DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment abs and ddx41

DIOPT Version :9

Sequence 1:	NP_524220.1	Gene:	abs / 40530	FlyBaseID:	FBgn0015331	Length:	619	Species:	Drosophila melanogaster
Sequence 2:	XP_012815277.1	Gene:	ddx41 / 100491281	XenbaseID:	XB-GENE-967537	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	624	Identity:	405/624 - (64%)
Similarity:	495/624 - (79%)	Gaps:	22/624 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 RSSKSSEEGDL---DNEDYVPYVPVKERKKQHMIKLGRIVQL----------VSETAQPKSSSEN 60
            |....:||.||   |:||||||||:|:|:::..:.|  .|||          |.|..|..|.|::
Frog     7 RKRVHAEEEDLELSDDEDYVPYVPLKQRRQEMSLYL--CVQLQKRMLIRRKGVLEEEQKDSGSDH 69

  Fly    61 ENEDDSQGAHDVETWGRKYNISLLDQHTELKKIAEAKKLSAVEKQLREEEKIMESIAQQKALMGV 125
            ..::|     |:.. |.:.|:||||||..||:.|||:|.||.||||:|||||:||:.:.:|||.|
Frog    70 RGDED-----DIPL-GPRSNVSLLDQHQHLKEKAEARKESAKEKQLKEEEKILESVTEGRALMSV 128

  Fly   126 AELAKGIQYEQPIKTAWKPPRYIREMSEEEREAVRHELRILVEGETPSPPIRSFREMKFPKGILN 190
            .|:||||.|:.||||:|||||:|.||||...:.||.:..||||||....||:||:|||||..||.
Frog   129 KEMAKGITYDDPIKTSWKPPRHILEMSEARHDRVRSKYHILVEGERIPQPIKSFKEMKFPAAILR 193

  Fly   191 GLAAKGIKNPTPIQVQGLPTVLAGRDLIGIAFTGSGKTLVFVLPVIMFALEQEYSLPFERNEGPY 255
            ||..|||.:|||||:||:||:|:|||:||||||||||||||.||||||.||||..|||.:.||||
Frog   194 GLKKKGIHHPTPIQIQGIPTILSGRDMIGIAFTGSGKTLVFTLPVIMFCLEQEKRLPFAKREGPY 258

  Fly   256 GLIICPSRELAKQTHEIIQHYSKHLQACGMPEIRSCLAMGGLPVSEALDVISRGVHIVVATPGRL 320
            |||||||||||:|||.||::|...||....|.:|:.|.:||:.|.|.::.|.:|||::|||||||
Frog   259 GLIICPSRELARQTHSIIEYYCHLLQEDNFPHLRTALCIGGMSVKEQMETIKQGVHMMVATPGRL 323

  Fly   321 MDMLDKKILTLDMCRYLCMDEADRMIDMGFEEDVRTIFSFFKGQRQTLLFSATMPKKIQNFARSA 385
            ||:|.||:::||:||||.:||||||||||||||:|||||:||||||||||||||||||||||:||
Frog   324 MDLLQKKMVSLDICRYLALDEADRMIDMGFEEDIRTIFSYFKGQRQTLLFSATMPKKIQNFAKSA 388

  Fly   386 LVKPVTINVGRAGAASMNVTQQVEYVKQEAKVVYLLDCLQKTAPPVLIFAEKKQDVDCIHEYLLL 450
            ||||:|||||||||||::|.|:|||||:|||:||||:|||||.||||||||||.|||.|||||||
Frog   389 LVKPITINVGRAGAASLDVIQEVEYVKEEAKMVYLLECLQKTPPPVLIFAEKKADVDAIHEYLLL 453

  Fly   451 KGVEAVAIHGGKDQEERSRAVDAYRVGKKDVLVATDVASKGLDFPNVQHVINYDMPDDIENYVHR 515
            |||||||||||||||||::|::|:|..||||||||||||||||||.:|||:|||||::|||||||
Frog   454 KGVEAVAIHGGKDQEERTKAIEAFREEKKDVLVATDVASKGLDFPAIQHVVNYDMPEEIENYVHR 518

  Fly   516 IGRTGRSNTKGLATTLINKTTEQSVLLDLKHLLIEGKQEVPDFLDELAPETEHQHLDLGDSHGCT 580
            |||||||...|:|||.|||:.::|||:|||.||:|.||.||..|..|....|.. ||:||..||.
Frog   519 IGRTGRSGNTGIATTFINKSCDESVLMDLKALLMEAKQRVPPVLQVLNGSDETM-LDIGDERGCA 582

  Fly   581 YCGGLGHRITECPKLEAVQNKQASNIGRRDYLSNTAADY 619
            :|||||||||:||||||:|.||.|.:||:|||:.::.|:
Frog   583 FCGGLGHRITDCPKLEAMQTKQVSTMGRKDYLATSSMDF 621

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
abs	NP_524220.1	DEADc	179..393	CDD:238167	153/213 (72%)
		DEXDc	192..397	CDD:214692	148/204 (73%)
		Helicase_C	414..523	CDD:278689	91/108 (84%)
ddx41	XP_012815277.1	DEADc	182..396	CDD:238167	153/213 (72%)
		DEXDc	195..408	CDD:214692	154/212 (73%)
		Helicase_C	417..526	CDD:278689	91/108 (84%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	276	1.000	Domainoid score	I1706
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H9431
Inparanoid	1	1.050	803	1.000	Inparanoid score	I488
OMA	1	1.010	-	-		QHG53695
OrthoDB	1	1.010	-	-		D183201at33208
OrthoFinder	1	1.000	-	-		FOG0005487
OrthoInspector	1	1.000	-	-		oto104974
Panther	1	1.100	-	-	LDO	PTHR47958
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4314
SonicParanoid	1	1.000	-	-		X3903
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	13.110