DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abs and PRP28

DIOPT Version :9

Sequence 1:	NP_524220.1	Gene:	abs / 40530	FlyBaseID:	FBgn0015331	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_010529.3	Gene:	PRP28 / 851830	SGDID:	S000002651	Length:	588	Species:	Saccharomyces cerevisiae

Alignment Length:	549	Identity:	159/549 - (28%)
Similarity:	271/549 - (49%)	Gaps:	58/549 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KERKKQHMIKLGR--IVQLVSETAQPKSSSENENEDDSQGAHDVETWGRKYNISLLDQHTELKKI 93
            :||.||..:|...  :....|::|:.:....|..:|                 |..::..:.|:.
Yeast    37 QERSKQERLKENEESLTPTQSDSAKVEIKKVNSRDD-----------------SFFNETNDKKRN 84

  Fly    94 AEAKKLSAVEKQLREEEKIMESIAQQKALMGVAELAKGIQYEQPIKTAWKPPRY----IREMSEE 154
            ...:..|.......|.|..:.......:...:..|.||...:...::::....:    :.||:|.
Yeast    85 PSKQNGSKFHFSWNESEDTLSGYDPIVSTRAIDLLWKGKTPKNAAESSYMGKHWTEKSLHEMNER 149

  Fly   155 EREAVRHELRILVEGETPSPPIRSFREMK-FPKGILNGLAAK-GIKNPTPIQVQGLPTVL---AG 214
            :...::.:..|:.:|.|...|:|::.|:. .|:.:|..:..: ...:|||||...:|.|.   ..
Yeast   150 DWRILKEDYAIVTKGGTVENPLRNWEELNIIPRDLLRVIIQELRFPSPTPIQRITIPNVCNMKQY 214

  Fly   215 RDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLP----FERNEGPYGLIICPSRELA----KQTHE 271
            ||.:|:|.|||||||.||:|::   ::...|.|    .:..:||..||:.|:|||.    |:|.:
Yeast   215 RDFLGVASTGSGKTLAFVIPIL---IKMSRSPPRPPSLKIIDGPKALILAPTRELVQQIQKETQK 276

  Fly   272 IIQHYSKHLQ-ACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRLMDMLDKKILTLDMCR 335
            :.:.:||... .|.:..|     :||..:.|....:|.|..|:|||||||:|.|:..:|.:....
Yeast   277 VTKIWSKESNYDCKVISI-----VGGHSLEEISFSLSEGCDILVATPGRLIDSLENHLLVMKQVE 336

  Fly   336 YLCMDEADRMIDMGFEEDVRTIFSFF------KGQRQTLLFSATMPKKIQNFARSALVKPVTINV 394
            .|.:||||:|||:|||:.|..|.:..      ...||||:|:|||...|:..|...:.|||...:
Yeast   337 TLVLDEADKMIDLGFEDQVTNILTKVDINADSAVNRQTLMFTATMTPVIEKIAAGYMQKPVYATI 401

  Fly   395 GRAGAASMNVTQQVEYV-KQEAKVVYLLDCLQKTAPPVLIFAEKKQDVDCIHE-YLLLKGVEAVA 457
            |....:...:.|.|||. ..|.|...|...:.|..||::||...||..|.:.| :.....::...
Yeast   402 GVETGSEPLIQQVVEYADNDEDKFKKLKPIVAKYDPPIIIFINYKQTADWLAEKFQKETNMKVTI 466

  Fly   458 IHGGKDQEERSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRS 522
            :||.|.||:|..::..:|..|..:::||:||::|||.|||..|:|:.:...:::|:||||||||:
Yeast   467 LHGSKSQEQREHSLQLFRTNKVQIMIATNVAARGLDIPNVSLVVNFQISKKMDDYIHRIGRTGRA 531

  Fly   523 NTKGLATTLINKTTEQSVLLDL-----KH 546
            ..:|.|.:.::...::|::.:|     ||
Yeast   532 ANEGTAVSFVSAAEDESLIRELYKYVRKH 560

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abs	NP_524220.1	DEADc	179..393	CDD:238167	82/233 (35%)
		DEXDc	192..397	CDD:214692	80/223 (36%)
		Helicase_C	414..523	CDD:278689	41/109 (38%)
PRP28	NP_010529.3	SrmB	143..580	CDD:223587	142/426 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910