Protein Alignment aux and AKL1

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_009615.1
• Gene: AKL1 / 852351
• SGDID: S000000263
• Length: 1108
• Species: Saccharomyces cerevisiae
• Alignment Length: 1245
• Identity: 257/1245 - (20%)
• Similarity: 428/1245 - (34%)
• Gaps: 363/1245 - (29%)

  Fly    40 GQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEY--------------ALKRLIGADMQAST 90
            |.:|.|..|::.:...:||||:|.:||.:.::...|:              .|||::..|.....
Yeast    25 GHIVCVGTHKVEVVNYLAEGGFAQIYVVKFLEYLNEFDNTASVPLKIGDVACLKRVLVQDENGLN 89

  Fly    91 AIINEINIHKQLSGHENIVAFVGSSYTAPSTQL-GAQYLLLTELCKGGSLVDCFRTN-NAPFNPT 153
            .:.||:.:.|:|.|..|||.:..|:.:.....: |.:.|||.|||...||:|..... :......
Yeast    90 EMRNEVEVMKKLKGAPNIVQYFDSNASRRRDGVQGFEVLLLMELCPNKSLLDYMNQRLSTKLTEA 154

  Fly   154 CVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQR 218
            .:::|.|.:|.:::.:|.....:.||||||||.|:......||.||||.||.....|   :....
Yeast   155 EIVKIMYDVALSISQMHYLPVSLIHRDIKIENVLVDAKNNFKLADFGSTSTCFPIVT---THQDI 216

  Fly   219 SMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLRIINANY 283
            ::|...:...|||.||||||:|.:...||..|.||||||..||.|.:...|:|..|:..|:::.|
Yeast   217 ALLTQNIYVHTTPQYRSPEMIDLYRCLPINEKSDIWALGVFLYKLLFFTTPFEMTGQFAILHSKY 281

  Fly   284 MLPPDPQYQCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPLDLHIMPIESLPAES 348
            ..|.:.......::|...|..||..|.:|..||..|..:....            :|||...||.
Yeast   282 EFPVNKYSSKLINLIIIMLAENPNLRPNIYQVLYHLCEILNVE------------VPIEDKYAEG 334

  Fly   349 PLKSSAYSEVYTEPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDTSTKVMQTMQQSLARNDLD 413
            ....|.|::...:                           |:|::   .::.|..|:.:.:|: .
Yeast   335 AYNFSKYTQFQNK---------------------------LQNVQ---LQMYQLQQKKIMQNN-K 368

  Fly   414 ISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEA 478
            :|.....:|     :|.|.|:::.::...:..| :......::...|.||..|
Yeast   369 LSDSEENLL-----NDMFLSSFEISSKLPMNAS-DGHAAVSRIPSQNVGQELE------------ 415

  Fly   479 GSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREP 543
                  .:..:.:.|...|:|.|         ||.......:|.| ||              ..|
Yeast   416 ------EEKESQSDQRKSTLSED---------KSSRTTSNANSSG-TA--------------NNP 450

  Fly   544 ED--AVQVFAVKRHTI--NLRPSEFRYLYYFGDILRPT-PLLPHYKNTTLVSLSCQPV-----PR 598
            ::  .:|...::..:|  |..|.|   |||      |: ..|..|.:..||..|..|.     ||
Yeast   451 QEINTIQSPGIEDKSIFENKTPGE---LYY------PSVSELDTYLDKELVKQSSDPTISEQSPR 506

  Fly   599 MTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTV----VLFHAR 659
            :...                  |..|..:....|.:| |:   .:..|:.|..|:    .|.:.:
Yeast   507 LNTQ------------------SLPQRQKSTSSYSSG-GR---SMKSTSYGAATIGSDEALANEK 549

