DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LTBP2 and mua-3

DIOPT Version :9

Sequence 1:NP_000419.1 Gene:LTBP2 / 4053 HGNCID:6715 Length:1821 Species:Homo sapiens
Sequence 2:NP_001022674.1 Gene:mua-3 / 176430 WormBaseID:WBGene00003482 Length:3767 Species:Caenorhabditis elegans


Alignment Length:2336 Identity:477/2336 - (20%)
Similarity:701/2336 - (30%) Gaps:879/2336 - (37%)


- Green bases have known domain annotations that are detailed below.


Human    87 RAQPGWG-SPRRPTEAEARRPSRAQQSRRVQPPAQTR-RSTPLGQQQPAPRTRAAPALPRLGTPQ 149
            :.:.||. :...|..:..|...:|.....:...|:.. |.||:|     |..:..          
 Worm   692 KCRSGWSDTSLDPLRSPGRSCKKADMCSNIDCAAEAECRETPIG-----PMCQCV---------- 741

Human   150 RSGAAPPTPPRGRLTGRNVCGGQCCPGWTTANSTNHCIKPVCEPPCQNRGSCSRPQLCV-CRSGF 213
             ||....:...||..|| ||..          ..|.|        .:.|..||....|: ...||
 Worm   742 -SGYVDVSRQHGRPAGR-VCRA----------VVNEC--------AEGRHDCSSHATCIDTADGF 786

Human   214 RGARCEEVIPDEEFDPQNSRLAPRRWAERSPNLRRSSAAGEGTLARAQPPAPQSPPAPQSPPAGT 278
            . .||::...||..|                .|:.   .|:..:...||          .||...
 Worm   787 T-CRCKDSYRDESSD----------------TLKH---PGKNCVRTVQP----------DPPECD 821

Human   279 LSGLSQTHPSQQHV--------------GLS-----RTVRLHPTA-----TASSQLSSNALPPGP 319
            :|......|:::.|              |.|     |.|.::..|     |.........|..|.
 Worm   822 VSDPMSCDPAKREVCIFVENTYKCRCANGYSRLPDGRCVVINECAEPRLNTCGKNAECIDLAEGY 886

Human   320 GLEQRDGTQQAVPLEHPSSPWGLNLTEKIKKIKIVFTPTICKQTCARGHCANSCERGDTTTLYSQ 384
            ..:.|.|.....|:..|.......:.|...|.|.            ...|:.:....||...|| 
 Worm   887 TCQCRSGYADISPVSQPGRICRARVNECSNKEKY------------NVDCSENAICADTEHSYS- 938

Human   385 GGHGHDPKSGFRIYFCQIPCLNGGRCI-GRDECWCPA-NSTGK--FC------HLPIPQP---DR 436
                ...:.||.........|.|.||| ..:||..|: |...|  ||      ::...:|   |.
 Worm   939 ----CRCRPGFADVSAAFNKLPGRRCIEAVNECASPSLNDCSKNAFCEDAKEGYICTCRPGYVDN 999

Human   437 EP-----PGR-GSRPRALLEAPLKQSTFTL-----PLSNQLASVNPSLVKVHIHHPPE------- 483
            .|     ||| .::|...::..||.::|:.     | .|.....|.:.|:.|..|..|       
 Worm  1000 SPNAARHPGRICTKPVEKIKTDLKDTSFSTDDGCDP-KNPKCGANEACVQRHGQHNCECVETAFR 1063

Human   484 ---ASVQIHQVAQVRGGVEE-ALVENSVETRP----PPWLPASPGHSLWDSNNIPAR-------- 532
               .|.:::.....|...:: |:..|..::..    |.::..|.     |..|.|.|        
 Worm  1064 YTDGSCRVYSACSKRNTCDKNAICLNRFDSYTCQCRPGYIDLSA-----DLTNAPGRICKELINE 1123

Human   533 SGEPPRPLPPAAPRPRGLLGRCYLNTVNG---QCANPLLELTTQEDCCGSVGAFWGVTLCAPCPP 594
            .........|.|        || ::..||   ||.:..::::::.:                   
 Worm  1124 CASSDNECSPYA--------RC-IDATNGYACQCLDGFIDVSSRYN------------------- 1160

