DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14641 and rbm22

DIOPT Version :9

Sequence 1:	NP_649440.3	Gene:	CG14641 / 40529	FlyBaseID:	FBgn0037220	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_998379.1	Gene:	rbm22 / 406495	ZFINID:	ZDB-GENE-040426-2298	Length:	425	Species:	Danio rerio

Alignment Length:	436	Identity:	249/436 - (57%)
Similarity:	311/436 - (71%)	Gaps:	40/436 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSMSKTTNTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMRF 65
            |:.|..:||||||||||::||||||||||:|||:||.||:||||||||.||||:||||||.||||
Zfish     1 MATSLGSNTYNRQNWEDSDFPILCQTCLGENPYIRMTKEKFGKECKICARPFTVFRWCPGVRMRF 65

  Fly    66 KKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGDG 130
            ||||:||||:::|||||||||||||||||||||..|.|.|.:|:||||||||.||::.::.:.||
Zfish    66 KKTEVCQTCSKMKNVCQTCLLDLEYGLPIQVRDTGLSVKDEVPRSDVNKEYYTQNMEREIANSDG 130

  Fly   131 TEAAGAVGRSLAANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDPLCE 195
            |...|.:|::.::::||.|||||.|||||||||||||||||||||||||||||:||.:|||||.:
Zfish   131 TRPVGLLGKAPSSSDMLLKLARTTPYYKRNRPHICSFWVKGECKRGEECPYRHEKPTDPDDPLAD 195

  Fly   196 QNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNLPEEITEPELRDQFYQFGEIRS 260
            |||||||||.|||||.|::.||:::|.|:.|:|::|||||:|.|.|.:|:.|||:.||||||||:
Zfish   196 QNIKDRYYGINDPVANKLLMRASTMPRLDVPDDKSITTLYIGGLGENVTDSELRNHFYQFGEIRT 260

  Fly   261 IALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAK---TDRRFDL- 321
            |.:|.||||||:|:..|.|||.|||::||||:|.||::::||..|||.:|...|   |:....|
Zfish   261 ITIVQRQQCAFIQFATRQAAETAAEKSFNKLIINGRRLNVKWGRSQAARGKGEKDGVTESGIRLE 325

  Fly   322 ------AGIPPPSAKPND----YFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMYGQPTYAAPY 376
                  ..:|||.....|    ||||..   ...||.|.|     .|.|.....|...|.:..|.
Zfish   326 PVPGLPGALPPPPVSDEDASTNYFNLAP---TPSPAVMNL-----GLPPPPGVTMPPPPGFGPPM 382

  Fly   377 GNATSTALSSSGVNLDSIS--IPP-----PPGQVPYPSQDASRMGA 415
            .:           .:|.::  :||     |||||.|||||..||||
Zfish   383 FH-----------TMDPMAPPVPPPMALRPPGQVHYPSQDPQRMGA 417

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14641	NP_649440.3	ZnF_C3H1	159..185	CDD:214632	25/25 (100%)
		RRM	186..>309	CDD:223796	75/122 (61%)
		RRM_RBM22	231..304	CDD:240670	45/72 (63%)
rbm22	NP_998379.1	ZnF_C3H1	159..185	CDD:214632	25/25 (100%)
		RRM	186..>307	CDD:223796	73/120 (61%)
		RRM_RBM22	231..304	CDD:240670	45/72 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	304..331		7/26 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..425		17/45 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170576453
Domainoid	1	1.000	388	1.000	Domainoid score	I758
eggNOG	1	0.900	-	-		E1_KOG0153
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69245
Inparanoid	1	1.050	513	1.000	Inparanoid score	I1269
OMA	1	1.010	-	-		QHG54734
OrthoDB	1	1.010	-	-		D1272857at2759
OrthoFinder	1	1.000	-	-		FOG0003246
OrthoInspector	1	1.000	-	-		oto40537
orthoMCL	1	0.900	-	-		OOG6_102614
Panther	1	1.100	-	-	LDO	PTHR14089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1348
SonicParanoid	1	1.000	-	-		X2658
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800