DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abs and CG8611

DIOPT Version :9

Sequence 1:	NP_524220.1	Gene:	abs / 40530	FlyBaseID:	FBgn0015331	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	NP_788922.1	Gene:	CG8611 / 32725	FlyBaseID:	FBgn0027602	Length:	975	Species:	Drosophila melanogaster

Alignment Length:	679	Identity:	164/679 - (24%)
Similarity:	281/679 - (41%)	Gaps:	176/679 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 KERKKQHMIKLG--RIVQLVSETAQPKSSSE---------------------NENEDDSQGAHDV 72
            |:|:.:.:.||.  :|.:.:....:||:.::                     .|...|.:.:.|.
  Fly   149 KQRQGKPLTKLSEEQITRALKSNKKPKNPNQLPTPGDLFRAQLEEERRQKRREEGGGDQEASADE 213

  Fly    73 E-----TWGRKYNISLLDQHTELKKIAEAKKLSAV-------EKQLREEEKIMESIAQQKALMGV 125
            |     :.|....:.      ....:.|:||.|.:       |:....:|:..||.||...
  Fly   214 EDAKNNSGGGSPRVK------PSSAVKESKKSSDIEDSGESGEESATSDEEPDESSAQSPG---- 268

  Fly   126 AELAKGIQYEQPIKTAWKPPRYIREMSEEEREAVRHELRIL-------VE-----GETPSPPIRS 178
                   |.::|.:||.|||:     :||.....|...:.:       ||     |:....|::.
  Fly   269 -------QEKEPKQTAKKPPK-----AEETSSTNRFRTKKIGLFDQSDVEALKQLGQRAVKPVKE 321

  Fly   179 --FREMKF------PKGILNGLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPV 235
              |...|.      |..:.|......|:..|.:|.:.:|.||.|:|::..:.|||||||.:.||:
  Fly   322 TIFTGSKISTLGLHPHAVKNLEDLLSIRELTSVQQKTIPEVLQGKDVLVRSQTGSGKTLAYALPL 386

  Fly   236 IMFALEQEYSLPFERNEGPYGLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVS 300
            :....:|:..:  :|.:|...|:|.|:|||..||:|:||...|..         :.:..|.|...
  Fly   387 VELLQKQQPRI--QRKDGVLALVIVPTRELVMQTYELIQKLVKPY---------TWIVPGSLLGG 440

  Fly   301 EALDV----ISRGVHIVVATPGRLMD-MLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSF 360
            |:...    :.:|::|::.|||||:| :|......|...::|.:|||||::::|:|.||:.:...
  Fly   441 ESRKSEKARLRKGINILIGTPGRLVDHLLHTASFKLTKLQFLILDEADRLLELGYERDVKQLVEA 505

  Fly   361 FKGQR-----------QTLLFSATMPKKIQNFARSALVKPVTI-NVGRAGAASM----------- 402
            ...||           |.:|.|||:..::|..|...|..|:.| |...|.:|::
  Fly   506 IDKQRAECEDKELPQLQRMLLSATLTSQVQQLAGLTLKNPLYIDNSDEAASAALKSKDGYQKETI 570

  Fly   403 ---------------NVT--------QQVEY--VKQEAKVVYLLDCLQK--TAPP----VLIFAE 436
                           :||        .|:.|  |..:.::|.|...|.|  .|.|    .::|..
  Fly   571 EALLEVDDGLGEYQEDVTGVLSIPENLQLSYVVVPPKLRLVALSSLLAKEVDASPKQFKAIVFMS 635

  Fly   437 KKQDVDCIHEYL---------------------------LLKGVEAVAIHGGKDQEERSRAVDAY 474
            ..:.|:..|:.|                           ||:|:....:||...|.||......:
  Fly   636 TTEMVNFHHDMLNEALTRRVLDEEDEQEKGDSDDDGDIPLLQGLRFFKLHGSMTQTERQGVFRGF 700

  Fly   475 RVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTLINKTTEQS 539
            |.....||:||||..:|:|.|:::.|:.|..|....::|||:|||.|:..||.|...:..:..|.
  Fly   701 RDCASCVLLATDVVGRGIDVPDIKLVVQYTPPQTTADFVHRVGRTARAGRKGRAVLFLTPSEAQF 765

  Fly   540 VL-LDLKHLLIEGKQEVPDFLDELAPETE 567
            |. |:.|.:.|: :.::..:|..|.|:.:
  Fly   766 VRHLEKKRIRIQ-QGDMYAYLQTLLPKDD 793

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abs	NP_524220.1	DEADc	179..393	CDD:238167	71/236 (30%)
		DEXDc	192..397	CDD:214692	68/221 (31%)
		Helicase_C	414..523	CDD:278689	38/141 (27%)
CG8611	NP_788922.1	DUF2413	203..>285	CDD:287302	21/103 (20%)
		P-loop_NTPase	332..548	CDD:304359	68/226 (30%)
		DEXDc	348..554	CDD:214692	68/216 (31%)
		HELICc	601..757	CDD:238034	43/155 (28%)
		DUF4217	805..866	CDD:290667
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451625
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930