Protein Alignment CG14641 and RBM22

DIOPT Version :10

• Sequence 1: NP_649440.3
• Gene: CG14641 / 40529
• FlyBaseID: FBgn0037220
• Length: 418
• Species: Drosophila melanogaster
• Sequence 2: NP_060517.1
• Gene: RBM22 / 55696
• HGNCID: 25503
• Length: 420
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 250/435 - (57%)
• Similarity: 312/435 - (71%)
• Gaps: 43/435 - (9%)

  Fly     1 MSMSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRF 65
            |:.|..:|||||||||||:||||||||||:|||:||.||::|||||||.||||:||||||.||||
Human     1 MATSLGSNTYNRQNWEDADFPILCQTCLGENPYIRMTKEKYGKECKICARPFTVFRWCPGVRMRF 65

  Fly    66 KKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDG 130
            ||||:||||::|||||||||||||||||||||||.|...|:||:||||||||.||::.::.:.||
Human    66 KKTEVCQTCSKLKNVCQTCLLDLEYGLPIQVRDAGLSFKDDMPKSDVNKEYYTQNMEREISNSDG 130

  Fly   131 TEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCE 195
            |...|.:|::.:.::||.|||||.|||||||||||||||||||||||||||||:||.:|||||.:
Human   131 TRPVGMLGKATSTSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLAD 195

  Fly   196 QNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRS 260
            |||||||||.|||||:|::|||:::|.|:||||:.|||||||.|.:.|||.:||:.||||||||:
Human   196 QNIKDRYYGINDPVADKLLKRASTMPRLDPPEDKTITTLYVGGLGDTITETDLRNHFYQFGEIRT 260

  Fly   261 IALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRRFDLAGI- 324
            |.:|.||||||:|:..|.|||:|||::||||::.||::::||..|||.:|...:.|...| :||
Human   261 ITVVQRQQCAFIQFATRQAAEVAAEKSFNKLIVNGRRLNVKWGRSQAARGKEKEKDGTTD-SGIK 324

  Fly   325 ------------PPPSAKPN---DYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAA 374
                        |||:|:..   :||||       .|:|           |.:...:...|
Human   325 LEPVPGLPGALPPPPAAEEEASANYFNL-------PPSG-----------PPAVVNIALPP---- 367

  Fly   375 PYGNATSTALSSSGVNLDSISIPPP----PGQVPYPSQDASRMGA 415
            |.|.|..............:..|||    ||.:.|||||..||||
Human   368 PPGIAPPPPPGFGPHMFHPMGPPPPFMRAPGPIHYPSQDPQRMGA 412

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG14641	NP_649440.3	ZnF_C3H1	159..185	CDD:214632	25/25 (100%)
		RRM_RBM22	231..304	CDD:409671	45/72 (63%)
		PABP-1234	<234..>377	CDD:130689	63/158 (40%)
RBM22	NP_060517.1	ZnF_C3H1	159..185	CDD:214632	25/25 (100%)
		RRM_RBM22	231..304	CDD:409671	45/72 (63%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	303..343		12/40 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	372..420		15/41 (37%)