DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LTBP2 and notch1

DIOPT Version :9

Sequence 1:NP_000419.1 Gene:LTBP2 / 4053 HGNCID:6715 Length:1821 Species:Homo sapiens
Sequence 2:NP_001090757.1 Gene:notch1 / 100037842 XenbaseID:XB-GENE-479318 Length:2522 Species:Xenopus tropicalis


Alignment Length:1635 Identity:392/1635 - (23%)
Similarity:562/1635 - (34%) Gaps:629/1635 - (38%)


- Green bases have known domain annotations that are detailed below.


Human   404 CLNGGRCI----GRDECWCPANSTGKFCHLPIPQPDREPPGRGSRPRALLEAPLKQSTFTLPLSN 464
            |||||||.    |...|.|.::..|:.|..|.|                           ..|.|
 Frog    29 CLNGGRCEMTPGGTGVCLCSSSYFGERCQYPNP---------------------------CALKN 66

Human   465 QLASVNPSLVKVHIHHPPEASVQIHQVAQVRGGVEEALVENSVETRPPPWLPASPGHSLWDSNNI 529
            |..:.                          |..|..|:.|:::.                    
 Frog    67 QCMNF--------------------------GTCEPVLLGNAIDF-------------------- 85

Human   530 PARSGEPPRPLPPAAPRPRGLLGRCYLNTVNGQCAN---------PLLELTTQEDCCGSVGAFWG 585
                         ....|.|...:..|..|:..|.|         .||...:...|....|  |.
 Frog    86 -------------TCHCPVGFTDKVCLTPVDNACVNNPCRNGGTCELLSSVSDYRCRCPPG--WT 135

Human   586 VTLCAPCPPRPASPVIENGQ---------LECPQGYKRLNLTHCQDINECLTLGLCKD-AECVNT 640
            ...|....|..::|....|:         .:||.|:.  ..|..|||||| :...|:: .:|:|.
 Frog   136 GDSCQQADPCASNPCANGGKCLPFETQYICKCPSGFH--GATCKQDINEC-SQNPCRNGGQCLNE 197

Human   641 RGSYLCTCRPGLMLDPSRSRCVSDKAISMLQGLCYRSLGPGTCTLPLAQRITKQICCCSRVGKAW 705
            .|||.|.|:                                       .|.|             
 Frog   198 FGSYRCNCQ---------------------------------------NRFT------------- 210

Human   706 GSECEKCPLPGTEAFREICPAGHGYTYASSDIRLSMRKAEEEELARPPREQGQRSSGALPGPAER 770
            |..||:..:|...:     |..:|.|...:|                                  
 Frog   211 GRNCEEPYVPCNPS-----PCLNGGTCRQTD---------------------------------- 236

Human   771 QPLRVVTDTWLEAGTIPDKGDSQAGQVTTSVTHAPAWVTGNATTPPMPEQGIAEIQEEQVTPSTD 835
                   ||..|...:|    ..:||              |.              ||       
 Frog   237 -------DTSYECTCLP----GFSGQ--------------NC--------------EE------- 255

Human   836 VLVTLSTPGIDRCAAGATNVCGPGTCVNLPDGYRCVCSPGYQLHPSQAYCTDD-NEC--LRDPCK 897
                    .||.|.  :.|....||||:..:.|.|.|.|.:    :..|||:| :||  :.:.|:
 Frog   256 --------NIDDCP--SNNCRNGGTCVDGVNTYNCQCPPDW----TGQYCTEDVDECQLMPNACQ 306

Human   898 GKGRCINRVGSYSCFCYPGYTLATSGATQEC-QDINECEQPGVCSGGQCTNTEGSYHCECDQGYI 961
            ..|.|.|..|.|:|.|..|:|      .::| ::|::|......||..|.:...|:.|||..|  
 Frog   307 NGGTCHNTYGGYNCVCVNGWT------GEDCSENIDDCANAACHSGATCHDRVASFFCECPHG-- 363

