DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and TDA1

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_014019.1	Gene:	TDA1 / 855336	SGDID:	S000004905	Length:	586	Species:	Saccharomyces cerevisiae

Alignment Length:	539	Identity:	122/539 - (22%)
Similarity:	193/539 - (35%)	Gaps:	176/539 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    56 IAEGGYAFVYVAQDVQTGTEYALK-----------RLIGADMQASTAIINEI------NIHKQ-- 101
            :.:|.::.|....::.|...||:|           :||..:.....:|..:|      |.|..
Yeast    45 LGDGNFSVVKECMNIHTKDLYAMKLIKKQTVKNKIQLIQREFDLLRSISEKIRDMEKKNEHSLDI 109

  Fly   102 LSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCFRTNNAPFNPTCVLRIFYQMARAV 166
            ..||.:|:.......||.:      .:|:|:||:.|.|.:....|......|.|......:...:
Yeast   110 FEGHHHILQLFDYFETADN------IVLITQLCQKGDLYEKIVENQCLDLETQVTSYCACLVSVL 168

  Fly   167 ASLHSQSPPIAHRDIKIENFLI-----GNDKQIK-----------------LCDFGSASTEVLSP 209
            ..||||.  |.|||:|.||.|.     .|:|.::                 |.|||.|:
Yeast   169 EFLHSQG--IVHRDLKAENVLFRLRVNENEKNLQGEHHGDFKYDLLAHDLVLADFGLAA------ 225

  Fly   210 TFEWSANQRSMLEDQLNTVTTPMYRSPEM----------------LDTWSNNPIGPKVDIWALGC 258
              |::.::.:.|::.:.|::   |.:||:                ||.:     |..|||||||.
Yeast   226 --EYNTSKVNSLKEFVGTIS---YIAPEIVKCKGVGEMTPDQVGKLDKY-----GCPVDIWALGV 280

  Fly   259 ILYFLCYRKHPYE---DGGKLRIIN-----ANYMLPPDPQYQCFSDIIRGC-------------L 302
            :.||:.:...|::   |...|..|:     .:..:..||:|:.|.:.::.|             |
Yeast   281 LTYFMAFGYTPFDCTTDDETLECISKCDYYVDEQMMHDPKYEQFWNFVQCCFTIDPAVRRSAKNL 345

  Fly   303 KVNPFERLDITMVLEGLAALAETHNWS-------LKGPLDLHIMPIESLPAESPLKSS-----AY 355
            |.:||.: |.......|.. .:|.|:|       :.....:|.:       .||.||.     ||
Yeast   346 KQHPFIK-DYFATSNSLNT-KDTPNFSFHPTIRRVSSTASMHTL-------RSPSKSRKTTTLAY 401

  Fly   356 -------SEVYTEPLSAA-IPSSY-----NGHGSLLSSLRGGAGTLLKNIKDTSTKVMQTMQQSL 407
                   ||..|...|.. :|..|     |.....|:.:|   .||.|.:..||.|...|.....
Yeast   402 LNMDGGSSETSTAFSSKMDLPDLYVDRTINSRERSLNRIR---DTLKKTLSMTSLKPAGTFDYLH 463

  Fly   408 A-RNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFV----PQKLSIYNFGQRTEP 467
            | :|...:|...|.::             |.|          |.||    |.|.|:.|....|.|
Yeast   464 ANKNGTSLSSSKSGLV-------------KKN----------STFVLDPKPPKNSLMNGCFSTTP 505

  Fly   468 RLPPPVRTVEAGSVYGCPQ 486
                     |:.|.:..|:
Yeast   506 ---------ESRSNFNTPK 515

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357	78/347 (22%)
		S_TKc	51..317	CDD:214567	77/338 (23%)
		PTEN_C2	581..711	CDD:287393
		DnaJ	<1110..1150	CDD:197617
TDA1	NP_014019.1	STKc_CAMK	37..350	CDD:270687	74/328 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000