DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abs and DDX23

DIOPT Version :9

Sequence 1:	NP_524220.1	Gene:	abs / 40530	FlyBaseID:	FBgn0015331	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_004809.2	Gene:	DDX23 / 9416	HGNCID:	17347	Length:	820	Species:	Homo sapiens

Alignment Length:	621	Identity:	203/621 - (32%)
Similarity:	317/621 - (51%)	Gaps:	83/621 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 KRYRRSSKSSEEGDLD-NEDYVPYVPVKERKKQ----HMIKLGRIVQLVSETAQPKSSSENE--- 61
            :|.||..:...|.:.: |||......::|.|.:    |.|| .|.:..:.:..:.:..::.:
Human   211 ERERRERRERMERETNGNEDEEGRQKIREEKDKSKELHAIK-ERYLGGIKKRRRTRHLNDRKFVF 274

  Fly    62 ----NEDDS-------QGAHDVETWGRKYNISLLDQHTELKKIAEAKKLSAVEKQLREEEKIMES 115
                :||.|       :..|.|:..||.:...:     :||:  :.::.|.....|.|:.:.:|.
Human   275 EWDASEDTSIDYNPLYKERHQVQLLGRGFIAGI-----DLKQ--QKREQSRFYGDLMEKRRTLEE 332

  Fly   116 IAQQKALMGVAELAKGIQYEQPIKTAWKPPRY----IREMSEEEREAVRHELRILVEGETPSPPI 176
            ..|::|.:  .:|.|     :..|..|....:    :.||::.:....|.:..|..:|.....||
Human   333 KEQEEARL--RKLRK-----KEAKQRWDDRHWSQKKLDEMTDRDWRIFREDYSITTKGGKIPNPI 390

  Fly   177 RSFREMKFPKGILNGLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALE 241
            ||:::...|..||..:...|.|.|||||.|.:|..|..||:||:|.||||||..|::|::::..
Human   391 RSWKDSSLPPHILEVIDKCGYKEPTPIQRQAIPIGLQNRDIIGVAETGSGKTAAFLIPLLVWIT- 454

  Fly   242 QEYSLP-----FERNEGPYGLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSE 301
               :||     .|.::|||.:|:.|:||||:|..|....:.|.|      .||:...:||:...:
Human   455 ---TLPKIDRIEESDQGPYAIILAPTRELAQQIEEETIKFGKPL------GIRTVAVIGGISRED 510

  Fly   302 ALDVISRGVHIVVATPGRLMDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIF-------- 358
            ....:..|..||:||||||:|:|:.:.|.|..|.|:.:||||||||||||.||:.|.
Human   511 QGFRLRMGCEIVIATPGRLIDVLENRYLVLSRCTYVVLDEADRMIDMGFEPDVQKILEHMPVSNQ 575

  Fly   359 ---------------SFFKGQ---RQTLLFSATMPKKIQNFARSALVKPVTINVGRAGAASMNVT 405
                           :|..|:   |||::|:||||..::..|||.|.:|..:.:|.||.....|.
Human   576 KPDTDEAEDPEKMLANFESGKHKYRQTVMFTATMPPAVERLARSYLRRPAVVYIGSAGKPHERVE 640

  Fly   406 QQVEYVKQEAKVVYLLDCL-QKTAPPVLIFAEKKQDVDCIHEYLLLKGVEAVAIHGGKDQEERSR 469
            |:|..:.:..|...||..| |...||::||..:|:..|.:.:.|...|..|..:||||.||:|..
Human   641 QKVFLMSESEKRKKLLAILEQGFDPPIIIFVNQKKGCDVLAKSLEKMGYNACTLHGGKGQEQREF 705

  Fly   470 AVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTLINK 534
            |:...:.|.||:|||||||.:|:|..:|..|:||||..:||:|:||||||||:...|:|.|.:.|
Human   706 ALSNLKAGAKDILVATDVAGRGIDIQDVSMVVNYDMAKNIEDYIHRIGRTGRAGKSGVAITFLTK 770

  Fly   535 TTEQSVLLDLKHLLIEGKQEVPDFLDELAPETEHQH 570
             .:.:|..:||..::|  ..|.....|||...:.||
Human   771 -EDSAVFYELKQAILE--SPVSSCPPELANHPDAQH 803

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abs	NP_524220.1	DEADc	179..393	CDD:238167	91/244 (37%)
		DEXDc	192..397	CDD:214692	89/235 (38%)
		Helicase_C	414..523	CDD:278689	51/109 (47%)
DDX23	NP_004809.2	RS domain	1..221		3/9 (33%)
		PTZ00121	<4..>351	CDD:173412	31/154 (20%)
		SF-CC1	80..>210	CDD:273721
		Q motif. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00552	391..419		11/27 (41%)
		DEADc_DDX23	402..628	CDD:350703	90/235 (38%)
		DEAD box. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00541	549..552		2/2 (100%)
		SF2_C_DEAD	639..768	CDD:350174	57/128 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.920