DRSC/TRiP Functional Genomics Resources

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Protein Alignment abs and DDX42

DIOPT Version :10

Sequence 1:NP_524220.1 Gene:abs / 40530 FlyBaseID:FBgn0015331 Length:619 Species:Drosophila melanogaster
Sequence 2:NP_031398.2 Gene:DDX42 / 11325 HGNCID:18676 Length:938 Species:Homo sapiens


Alignment Length:649 Identity:212/649 - (32%)
Similarity:320/649 - (49%) Gaps:89/649 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 EEGDLDNEDYVPYVPVKE---RKKQHMIKLGRIVQLVSETAQPKSSSENEN-------EDDSQGA 69
            ||.|..|.| :||:|.:.   |::.|              ::|..|..:::       |.:.|.|
Human    79 EEEDSSNVD-LPYIPAENSPTRQQFH--------------SKPVDSDSDDDPLEAFMAEVEDQAA 128

  Fly    70 HDVETWGRK----YNISLL--------DQHTELKKIAEAKKLSAVEKQLREEEKIME------SI 116
            .|::....|    .|:..:        ||....:.:||......|::   |||..:|      .|
Human   129 RDMKRLEEKDKERKNVKGIRDDIEEEDDQEAYFRYMAENPTAGVVQE---EEEDNLEYDSDGNPI 190

  Fly   117 AQQKALMGVAELAKGIQYEQP--IKTAWKPPRYIREMSEEEREAVRHELRILVEGETPSPPIRSF 179
            |..|.::.........:.:.|  .|..:.....|..::.::...:||:|.:.|.|..|..|..||
Human   191 APTKKIIDPLPPIDHSEIDYPPFEKNFYNEHEEITNLTPQQLIDLRHKLNLRVSGAAPPRPGSSF 255

  Fly   180 REMKFPKGILNGLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEY 244
            ....|.:.:::.:.......|||||.||:|..|:|||:||||.||||||..|:.|:::..::|: 
Human   256 AHFGFDEQLMHQIRKSEYTQPTPIQCQGVPVALSGRDMIGIAKTGSGKTAAFIWPMLIHIMDQK- 319

  Fly   245 SLPFERNEGPYGLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSEALDVISRG 309
              ..|..:||..:|:||:|||.:|.|...:.:.|..      .:||....||..:.|....:..|
Human   320 --ELEPGDGPIAVIVCPTRELCQQIHAECKRFGKAY------NLRSVAVYGGGSMWEQAKALQEG 376

  Fly   310 VHIVVATPGRLMDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATM 374
            ..|||.|||||:|.:.||...|....||..||||||.|||||..||:|.|..:..|||||||||.
Human   377 AEIVVCTPGRLIDHVKKKATNLQRVSYLVFDEADRMFDMGFEYQVRSIASHVRPDRQTLLFSATF 441

  Fly   375 PKKIQNFARSALVKPVTINVGRAGAASMNVTQQVEYVKQ-EAKVVYLLDCLQK--TAPPVLIFAE 436
            .|||:..||..|:.|:.:..|..|.|:.:|||.||.:.. .:|..:|...|.:  ::..||:|..
Human   442 RKKIEKLARDILIDPIRVVQGDIGEANEDVTQIVEILHSGPSKWNWLTRRLVEFTSSGSVLLFVT 506

  Fly   437 KKQDVDCIHEYLLLKGVEAVAIHGGKDQEERSRAVDAYRVGKKD--VLVATDVASKGLDFPNVQH 499
            ||.:.:.:...|..:|.....:||..||.||::.:..::  |||  ||||||||::|||.|:::.
Human   507 KKANAEELANNLKQEGHNLGLLHGDMDQSERNKVISDFK--KKDIPVLVATDVAARGLDIPSIKT 569

  Fly   500 VINYDMPDDIENYVHRIGRTGRSNTKGLATTLINKTTEQSVLLDLKHLLIEGKQEVPDFLDELAP 564
            |||||:..||:.:.||||||||:..||:|.||:. ..:.:...||...|....|.|...|.:||.
Human   570 VINYDVARDIDTHTHRIGRTGRAGEKGVAYTLLT-PKDSNFAGDLVRNLEGANQHVSKELLDLAM 633

  Fly   565 ET-----------EHQHLDLGDSHGCTYCGGLGHRITECPKLEAVQNKQASNIGRRDYLSNTAA 617
            :.           :.:.|::|.       ||||:|  |.|.|    ..:..:.|..:.:||..|
Human   634 QNAWFRKSRFKGGKGKKLNIGG-------GGLGYR--ERPGL----GSENMDRGNNNVMSNYEA 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
absNP_524220.1 DEADc_DDX41 188..393 CDD:350709 88/204 (43%)
SF2_C_DEAD 404..532 CDD:350174 55/132 (42%)
DDX42NP_031398.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..114 12/49 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 182..203 4/20 (20%)
Q motif 253..281 7/27 (26%)
SrmB 254..664 CDD:440279 166/430 (39%)
DEAD box 407..410 2/2 (100%)
dermokine <733..>891 CDD:455732
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 737..938
Necessary for interaction with TP53BP2. /evidence=ECO:0000269|PubMed:19377511 738..833
Blue background indicates that the domain is not in the aligned region.

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