DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and tmprss2.2

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_002941330.2	Gene:	tmprss2.2 / 100493729	XenbaseID:	XB-GENE-22065949	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	345	Identity:	88/345 - (25%)
Similarity:	129/345 - (37%)	Gaps:	111/345 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 PFPPPPGGFKKKEN-----------------------KQRRL-CEQKYSEYVERIFPNDTAVAAD 138
            |.|..|.|:.|..|                       ..|.: |...|:....||.
Frog   228 PSPYAPNGYFKLNNGFGSSQFYTSVQNSSSCFSGNVVSLRCISCGVSYNSVASRIV--------- 283

  Fly   139 ANDADFDGRVLARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHCTSIYE------AP 197
                   |...|..|.:  :..||...:.|.:   ||||:||.::::|||||  :|.      :.
Frog   284 -------GGTYAAYGNW--LWQVGLRYNTGIL---CGGSIISPKWIVTAAHC--VYGTDGFLLSA 334

  Fly   198 PKW-VRIGDLDLASEKRSVEAQLLRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTEYVRPVRL- 260
            ..| |..|.|.|.|   ..::....:|::..||.||.....:||||::|...:......:||.|
Frog   335 SGWRVFAGTLTLPS---YYDSSGYLVERIIPHPGYKTSSNDNDIALMELSNGITFGYNTQPVCLP 396

  Fly   261 -----WVFPELPTTIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQ 320
                 |    ...|..:..|:|.||.....:   |.|....|.                 :::|.
Frog   397 NAGMFW----SSGTPCWISGWGTTSQGGSAS---TYLQYAAVQ-----------------LIDSN 437

  Fly   321 ICAQDYILNR----------------DTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFC- 368
            :|.|:|:.|.                |:|||||||||.....|.       :.|:|.||:|..|
Frog   438 VCNQNYVYNGQITASMICAGYLSGGVDSCQGDSGGPLVTKTNGT-------WWLVGDTSWGYGCA 495

  Fly   369 RSSYPSVYTRVSSFLDWIEL 388
            :.:.|.||..::|||.||.|
Frog   496 QPNKPGVYGNMTSFLGWIYL 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	75/270 (28%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	74/269 (28%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060
		LDLa	145..174	CDD:238060
		SRCR_2	179..274	CDD:292133	8/45 (18%)
		Tryp_SPc	281..513	CDD:214473	76/288 (26%)
		Tryp_SPc	282..513	CDD:238113	75/287 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000