Protein Alignment abs and DDX17

DIOPT Version :10

• Sequence 1: NP_524220.1
• Gene: abs / 40530
• FlyBaseID: FBgn0015331
• Length: 619
• Species: Drosophila melanogaster
• Sequence 2: NP_001091974.1
• Gene: DDX17 / 10521
• HGNCID: 2740
• Length: 731
• Species: Homo sapiens
• Alignment Length: 489
• Identity: 175/489 - (35%)
• Similarity: 256/489 - (52%)
• Gaps: 49/489 - (10%)

  Fly   148 IREMSEEEREAVRHELRILVEGETPSP-PIRSFREMKFPKGILNGLAAKGIKNPTPIQVQGLPTV 211
            :..::..|.:.:|.:..|.|.|....| |:.:|....||:.:::.|..:....|||||.||.|..
Human   141 VARLTPYEVDELRRKKEITVRGGDVCPKPVFAFHHANFPQYVMDVLMDQHFTEPTPIQCQGFPLA 205

  Fly   212 LAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLPFERNEGPYGLIICPSRELAKQTHEIIQHY 276
            |:|||::|||.|||||||.::||.|:....|.|   .||.:||..|::.|:||||:|..::...|
Human   206 LSGRDMVGIAQTGSGKTLAYLLPAIVHINHQPY---LERGDGPICLVLAPTRELAQQVQQVADDY 267

  Fly   277 SKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRLMDMLDKKILTLDMCRYLCMDE 341
            .|    |.  .::|....||.|....:..:.|||.|.:||||||:|.|:.....|..|.||.:||
Human   268 GK----CS--RLKSTCIYGGAPKGPQIRDLERGVEICIATPGRLIDFLESGKTNLRRCTYLVLDE 326

  Fly   342 ADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATMPKKIQNFARSALVKPVTINVGRAG-AASMNVT 405
            ||||:|||||..:|.|....:..||||::|||.||:::..|...|.....||||... :|:.|:.
Human   327 ADRMLDMGFEPQIRKIVDQIRPDRQTLMWSATWPKEVRQLAEDFLRDYTQINVGNLELSANHNIL 391

  Fly   406 QQVEYV---KQEAKVVYLL-DCLQKTAPPVLIFAEKKQDVDCIHEYLLLKGVEAVAIHGGKDQEE 466
            |.|:..   :::.|::.|: :.:.:.....:||.|.|:..|.:...:...|..|:.|||.|.|.|
Human   392 QIVDVCMESEKDHKLIQLMEEIMAEKENKTIIFVETKRRCDDLTRRMRRDGWPAMCIHGDKSQPE 456

  Fly   467 RSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHRIGRTGRSNTKGLATTL 531
            |...::.:|.||..:|:||||||:|||..:|:.|||||.|:..|:||||||||.||..||.|.|.
Human   457 RDWVLNEFRSGKAPILIATDVASRGLDVEDVKFVINYDYPNSSEDYVHRIGRTARSTNKGTAYTF 521

  Fly   532 INKTTEQSVLLDLKHLLIEGKQEVPDFLDELAPETEHQHLDLGDSHGCTYCGGLG----HRIT-- 590
            .....            ::..:|:...|:|.......:.:.|.|..|....||.|    :|.|
Human   522 FTPGN------------LKQARELIKVLEEANQAINPKLMQLVDHRGGGGGGGKGGRSRYRTTSS 574

  Fly   591 ----------ECP-KLEAVQNKQASNIGRRDYLS 613
                      ||. :|..|::.     ||||..|
Human   575 ANNPNLMYQDECDRRLRGVKDG-----GRRDSAS 603

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
abs	NP_524220.1	DEADc_DDX41	188..393	CDD:350709	86/204 (42%)
		SF2_C_DEAD	404..532	CDD:350174	53/131 (40%)
DDX17	NP_001091974.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	20..115
		DEAD-like_helicase_N	111..581	CDD:475120	166/460 (36%)
		Q motif	171..199		8/27 (30%)
		DEAD box	325..328		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	661..731
		Interaction with YAP1. /evidence=ECO:0000269|PubMed:24581491	720..728