Identity:	76/264 - (28%)
Similarity:	111/264 - (42%)	Gaps:	65/264 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   153 GEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHC-TSIYEAPPKW-VRIGDLDLASEKRSV 215
            |.:|...::.::.     .:.|||||:|..:||||||| ........:| |..|    |..:.|.
Mouse   200 GRWPWQVSLRYDG-----THLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFAG----AVARTSP 255

  Fly   216 EAQLLRIEQVFAHPNYKKKMYYD--------DIALLKLEKEVELTEYVRPVRLWVFPELPTT--- 269
            .|..|.::.|..|..|..  :.|        ||||:.|...:.||||::||.      ||..
Mouse   256 HAVQLGVQAVIYHGGYLP--FRDPTIDENSNDIALVHLSSSLPLTEYIQPVC------LPAAGQA 312

  Fly   270 -----IAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECNA------ELPP---LAETPSGVLESQ 320
                 :....|:|.|.|.......|....:.::.|..||:      ::.|   .|..|.|.:
Mouse   313 LVDGKVCTVTGWGNTQFYGQQAMVLQEARVPIISNEVCNSPDFYGNQIKPKMFCAGYPEGGI--- 374

  Fly   321 ICAQDYILNRDTCQGDSGGPL--QLNLPGRRRGHRIHYHLIGITSYGVFCR-SSYPSVYTRVSSF 382
                      |.||||||||.  :.::.|..|     :.|.||.|:|..|. :..|.|||:|:.|
Mouse   375 ----------DACQGDSGGPFVCEDSISGTSR-----WRLCGIVSWGTGCALARKPGVYTKVTDF 424

  Fly   383 LDWI 386
            .:||
Mouse   425 REWI 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	76/264 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	74/262 (28%)
Hpn	NP_001263198.1	Hepsin-SRCR	78..187	CDD:255261
		Tryp_SPc	190..428	CDD:214473	74/262 (28%)
		Tryp_SPc	191..428	CDD:238113	74/262 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000