DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14641 and RBM22

DIOPT Version :9

Sequence 1:	NP_649440.3	Gene:	CG14641 / 40529	FlyBaseID:	FBgn0037220	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_060517.1	Gene:	RBM22 / 55696	HGNCID:	25503	Length:	420	Species:	Homo sapiens

Alignment Length:	435	Identity:	250/435 - (57%)
Similarity:	312/435 - (71%)	Gaps:	43/435 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSMSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRF 65
            |:.|..:|||||||||||:||||||||||:|||:||.||::|||||||.||||:||||||.||||
Human     1 MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRF 65

  Fly    66 KKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDG 130
            ||||:||||::|||||||||||||||||||||||.|...|:||:||||||||.||::.::.:.||
Human    66 KKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDG 130

  Fly   131 TEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCE 195
            |...|.:|::.:.::||.|||||.|||||||||||||||||||||||||||||:||.:|||||.:
Human   131 TRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLAD 195

  Fly   196 QNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRS 260
            |||||||||.|||||:|::|||:::|.|:||||:.|||||||.|.:.|||.:||:.||||||||:
Human   196 QNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRT 260

  Fly   261 IALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLAGI- 324
            |.:|.||||||:|:..|.|||:|||::||||::.||::::||..|||.:|...:.|...| :||
Human   261 ITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTD-SGIK 324

  Fly   325 ------------PPPSAKPN---DYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAA 374
                        |||:|:..   :||||       .|:|           |.:...:...|
Human   325 LEPVPGLPGALPPPPAAEEEASANYFNL-------PPSG-----------PPAVVNIALPP---- 367

  Fly   375 PYGNATSTALSSSGVNLDSISIPPP----PGQVPYPSQDASRMGA 415
            |.|.|..............:..|||    ||.:.|||||..||||
Human   368 PPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGA 412

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14641	NP_649440.3	ZnF_C3H1	159..185	CDD:214632	25/25 (100%)
		RRM	186..>309	CDD:223796	78/122 (64%)
		RRM_RBM22	231..304	CDD:240670	45/72 (63%)
RBM22	NP_060517.1	ZnF_C3H1	159..185	CDD:214632	25/25 (100%)
		RRM_RBM22	231..304	CDD:409671	45/72 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	303..343		12/40 (30%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..420		15/41 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143575
Domainoid	1	1.000	399	1.000	Domainoid score	I740
eggNOG	1	0.900	-	-		E1_KOG0153
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69245
Inparanoid	1	1.050	515	1.000	Inparanoid score	I1308
Isobase	1	0.950	-	0	Normalized mean entropy	S1481
OMA	1	1.010	-	-		QHG54734
OrthoDB	1	1.010	-	-		D1272857at2759
OrthoFinder	1	1.000	-	-		FOG0003246
OrthoInspector	1	1.000	-	-		oto89519
orthoMCL	1	0.900	-	-		OOG6_102614
Panther	1	1.100	-	-	LDO	PTHR14089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1348
SonicParanoid	1	1.000	-	-		X2658
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	18	17.750