  Fly   660 KGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLP----DPEQVTPRFCVSLSLAVTDSES 720
            ...:.    |:.|.:.|..| |:.......||:..:|..    :.:|...|:..:.:...|...:
Yeast   550 TAGIN----KMKQHKSNNPF-PKMNVAYHSTNELSNDASNFFLEEQQQGQRYQQAQNQTGTQGNT 609

  Fly   721 PPS--------HKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVT------KPSTRSSPPPGARKS 771
            .|.        .:......:|| .||       .|::.  ||.|      ||........|...:
Yeast   610 FPDESQYQSRVEQQQQQQDQPK-GPA-------NYSQR--NFYTGRDRSNKPMQLGGTIAGDSGN 664

  Fly   772 DRVSSPLVLPDVTETAHE--LPS------PMPEPSPPIDLLNLNQQPSDVPAADPLTS----AKP 824
            .||:...:..:....:..  |||      ||..|     ::::|||.:....|..|.:    ||.
Yeast   665 RRVNFQNISQNYATNSQSGYLPSQNSPAIPMVRP-----VISMNQQQAQQIQAQQLQAQQMQAKQ 724

  Fly   825 STDASFDLLGAFGDDDSTGIGSAPIPDILPPPPLQQPQPKINNDPF----------DIFGSVDQG 879
            ...|...:               .:...|......|.|...||..:          |:..:  ||
Yeast   725 QMQAKQQM---------------QVQQQLQVQQQMQIQNANNNGTYVSDRTNHTTEDMRNA--QG 772

  Fly   880 GVPSMKPSGFPPFVGSLPTFVAQPAATTNPSPTHPARASADPFANIADLA--------------- 929
            |.|       |...|:              |...|..:|:...|.:.:|:
Yeast   773 GEP-------PILAGN--------------SANEPMHSSSKNEALLIELSPLKEDAGKQSFQDTN 816

  Fly   930 ---TG---------------------LNLNFNRSTLSGKSPVNTSPQPTQFSSPTHKPSPSSQPQ 970
               ||                     |||:.|...||..   :|....:.|||.:   |.:|..|
Yeast   817 EPQTGGIEDAGGSGTIKGSNNNRNGVLNLSLNEMDLSRD---DTGAAVSSFSSSS---SSASIQQ 875

  Fly   971 ATF-----------MHTPPTPQTLPSTSSIRTPTQP--QAVPAQSRPDYS-RLHFDSQKAAQQPG 1021
            |..           ..|.....::.|:.||......  :...|:.||.:: |.|.|..:::....
Yeast   876 AKLSGRKGSSKRNNYSTDELGDSMVSSESIDIDLDDARRGKTAERRPLHNERGHKDQARSSDASK 940

  Fly  1022 TGGSKNSDIFADILGQQGYSFGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRAL 1086
            :...|:.|..:....|...|......:...|...:.:|...|:..|           ..|:..:.
Yeast   941 SNQFKSKDFSSVSTRQPRQSLDLNFQEVNLSSPTLTQEHRNKNDSP-----------APNSHHSY 994

  Fly  1087 LCSMH--TVLWDNAKW----------------------QRCEMS----------------TMVTP 1111
            ..|.|  |.:.:|.:.                      ||.::.                :..||
Yeast   995 RVSPHASTAITENKRHSTGHELSTRSNGKHETHRTGSKQRHDLERYRHSKDKDSNSSITISTSTP 1059

  Fly  1112 TEVKKAYRRA 1121
            :|::|::.||
Yeast  1060 SEMRKSFARA 1069

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	91/292 (31%)
		PTP_auxilin-like	404..573	CDD:350361	31/172 (18%)
		PTEN_C2	581..711	CDD:463081	26/142 (18%)
		PHA03247	<698..1037	CDD:223021	76/431 (18%)
		Herpes_BLLF1	<882..>999	CDD:282904	28/168 (17%)
		DnaJ	<1110..1150	CDD:99751	6/12 (50%)
AKL1	NP_009615.1	STKc_NAK_like	31..322	CDD:270939	92/293 (31%)