Human   962 MVRKG-HCQDINEC-RHPGTCPDG-RCVNSP--GSYTCLACEEGYRGQSGSC-VDVNEC-LTPGV 1019
              |.| .|...|.| .:|  |.:| .|..:|  |...| .|..||.|.  :| .||:|| |....
 Frog   364 --RTGLLCHLDNACISNP--CNEGSNCDTNPVNGKAIC-TCPPGYTGP--ACNNDVDECSLGANP 421

Human  1020 CAH-GKCTNLEGSFRCSCEQGYEVTSDEKGCQ-DVDECASRASCPTGLCLNTEGSFACSACENGY 1082
            |.| |:|||..|||:|:|.|||.    ...|: ||:||.|........||:..|.|.| .|..||
 Frog   422 CEHGGRCTNTLGSFQCNCPQGYA----GPRCEIDVNECLSNPCQNDATCLDQIGEFQC-ICMPGY 481

Human  1083 WVNEDGTACE-DLDECA----------------FPGVCPSGV----------------CTNTA-- 1112
                :|..|| ::||||                |...||:|.                |.|.|  
 Frog   482 ----EGLYCETNIDECASNPCLHNGKCVDKINEFHCECPTGFNGNLCQHHVDECASTPCKNGAKC 542

Human  1113 ----GSFSCKDCDGGYRPSPLGDSCE-DVDEC-EDPQSSCLGGECKNTVGSYQCLCPQGFQLANG 1171
                .|::|: |..|:    .|..|| |::|| .||   |..|.||:.:.::.|||..|:   .|
 Frog   543 LDGPNSYTCQ-CTEGF----TGRHCEQDINECIPDP---CHYGTCKDGIATFTCLCRPGY---TG 596

Human  1172 TVCE-DVNECMGEEHCAPHGECLNSHGSFFCLCAPGFVSAEGGTSCQ-DVDECATTDPCVGGHCV 1234
            .:|: |:|||:.:. |...|:|.:....:.|.|..|..    |.:|: ::|:|| ::||..|.|:
 Frog   597 RLCDNDINECLSQP-CQNGGQCTDRENGYICTCPKGTT----GVNCETNLDDCA-SNPCDYGKCI 655

Human  1235 NTEGSFNCLCETGFQPSPESGE-C-VDIDECEDYGDPVCGTWKCENSPGSYRCVLGCQPGFHMAP 1297
            :....:.|.||.|:     :|: | ::||||.  .:|......|::....:.||  |..|:|   
 Frog   656 DKIDGYECTCEPGY-----TGKMCNINIDECA--SNPCRNGGTCKDKINGFTCV--CPDGYH--- 708

Human  1298 NGDCI-DIDECANDTMCGSHGFCDNTDGSFRCLCDQGFEISPSGWDC-VDVNECELMLAVCGAAL 1360
            :..|: :::|| |...| .||.|.:....::|.||.|:    ||.:| |:.||||....:.|.. 
 Frog   709 DHMCLSEVNEC-NSNPC-IHGTCHDGINGYKCDCDAGW----SGSNCDVNNNECESNPCMNGGT- 766

Human  1361 CENVEGSFLCLCASDLEEYDAQ-------EGHCRPRGAGGQSMSEAPTGDHAPAPTRMDCYSGQK 1418
            |:::.|:::|.|.:.....:.|       ...|..||                  |.:|..:|.|
 Frog   767 CKDMTGAYICTCRAGFSGPNCQTNINECASNPCLNRG------------------TCIDDVAGYK 813

Human  1419 GH-------APCSSVLGRNTTQAECC---CTQGASWGDACDLCPSEDSAEFSEICPSGKGYIPVE 1473
            .:       |.|.:||      |.|.   |..|....:      |||...||..||.|       
 Frog   814 CNCMLPYTGAICEAVL------APCSGSPCKNGGRCKE------SEDYETFSCECPPG------- 859

