DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and F2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	NP_034298.1	Gene:	F2 / 14061	MGIID:	88380	Length:	618	Species:	Mus musculus

Alignment Length:	372	Identity:	95/372 - (25%)
Similarity:	146/372 - (39%)	Gaps:	123/372 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PGGFKKKENKQRRLCEQKYSEYV--ERIFPNDTAVAADANDADF--------------------- 144
            ||.|:        .|...|.|..  |..:..|.::|....||:|
Mouse   282 PGDFE--------YCNLNYCEEAVGEENYDVDESIAGRTTDAEFHTFFNEKTFGLGEADCGLRPL 338

  Fly   145 -------------------DGRVLARPGEYPHMAAVGFESDRGQVDYK------------CGGSL 178
                               |||::.           |:::::|...::            ||.||
Mouse   339 FEKKSLKDTTEKELLDSYIDGRIVE-----------GWDAEKGIAPWQVMLFRKSPQELLCGASL 392

  Fly   179 ISERFVLTAAHCTSIYEAPPKW----------VRIGDLDLASEKRSVEAQLLRIEQVFAHPNYKK 233
            ||:|:|||||||. :|   |.|          ||||.......:|:|| ::..:|:::.||.|..
Mouse   393 ISDRWVLTAAHCI-LY---PPWDKNFTENDLLVRIGKHSRTRYERNVE-KISMLEKIYVHPRYNW 452

  Fly   234 KMYYD-DIALLKLEKEVELTEYVRPVRLWVFPELPTTIAF--------AMGYG------ATSFAK 283
            :...| |||||||:|.|..::|:.||.|   |:..|..:.        ..|:|      .|:..:
Mouse   453 RENLDRDIALLKLKKPVPFSDYIHPVCL---PDKQTVTSLLRAGYKGRVTGWGNLRETWTTNINE 514

  Fly   284 PMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYILN----RDTCQGDSGGPLQLN 344
            ...:.|..:||.:|....|.      |.|...:.::..|| .:.:|    .|.|:||||||..:.
Mouse   515 IQPSVLQVVNLPIVERPVCK------ASTRIRITDNMFCA-GFKVNDTKRGDACEGDSGGPFVMK 572

  Fly   345 LPGRRRGHRIHYHLIGITSYGVFC-RSSYPSVYTRVSSFLDWIELTV 390
            .|...|     ::.:||.|:|..| |......||.|.....||:..:
Mouse   573 SPFNNR-----WYQMGIVSWGEGCDRKGKYGFYTHVFRLKRWIQKVI 614

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	81/282 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	80/281 (28%)
F2	NP_034298.1	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		KR	213..295	CDD:214527	5/20 (25%)
		Thrombin_light	313..360	CDD:286482	4/46 (9%)
		Tryp_SPc	360..610	CDD:214473	79/280 (28%)
		Tryp_SPc	361..613	CDD:238113	80/282 (28%)
		High affinity receptor-binding region which is also known as the TP508 peptide. /evidence=ECO:0000250	548..570		10/22 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910