Human   595 RPASPVIENGQLECPQGYKRLNLTHCQDINECLTLGLCKDAECVNTRGSYLCTCRPGLMLDPSRS 659
            :|......|...||.:          :.:|.|     .::|:||:|...|.|.|..|.:      
 Worm  1161 KPPGRQCTNSNNECSE----------KSLNTC-----DENADCVDTPDGYTCQCYGGFV------ 1204

Human   660 RCVSDKAISMLQGLCYRSLGPG-TCTLPLAQRITKQICCCSRVGKAWGSECEKCPLPGTEAFREI 723
             .||..|          :|.|| .||:...                       ||...|:....|
 Worm  1205 -DVSSNA----------NLPPGRVCTVQTT-----------------------CPKQKTDLVFLI 1235

Human   724 CPAGH--GYTYASSDIRLSMRKAEEEELARPPR------------------EQGQRSSGALPGPA 768
            ..:|.  .|.:.:..:|......|..|:.|...                  :.|.|.| .|.|.:
 Worm  1236 DGSGSIGSYVFKNEVLRFVREFVELFEIGRSKTRVGLIQYSDQIRHEFDLDQYGDRDS-LLKGIS 1299

Human   769 ERQPLRVVTDTWL------------EAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTP------ 815
            |.|.|..:|.|..            ..|..|.:.|.....:..:...:...|||.|.:.      
 Worm  1300 ETQYLTGLTRTGAAIQHMVQEGFSERRGARPQQSDIARVAIILTDGRSQDNVTGPADSARKLSIN 1364

Human   816 ---------------------------------------PMPEQGIAEIQEEQVTPSTDVLVTLS 841
                                                   .|.::.......:|.|||.||....:
 Worm  1365 TFAIGVTDHVLASELESIAGSPNRWFYVDKFKDLDTRLRSMIQKAACPSPTKQETPSEDVCNPRT 1429

Human   842 TPGIDR----------------CAAG-----ATNVCG--------------PGTCVNLP-DGYRC 870
            ..|.||                |..|     .|.|||              |..|...| ..:||
 Worm  1430 QTGCDRSLNEHCAVENGRPRCVCPEGFTRHPFTRVCGGDLCNPQLITSCIFPEECQITPYKNFRC 1494

Human   871 VCSPGYQLHPSQAYCTDDNECLRDP------------CKGKGRCINRVGSYSCFCYPGYTLATSG 923
            .|..||.......:|....|....|            |....||.|....:.|.|.||:....:|
 Worm  1495 SCPEGYNRDYRSGFCVSVKEVQISPQHDANCHNGGVRCSENERCTNDGSDWFCECLPGFERIRNG 1559

Human   924 ATQECQDINECEQPGVCSGG-----------QCTNTEGSYHCECDQGYIMVRKGHCQDINECRHP 977
                     :|..||.|:..           ||......|.|:|.:             ||.|||
 Worm  1560 ---------QCAYPGSCNPNDPMSCDVRKRQQCLPRGNIYTCQCGR-------------NEKRHP 1602

Human   978 GT-------CPDG--------RCVNSPGSYTCLACEEGYRGQSGS--------CVDV-NECLT-- 1016
            .|       |..|        ||:::..||.| ||:.|:...|.:        ||.: ||||.  
 Worm  1603 ITDICLKNECLTGEHDCDRSARCIDTDESYIC-ACQSGFIDHSPNPSERPGRVCVALQNECLDGS 1666

Human  1017 ----------------------------------PG-VCAH--GKCTN---------------LE 1029
                                              || ||..  .:|||               :|
 Worm  1667 NRCSPNALCTDTEEGYVCRCKSGFVDYSPNPQTFPGMVCKELVNECTNPRLNQCDRNAHCIDTIE 1731

Human  1030 GSFRCSCEQGYEVTSDEKG-----CQDV---DECAS-------------------RASCPTG--- 1064
            | :.|.|:.|: |..||.|     |:.:   |:|:.                   ..:||.|   
 Worm  1732 G-YSCICKPGF-VDMDEFGNPGRRCEQIKTNDKCSPGKNDCDRNARCIQIGDDDYSCACPPGFKD 1794

Human  1065 ---------------------------------LCLNTEGSFACSACENGYW------VNEDGTA 1090
                                             :|.:|:..:.| .|..|:.      ..:.|..
 Worm  1795 KSPSSSRPGRLCIPVIPECDNPTLNDCDSPDRAVCTDTDDGYMC-RCRQGFLDISPSISVKPGRL 1858

