Protein Alignment aux and STK16

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_001008910.1
• Gene: STK16 / 8576
• HGNCID: 11394
• Length: 305
• Species: Homo sapiens
• Alignment Length: 306
• Identity: 79/306 - (25%)
• Similarity: 139/306 - (45%)
• Gaps: 44/306 - (14%)

  Fly    47 GHRLRIKCV------------------IAEGGYAFVYVAQDVQTGTEYALKRLIGADMQASTAII 93
            ||.|   ||                  :.|||:::|.:.:.:..|..|||||::..:.|......
Human     2 GHAL---CVCSRGTVIIDNKRYLFIQKLGEGGFSYVDLVEGLHDGHFYALKRILCHEQQDREEAQ 63

  Fly    94 NEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQY--LLLTELCKGGSL---VDCFRTNNAPFNPT 153
            .|.::|: |..|.||:..|  :|..  .:.||::  .||....|.|:|   ::..:.........
Human    64 READMHR-LFNHPNILRLV--AYCL--RERGAKHEAWLLLPFFKRGTLWNEIERLKDKGNFLTED 123

  Fly   154 CVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQR 218
            .:|.:...:.|.:.::|::.  .||||:|..|.|:|::.|..|.|.||.:...:...   .:.|.
Human   124 QILWLLLGICRGLEAIHAKG--YAHRDLKPTNILLGDEGQPVLMDLGSMNQACIHVE---GSRQA 183

  Fly   219 SMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYE------DGGKLR 277
            ..|:|......|..||:||:....|:..|..:.|:|:|||:||.:.:.:.||:      |...|.
Human   184 LTLQDWAAQRCTISYRAPELFSVQSHCVIDERTDVWSLGCVLYAMMFGEGPYDMVFQKGDSVALA 248

  Fly   278 IINANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDITMVLEGLAAL 322
            :.| ...:|..|:: .....::...:.|:|.:|..|.::|..|.||
Human   249 VQN-QLSIPQSPRHSSALRQLLNSMMTVDPHQRPHIPLLLSQLEAL 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	77/304 (25%)
		PTP_auxilin-like	404..573	CDD:350361
		PTEN_C2	581..711	CDD:463081
		PHA03247	<698..1037	CDD:223021
		Herpes_BLLF1	<882..>999	CDD:282904
		DnaJ	<1110..1150	CDD:99751
STK16	NP_001008910.1	STKc_16	19..295	CDD:270888	74/286 (26%)
		Activation loop	166..202		9/38 (24%)