Human  1474 GAWTFGQTMYTDADECVIFGPGLCPNG-RCLNTVPGYVCLCNPGF---HYDASHKKC-------- 1526
              |. |||...|.:|||   ...|.|| .|.||...|.|.|.||:   |.:.....|        
 Frog   860 --WQ-GQTCEIDMNECV---NRPCRNGAMCQNTNGSYKCNCKPGYAGRHCETDIDDCQPNPCHNG 918

Human  1527 ------------------------EDHDECQDLACENG----ECVNTEGSFHCFCSPPL------ 1557
                                    ||.:||....|:||    :|||   |:.|.|.|..      
 Frog   919 GSCSDGINMFFCNCPAGFRGPKCEEDINECASNPCKNGANCTDCVN---SYTCTCQPGFSGIHCE 980

Human  1558 --TLDLSQQRCMN--------STSS-------TEDLPDHDIHMDICWKK--VTNDVCSEPLRGHR 1603
              |.|.::..|.|        :|.|       |.|...|||:.  |..|  :....|.:....::
 Frog   981 NNTPDCTESSCFNGGTCIDGINTFSCQCPPGFTGDYCQHDINE--CDSKPCLNGGTCQDSYGAYK 1043

Human  1604 TT----YTECCCQD-------------GEAWS----QQCALCPPRSSEVYAQLCNVARIEAEREA 1647
            .|    ||...||:             |:.|.    .:|. |....:.||..:.:|:...|.::.
 Frog  1044 CTCPQGYTGLNCQNLVRWCDSSPCKNGGKCWQTNNFYRCE-CKSGWTGVYCDVPSVSCEVAAKQQ 1107

Human  1648 GV------------------HF---RPGY----------EYGPGPDDLHYSIYGPDGAPFYNYLG 1681
            ||                  ||   :.||          |..|.|..        :||...:|||
 Frog  1108 GVDIAHLCRNSGMCVDTGNTHFCRCQAGYTGSYCEEQVDECSPNPCQ--------NGATCTDYLG 1164

Human  1682 PEDTVPEPAFPNTAGHSADRTPILESPLQPSELQPHYVASHPEPPAGFEGL----QAEECGILNG 1742
                          |:|.                        |..||:.|:    :..|| :.:.
 Frog  1165 --------------GYSC------------------------ECVAGYHGVNCSEEINEC-LSHP 1190

Human  1743 CEN-GRCVRVREGYTCDCFEGFQLDAAHMAC-VDVNECDDLNGPAVL---CV-HGYCENTEGSYR 1801
            |.| |.|:.:...|.|.|..|.|  ..|  | ::|::|........|   |. :|.|.:..|.|.
 Frog  1191 CHNGGTCIDLINTYKCSCPRGTQ--GVH--CEINVDDCTPFYDSVSLEPKCFNNGKCIDRVGGYN 1251