Human  1091 CEDL--------DECAFPGVCPSGVCTNTAGSFSCKDCDGGY---------RPSPLGDSCED-VD 1137
            |:.|        |:||..|    |:|.:...||:|: |...|         ||   |..|:. ::
 Worm  1859 CKPLQNECALGIDDCARDG----GICEDNPDSFTCR-CAMNYLDVSFDRVTRP---GRKCKRLIN 1915

Human  1138 ECEDPQSSCL-GGECKNTVGSYQCLCPQG-FQLANGTVCED-------VNECMGEEH-CAPHGEC 1192
            ||:..|:.|. ...|.:|..||.|.|||. ..|:..||...       :|||....| |:|:.:|
 Worm  1916 ECQTGQNDCSEEATCTDTEDSYICACPQSHIDLSPDTVNRPGRRCLMRINECTSNRHDCSPNADC 1980

Human  1193 LNSHGSFFCLCAPGFV------SAEGGTSCQD--VDECAT--TDPCVGGHCVNTEGSFNCLCETG 1247
            :::..|:.|.|...||      |...|..|:.  ||||.|  .|..|...|.:....:.|.|...
 Worm  1981 IDTPESYKCRCRDDFVDESPDSSRRPGRICRPALVDECRTGKHDCHVNAICQDLPQGYTCQCSAD 2045

Human  1248 F-----------------QPSPESGECVDID---ECEDYGDPVC----GTWKCENSPGSYRCVLG 1288
            |                 :|:|...|| .:|   :|:.:.:.||    |..||           .
 Worm  2046 FVDVSPHRASHPGRLCQPRPTPPPPEC-RLDGGNQCKVHLNEVCRLMGGEPKC-----------S 2098

Human  1289 CQPGFHMAPNGDCIDIDEC----ANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDCVD---- 1345
            |...:....:|.|..|:||    .||  |.:...|.:....:.|.|..||:      |..|    
 Worm  2099 CPVNYQRDSSGSCSIINECLFTQLND--CHTAADCIDQVQGYTCQCRDGFK------DIGDRRRP 2155

Human  1346 -------VNECEL-MLAVCGA-ALCENVEGSFLCLCASDLEEYDAQEGHCRPRGAGGQSMSEA-- 1399
                   ||||:. .|..|.. |.|.::|..:.|.|.....::    .|.||.....|..:|.  
 Worm  2156 GRMCKPMVNECQYPHLNDCHQNAACIDLEEGYECKCNQGFMDH----SHGRPGRICKQLTNECLR 2216

Human  1400 PTGDHAPAPTRMDCYSGQKGH-----------APCSSVLGRNTTQA--ECC------CTQGASWG 1445
            |:.:......|  |...::|:           :|..::.||...:.  ||.      |.:.|...
 Worm  2217 PSLNSCDRNAR--CIDKEEGYECECRDGFIDVSPSPTLKGRACRELVNECANSRLNDCDKNARCK 2279

Human  1446 DA-----CDLCP--SEDSAE-----------FSEICPSGKGYIPVEGAWTFGQTMYTDADECVIF 1492
            |.     || ||  |:|.:.           |...|.||.............:..:|    |.  
 Worm  2280 DTMDSYECD-CPVNSKDISPSPSFPGRVCLMFINECESGVHDCDPSATCRDNEQSFT----CE-- 2337

Human  1493 GPGLCPNG---RCLN--TVPGYVCL-----CNPGFHYDASHKKCEDHD-----ECQD-------- 1534
                ||:|   |..|  ..||.||:     |..|.|..:||..|.|.:     ||:|        
 Worm  2338 ----CPSGFVDRSPNKHARPGRVCVKLVDECREGRHTCSSHADCRDLEEGYTCECRDGYVDRSPN 2398

Human  1535 LACENGECV--------NTEGSFHCFCSPPLTLDLSQQRCMNSTSSTEDLPD------------- 1578
            ||.:.|...        |.:.|....|.|   |...:.:|:......:..|.             
 Worm  2399 LASQPGRVCSAPEVCPPNHDCSSAAVCEP---LGGMKYQCVCIQGYVDQSPGSQKGRVCVRNNAC 2460

