Protein Alignment aux and PRK1

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_012171.1
• Gene: PRK1 / 854713
• SGDID: S000001357
• Length: 810
• Species: Saccharomyces cerevisiae
• Alignment Length: 567
• Identity: 151/567 - (26%)
• Similarity: 231/567 - (40%)
• Gaps: 134/567 - (23%)

  Fly    40 GQVVEVAGHRLRIKCVIAEGGYAFVYVAQ----DVQTGTEYA-LKRLIGADMQASTAIINEINIH 99
            |.::.|..|..:|...:..||:|.||.|:    |..:....| |||:|....|....:..|::..
Yeast    12 GTILTVGSHHAKIIKYLTSGGFAQVYTAEISPPDPYSNANIACLKRVIVPHKQGLNTLRAEVDAM 76

  Fly   100 KQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCFRTN-NAPFNPTCVLRIFYQMA 163
            |.|..::::|:::.|........:..:..:|.|.|:.|.|:|...|. ......:.:|.|..|..
Yeast    77 KLLRNNKHVVSYIDSHAARSVNGIAYEVFVLMEFCERGGLIDFMNTRLQNRLQESEILEIMSQTV 141

  Fly   164 RAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSP--TFEWSANQRSMLEDQLN 226
            :.:.::|:..||:.||||||||.||.:|...|:|||||.|..:..|  |.|::..|..:|
Yeast   142 QGITAMHALQPPLIHRDIKIENVLISHDGLYKVCDFGSVSGVIRPPRNTQEFNYVQHDIL----- 201

  Fly   227 TVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANYMLPPDPQY 291
            |.||..||||||:|.:...||..|.||||||..||.:||...|:|..|:..|::|.|..|..|||
Yeast   202 TNTTAQYRSPEMIDLYRGLPIDEKSDIWALGVFLYKICYYTTPFEKSGEAGILHARYQYPSFPQY 266

  Fly   292 -QCFSDIIRGCLKVNPFERLDITMVLEG----------------LAALAETHNWSLKG------- 332
             ....::||..|...|.:|.:|..|||.                |.|:.:..|..|.|
Yeast   267 SDRLKNLIRLMLMEAPSQRPNICQVLEEVSRLQNKPCPIRNFYLLRAMNQNANTQLAGEPSSTTY 331

  Fly   333 -PLDLHIMPIESLPA-ESPLKSSAYSEVYTEPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDT 395
             |....| |::||.: ..|......:.|.|.|.....|.|.|.:..  :.:...||..:.:..:.
Yeast   332 VPTQKFI-PVQSLQSINQPPNMMPVTHVSTTPNLGTFPISINDNNK--TEVTAHAGLQVGSHSNL 393

  Fly   396 STKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTY--------KTNNIEDVRLSLESRFV 452
            ::.:|:|....|                    ||.|.|.|        |:...:    |:||...
Yeast   394 TSPLMKTKSVPL--------------------SDEFASLYYKELHPFQKSQTFK----SVESFQS 434

  Fly   453 PQKLSIYNFGQRTEPRLPP----PVR------------------------------------TVE 477
            ||:.|           :||    ||.                                    |:.
Yeast   435 PQRKS-----------MPPLSLTPVNNDIFDRVSAINRPNNYVDSETQTIDNMAVPNLKLSPTIT 488

  Fly   478 AGSVYGCPQAHAP-NLQGLFTVSADMYNFLNADPKSVVIVQTGDSGG 523
            :.|:....:..|| |:.|     :.:...|::..|.|:   ||:|.|
Yeast   489 SKSLSSTKEIAAPDNING-----SKIVRSLSSKLKKVI---TGESRG 527

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	99/301 (33%)
		PTP_auxilin-like	404..573	CDD:350361	30/169 (18%)
		PTEN_C2	581..711	CDD:463081
		PHA03247	<698..1037	CDD:223021
		Herpes_BLLF1	<882..>999	CDD:282904
		DnaJ	<1110..1150	CDD:99751
PRK1	NP_012171.1	STKc_NAK_like	18..300	CDD:270939	98/286 (34%)