DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14642 and tmprss6

DIOPT Version :9

Sequence 1:	NP_001246901.1	Gene:	CG14642 / 40532	FlyBaseID:	FBgn0037222	Length:	392	Species:	Drosophila melanogaster
Sequence 2:	XP_004913946.2	Gene:	tmprss6 / 100489045	XenbaseID:	XB-GENE-1011573	Length:	806	Species:	Xenopus tropicalis

Alignment Length:	253	Identity:	75/253 - (29%)
Similarity:	127/253 - (50%)	Gaps:	34/253 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 GRVLARPGEYPHMAAVGFESDRGQVDYKCGGSLISERFVLTAAHC--TSIYEAPPKW-VRIGDLD 207
            |...|:.||:|..|::   ..||  ::.|||:|::::::||||||  ...|.:|..| |.:|.:.
Frog   573 GGTQAQEGEWPWQASL---QVRG--EHICGGTLVADQWILTAAHCFTPESYASPEVWTVYLGKVR 632

  Fly   208 LASEKRSVEAQL-LRIEQVFAHPNYKKKMYYDDIALLKLEKEVELTE-YVRPVRLWVFP----EL 266
            |:   ||.:.:| .::.::..||.|.:..:..|:||:.|:..|.||. :|:|:.|   |    ..
Frog   633 LS---RSTQKELAFKVIRLVIHPFYDEDSHDYDVALVLLDHLVPLTSPHVQPICL---PSSTHHF 691

  Fly   267 PT-TIAFAMGYGATSFAKPMTNRLTNLNLTVVPNAECNAELPPLAETPSGVLESQICAQDYILNR 330
            || :..:..|:|:.....|.::.|..:::.:|....| .||.....:|     ..:||.....::
Frog   692 PTGSSCWVTGWGSVKENGPTSDVLQKVDIQLVAQDIC-TELYRYQISP-----RMLCAGYRDGSK 750

  Fly   331 DTCQGDSGGPLQLNLPGRRRGHRIHYHLIGITSYGVFCR-SSYPSVYTRVSSFLDWIE 387
            |.||||||.||.......|      :...|:.|:|..|. ..|..||:|::..:.|||
Frog   751 DACQGDSGSPLVCKTASGR------WFQAGLVSWGAGCGIPRYFGVYSRITRLVQWIE 802

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14642	NP_001246901.1	Tryp_SPc	146..387	CDD:238113	73/251 (29%)
CG14642	NP_001246901.1	Tryp_SPc	146..386	CDD:214473	72/250 (29%)
tmprss6	XP_004913946.2	SEA	77..176	CDD:396113
		CUB	235..303	CDD:412131
		LDLa	448..478	CDD:238060
		LDLa	480..514	CDD:238060
		LDLa	525..560	CDD:238060
		Tryp_SPc	572..804	CDD:238113	75/253 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910