Human  1802 CHCSPGYVAE 1811
            |.|.||:|.|
 Frog  1252 CICPPGFVGE 1261

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LTBP2NP_000419.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 38..58
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 81..165
Heparin-binding 94..115
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 229..339
Heparin-binding 232..249
Heparin-binding 344..354
Cell attachment site. /evidence=ECO:0000255 375..377
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 510..544 0/33 (0%)
EGF_CA 622..>651 CDD:214542 13/29 (45%)
TB 683..719 CDD:279073 6/35 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 744..772 0/27 (0%)
EGF_CA 887..918 CDD:214542 12/33 (36%)
EGF_CA 930..>960 CDD:214542 9/29 (31%)
EGF_CA 970..1005 CDD:238011 13/38 (34%)
EGF_CA 1010..1041 CDD:214542 18/32 (56%)
EGF_CA 1051..1091 CDD:284955 14/39 (36%)
EGF_CA 1093..1133 CDD:284955 16/77 (21%)
EGF_CA 1135..1175 CDD:214542 14/40 (35%)
EGF_CA 1176..1217 CDD:214542 11/40 (28%)
EGF_CA 1218..1257 CDD:284955 12/39 (31%)
EGF_CA 1303..1335 CDD:238011 11/31 (35%)
TB 1423..1458 CDD:279073 10/37 (27%)
EGF_CA 1485..1518 CDD:214542 15/36 (42%)
TB 1595..1630 CDD:279073 10/55 (18%)
C-terminal domain. /evidence=ECO:0000269|PubMed:17293099 1639..1821 48/214 (22%)
EGF_CA 1774..>1808 CDD:214542 11/37 (30%)
notch1NP_001090757.1 EGF_CA 108..140 CDD:238011 6/33 (18%)
EGF 145..175 CDD:278437 5/31 (16%)
EGF_CA 179..215 CDD:238011 16/88 (18%)
EGF_CA 223..254 CDD:238011 11/108 (10%)
EGF_CA 256..292 CDD:238011 13/41 (32%)
EGF_CA 294..331 CDD:238011 13/42 (31%)
EGF_CA 334..369 CDD:238011 12/38 (32%)
EGF_CA 411..449 CDD:238011 19/41 (46%)
EGF_CA 451..487 CDD:238011 14/40 (35%)
EGF_CA 489..525 CDD:238011 8/35 (23%)
EGF_CA 528..563 CDD:238011 8/39 (21%)
EGF_CA 565..599 CDD:238011 14/39 (36%)
EGF_CA 602..638 CDD:238011 11/40 (28%)
EGF_CA 640..674 CDD:238011 12/39 (31%)
EGF_CA 677..712 CDD:238011 11/41 (27%)
EGF_CA 716..749 CDD:238011 13/38 (34%)
EGF_CA 754..788 CDD:238011 9/34 (26%)
EGF_CA 790..826 CDD:238011 8/53 (15%)
EGF_CA 833..866 CDD:238011 14/48 (29%)
Plasmod_Pvs28 837..1005 CDD:283826 50/189 (26%)
EGF_CA 868..904 CDD:238011 16/38 (42%)
EGF_CA 906..942 CDD:238011 1/35 (3%)
EGF_CA 944..980 CDD:238011 13/38 (34%)
EGF_CA 987..1018 CDD:238011 6/30 (20%)
EGF_CA 1020..1056 CDD:238011 8/37 (22%)
EGF_CA 1145..1179 CDD:238011 14/79 (18%)
EGF_CA 1183..1218 CDD:238011 12/39 (31%)
EGF_CA <1237..1264 CDD:238011 11/25 (44%)
EGF_CA 1266..1303 CDD:238011
EGF_CA <1314..1345 CDD:238011
NL 1440..1477 CDD:197463
LNR 1 1447..1487
Notch 1485..1520 CDD:278494
LNR 2 1488..1529
Notch 1525..1560 CDD:278494
LNR 3 1530..1564
NOD 1564..1615 CDD:284282
NODP 1666..1728 CDD:284987
ANKYR <1870..1980 CDD:223738
ANK <1870..1979 CDD:238125
ANK repeat 1877..1923 CDD:293786
ANK 1 1877..1920
ANK repeat 1925..1956 CDD:293786
ANK 2 1925..1954
Ank_5 1945..2000 CDD:290568
ANK 1953..2079 CDD:238125
ANK repeat 1958..1990 CDD:293786
ANK 3 1958..1988
ANK repeat 1992..2023 CDD:293786
ANK 4 1992..2021
Ank_2 1997..2089 CDD:289560
ANK repeat 2025..2089 CDD:293786
ANK 5 2025..2054
ANK 6 2058..2087
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2146..2229
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2365..2404
DUF3454 2446..2507 CDD:288764
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 2449..2522
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
NCBI 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.910

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