DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and ARK1

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_014378.1	Gene:	ARK1 / 855711	SGDID:	S000004965	Length:	638	Species:	Saccharomyces cerevisiae

Alignment Length:	461	Identity:	124/461 - (26%)
Similarity:	204/461 - (44%)	Gaps:	62/461 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    39 VGQVVEVAGHRLRIKCVIAEGGYAFVYVA----QDVQTGTEYA-LKRLIGADMQASTAIINEINI 98
            ||..:.|..|::.|...:..||:|.||.|    .|..:.:..| |||:|..|..:...:..|::.
Yeast    11 VGTQLTVGSHQVEIIKYLTSGGFAQVYSALINPPDPHSNSSVACLKRVIVPDKPSLNTLRAEVDA 75

  Fly    99 HKQLSGHENIVAFVGSSYTAPSTQLGA-QYLLLTELCKGGSLVDCFRTN-NAPFNPTCVLRIFYQ 161
            .:.|..:..:|:::.|.........|: :..:|.|.|:.|.|:|...|. ....:...:|:|..|
Yeast    76 MRLLKNNRYVVSYIDSHAAKAMLHNGSYEVFVLMEYCERGGLIDFMNTRLQNRLHEFEILQIMSQ 140

  Fly   162 MARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQRSMLEDQLN 226
            :.:.||::|:..||:.||||||||.||..:.:.|||||||....:..|.   ::.:.|.::..:.
Yeast   141 VTQGVAAMHALQPPLIHRDIKIENVLISANNEYKLCDFGSVCGIIRPPR---NSQELSYVQQDIL 202

  Fly   227 TVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPDPQY 291
            ..||..||||||:||:...||..|.||||||..||.|||...|:|.||.|.|::..:..|..|.|
Yeast   203 KNTTAQYRSPEMIDTFRGLPIDEKSDIWALGIFLYKLCYYTTPFEKGGDLAILSGKFEFPLYPNY 267

  Fly   292 -QCFSDIIRGCLKVNPFERLDITMVLEGLAA----------------------LAETHN------ 327
             :....:||..|..:|..|.::..:|:.::.                      |.|.|.
Yeast   268 SEQLKGLIRDILVQDPRHRPNVYQLLKRISIMQNVPCPINDIQVVQAPSSHLNLTELHQLSATQN 332

  Fly   328 -WSLKGPLDLHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNGHGSLLSSLRGGAGTLLKN 391
             .||..|..:.    .::|..:...|.|.:....:......||......|..:|.:|.     :.
Yeast   333 ILSLNSPTTME----NTMPNATFQISMADNTTTAQMHPNRKPSQIAYDASFSNSAKGS-----QP 388

  Fly   392 IKDTSTK--------VMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLE 448
            :.|.|..        :::.:..|::.||.::...::..|.....|:.  .|::.||..|..|
Yeast   389 LFDKSQNMYHALDPPLVEPLASSVSNNDNELKANSATKLKQAIVSEA--HTFRQNNSIDFPL--- 448

  Fly   449 SRFVPQ 454
            ...:||
Yeast   449 QNIIPQ 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357	94/306 (31%)
		S_TKc	51..317	CDD:214567	91/273 (33%)
		PTEN_C2	581..711	CDD:287393
		DnaJ	<1110..1150	CDD:197617
ARK1	NP_014378.1	STKc_NAK_like	18..301	CDD:270939	93/285 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810