Protein Alignment abs and DDX43

DIOPT Version :10

• Sequence 1: NP_524220.1
• Gene: abs / 40530
• FlyBaseID: FBgn0015331
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: XP_047274937.1
• Gene: DDX43 / 55510
• HGNCID: 18677
• Length: 653
• Species: Homo sapiens
• Alignment Length: 604
• Identity: 180/604 - (29%)
• Similarity: 293/604 - (48%)
• Gaps: 107/604 - (17%)

  Fly     6 RYRRSSKSSEEGDLDNEDYVPYVPVKERKKQHMI--KLGR--------------IVQLVSETAQP 54
            |:|.:|:..|.....:|:    :|:....|.|.:  .:||              .:|::.|  ||
Human    50 RWRGTSRPPEAVAAGHEE----LPLCFALKSHFVGAVIGRGGSKIKNIQSTTNTTIQIIQE--QP 108

  Fly    55 KSSSENENEDDSQGAHDVETWGRKYNISLLDQHTELKKIAE--AKKLS---------------AV 102
            :|.              |:.:|.|      ...|:.|.:.:  .|||.               :|
Human   109 ESL--------------VKIFGSK------AMQTKAKAVIDNFVKKLEENYNSECGIDTAFQPSV 153

  Fly   103 EKQLREEEKIMESIAQQKALMGVAEL-AKGIQYEQPIKTAWK--PP---RYIRE------MSEEE 155
            .|....:..:   :|..:.|:...:: .:|::::   ||.|.  ||   .:.:|      ||:.|
Human   154 GKDGSTDNNV---VAGDRPLIDWDQIREEGLKWQ---KTKWADLPPIKKNFYKESTATSAMSKVE 212

  Fly   156 REAVRHE-LRI----LVEGE-TPSP-PIRSFRE--MKFPKGILNGLAAKGIKNPTPIQVQGLPTV 211
            .::.|.| ..|    |.:|| .|.| |..:|.:  ..:|: ::..:...|.:.|||||.|..|.|
Human   213 ADSWRKENFNITWDDLKDGEKRPIPNPTCTFDDAFQCYPE-VMENIKKAGFQKPTPIQSQAWPIV 276

  Fly   212 LAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLPFERNEGPYGLIICPSRELAKQTHEIIQHY 276
            |.|.||||:|.||:||||.:::|..:..:.|. ||..:||. |..|::.|:||||.|.......|
Human   277 LQGIDLIGVAQTGTGKTLCYLMPGFIHLVLQP-SLKGQRNR-PGMLVLTPTRELALQVEGECCKY 339

  Fly   277 SKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRLMDMLDKKILTLDMCRYLCMDE 341
            |       ...:||....||....|.::.:.:||.|::||||||.|:.....:.|....||.:||
Human   340 S-------YKGLRSVCVYGGGNRDEQIEELKKGVDIIIATPGRLNDLQMSNFVNLKNITYLVLDE 397

  Fly   342 ADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATMPKKIQNFARSALVKPVTINVGRAG-AASMNVT 405
            ||:|:|||||..:..|....:..|||::.|||.|..:...|:|.|.:|:.:.||... .|..:|.
Human   398 ADKMLDMGFEPQIMKILLDVRPDRQTVMTSATWPHSVHRLAQSYLKEPMIVYVGTLDLVAVSSVK 462

  Fly   406 QQVEYVKQEAKVVYLLDCLQ--KTAPPVLIFAEKKQDVDCIHEYLLLKGVEAVAIHGGKDQEERS 468
            |.:....:|.|..::...||  .:...|::|..:|...|.:...|:|..:...::||.::|.:|.
Human   463 QNIIVTTEEEKWSHMQTFLQSMSSTDKVIVFVSRKAVADHLSSDLILGNISVESLHGDREQRDRE 527

  Fly   469 RAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTLIN 533
            :|::.::.||..:|:|||:||:|||..:|.||.|:|.|.:||.||||||||||:.        :.
Human   528 KALENFKTGKVRILIATDLASRGLDVHDVTHVYNFDFPRNIEEYVHRIGRTGRAG--------VF 584

  Fly   534 KTTEQSVLLDLKHLLIEGK 552
            :.:....|..|:|:..:||
Human   585 QRSLYQWLRGLRHINRKGK 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
abs	NP_524220.1	DEADc_DDX41	188..393	CDD:350709	78/204 (38%)
		SF2_C_DEAD	404..532	CDD:350174	46/129 (36%)
DDX43	XP_047274937.1	KH-I_DDX43_DDX53	69..134	CDD:411858	15/86 (17%)
		SrmB	242..>582	CDD:440279	129/349 (37%)