DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG14641 and rbm-22

DIOPT Version :9

Sequence 1:	NP_649440.3	Gene:	CG14641 / 40529	FlyBaseID:	FBgn0037220	Length:	418	Species:	Drosophila melanogaster
Sequence 2:	NP_502014.2	Gene:	rbm-22 / 177979	WormBaseID:	WBGene00011722	Length:	408	Species:	Caenorhabditis elegans

Alignment Length:	436	Identity:	211/436 - (48%)
Similarity:	291/436 - (66%)	Gaps:	55/436 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSMSKTT-NTYNRQNWEDAEFPILCQTCLGDNPYVRMIKERFGKECKICTRPFTIFRWCPGARMR 64
            |||||:: :.|||:||||::|||||:||||:|||:||:|:::|:|||||.||||.|||.||...|
Worm     1 MSMSKSSYSQYNRKNWEDSDFPILCETCLGNNPYMRMMKDKYGRECKICERPFTTFRWQPGKGAR 65

  Fly    65 FKKTEICQTCARLKNVCQTCLLDLEYGLPIQVRDAALKVADNMPQSDVNKEYYIQNIDAQLQDGD 129
            :|.||:|||||::|||||||:.|||||||:||||..|::|||:|:...|:::::||::..|..||
Worm    66 YKNTELCQTCAKVKNVCQTCMFDLEYGLPVQVRDHELQIADNIPKQGANRDFFLQNVERTLGQGD 130

  Fly   130 GTEAAGAVGRSL--AANEMLSKLARTAPYYKRNRPHICSFWVKGECKRGEECPYRHDKPNEPDDP 192
            ||:....:..::  ||::.|.::.||.||||||.||||||:|||||||||||||||:||.:||||
Worm   131 GTQPIAQIANNMDQAAHDRLRRMGRTQPYYKRNAPHICSFFVKGECKRGEECPYRHEKPTDPDDP 195

  Fly   193 LCEQNIKDRYYGRNDPVAEKIMKRAASLPTLEPPEDRNITTLYVGNL----PEEITEPELRDQFY 253
            |..|||:|||||.||||||||:.|||:.|||.||.|..|||||:|||    .:::||.:|.|.||
Worm   196 LSRQNIRDRYYGTNDPVAEKILNRAAAAPTLSPPADTTITTLYIGNLGPSGAQQVTEKDLNDFFY 260

  Fly   254 QFGEIRSIALVPRQQCAFVQYTKRNAAELAAERTFNKLVIQGRKVSIKWAHSQAKQGTAAKTDRR 318
            |:|:||.:.::..:.|||:::|.|.|||.||||:|||..|:|::::|:|...|||:
Worm   261 QYGDIRCLRVLTEKGCAFIEFTTREAAERAAERSFNKTFIKGKRLTIRWGEPQAKR--------- 316

  Fly   319 FDLAGIPPPSAKPNDYFNLRQEQINVMPAGMKLHQLPSNLVPASAYQMY---------GQPTYAA 374
                      |..|..:......:.::|       :|..|.|:::.|..         ..||:||
Worm   317 ----------AADNSNYVTPVPSVPILP-------VPDGLAPSTSSQQRFTGSMPRPPAPPTFAA 364

  Fly   375 PYGNATST-----ALSSSGVNLDSISIPPPPGQVPYPSQDASRMGA 415
            |.......     |..|||.:..|        .:.|||||.:|:||
Worm   365 PRSLVVPNVRPVKAGESSGASSSS--------SIYYPSQDPTRLGA 402

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14641	NP_649440.3	ZnF_C3H1	159..185	CDD:214632	23/25 (92%)
		RRM	186..>309	CDD:223796	70/126 (56%)
		RRM_RBM22	231..304	CDD:240670	37/76 (49%)
rbm-22	NP_502014.2	ZnF_C3H1	165..188	CDD:214632	21/22 (95%)
		RRM	<214..>322	CDD:223796	54/126 (43%)
		RRM_RBM22	234..311	CDD:240670	37/76 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160157675
Domainoid	1	1.000	201	1.000	Domainoid score	I1764
eggNOG	1	0.900	-	-		E1_KOG0153
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H69245
Inparanoid	1	1.050	432	1.000	Inparanoid score	I959
Isobase	1	0.950	-	0	Normalized mean entropy	S1481
OMA	1	1.010	-	-		QHG54734
OrthoDB	1	1.010	-	-		D1272857at2759
OrthoFinder	1	1.000	-	-		FOG0003246
OrthoInspector	1	1.000	-	-		oto20449
orthoMCL	1	0.900	-	-		OOG6_102614
Panther	1	1.100	-	-	LDO	PTHR14089
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1348
SonicParanoid	1	1.000	-	-		X2658
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790