Human  1579 HDIHMDICWKKVTNDVCSEPLRGHRTTYTECCCQDG-----EAWSQQCALCPP------------ 1626
            ||..::.|.:   |.:|.:..||:|     |.|:.|     ...||:..:|.|            
 Worm  2461 HDPRLNTCSR---NAICYDEPRGYR-----CECKRGFMDRSPDSSQRGRVCEPPPPPSPPPRHPC 2517

Human  1627 --------------RSSEVYAQLCNVARIEAEREAGVHFRPG--------YEYGPGPDDLHYS-- 1667
                          |::...:..|......|:|......:||        ....|..:|.|.:  
 Worm  2518 QDPERNDCHPAGTCRATGAQSYTCECLSGYADRSPDPRNKPGRLCVLTEPVCLDPEQNDCHAAAI 2582

Human  1668 ---IYGPDGAPFYNYLGPEDTVPEPA------------------------------FPNTAGHSA 1699
               :.||:........|..|..|:|.                              .||  |::.
 Worm  2583 CSEVNGPEKYTCKCRDGYTDESPDPLRRPGRICKGLINECLDRSLNDCHSLAVCKDLPN--GYTC 2645

Human  1700 DRTPILESPLQPSELQPHYVASHPEPPAGFEGLQAEECG--ILNGCEN-GRCVRVREGYTCDCFE 1761
                  :.|:...:..|     .|..|.....|...||.  .||.|.. ..|.....||.|.|..
 Worm  2646 ------QCPINAKDQSP-----DPRKPGRICSLSVNECANPSLNSCSAFADCFDEENGYRCRCRN 2699

Human  1762 GFQLD----AAHMACVDVNECD--DLNGPAVLC-VHGYCENTEGSYRCHCSPGYVAEAGPP 1815
            |:..|    ..|.....:||||  :||.    | .:..|.:|.|.|.|.|...| .:.|||
 Worm  2700 GYHDDDPAHPGHRCSFMINECDSSNLND----CDRNANCIDTAGGYDCACKAPY-RDEGPP 2755

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LTBP2NP_000419.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..58
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..165 15/79 (19%)
Heparin-binding 94..115 3/20 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..339 21/133 (16%)
Heparin-binding 232..249 1/16 (6%)
Heparin-binding 344..354 3/9 (33%)
Cell attachment site. /evidence=ECO:0000255 375..377 0/1 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544 7/45 (16%)
EGF_CA 622..>651 CDD:214542 9/28 (32%)
TB 683..719 CDD:279073 5/35 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..772 9/45 (20%)
EGF_CA 887..918 CDD:214542 10/42 (24%)
EGF_CA 930..>960 CDD:214542 9/40 (23%)
EGF_CA 970..1005 CDD:238011 16/49 (33%)
EGF_CA 1010..1041 CDD:214542 16/85 (19%)
EGF_CA 1051..1091 CDD:284955 11/103 (11%)
EGF_CA 1093..1133 CDD:284955 15/56 (27%)
EGF_CA 1135..1175 CDD:214542 15/42 (36%)
EGF_CA 1176..1217 CDD:214542 14/54 (26%)
EGF_CA 1218..1257 CDD:284955 13/59 (22%)
EGF_CA 1303..1335 CDD:238011 10/35 (29%)
TB 1423..1458 CDD:279073 13/49 (27%)
EGF_CA 1485..1518 CDD:214542 12/42 (29%)
TB 1595..1630 CDD:279073 12/65 (18%)
C-terminal domain. /evidence=ECO:0000269|PubMed:17293099 1639..1821 51/230 (22%)
EGF_CA 1774..>1808 CDD:214542 13/36 (36%)
mua-3NP_001022674.1 LDLa 32..60 CDD:238060
LDLa 131..164 CDD:238060
EGF_3 766..795 CDD:289699 9/37 (24%)
vWA_collagen_alphaI-XII-like 1229..1398 CDD:238759 25/169 (15%)
EGF_3 1662..1691 CDD:289699 2/28 (7%)
EGF_CA 1709..1755 CDD:214542 12/47 (26%)
EGF_CA 1964..1997 CDD:214542 11/32 (34%)
SEA 2873..2998 CDD:214554
SEA 3049..3173 CDD:214554
EGF_CA 3328..3364 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D4721at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.920

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