DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and SWA2

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_010606.1	Gene:	SWA2 / 851918	SGDID:	S000002728	Length:	668	Species:	Saccharomyces cerevisiae

Alignment Length:	554	Identity:	118/554 - (21%)
Similarity:	182/554 - (32%)	Gaps:	194/554 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   677 TGFIPEPETLITFTNQDLD-----DLPDPEQVTPRFCVSLSLAVTDSE----SPPSHKPPWMPAK 732
            |.|.||....:...::..|     |||.......|      :...|:|    .||:..|.
Yeast   233 TSFPPEANDRLNNYSKTHDKVEDYDLPQVNDSPNR------ILFEDNEVVENLPPADNPD----- 286

  Fly   733 PKRSPAALFSSDLEYAEMLDNFVTK-PSTRSSPPPGARKSDRVSSPLVLPDVTETAHELPSPMPE 796
                           .::|.:|.|| ..|:.:.|..:..|...|..|:         |..|...|
Yeast   287 ---------------QDLLTDFETKIDITKRTAPDVSHSSSPTSGILI---------EENSRRNE 327

  Fly   797 PSPPIDLLNLNQQPSDVPAADPLTSAKPSTDASFDLLGAFGDDDSTGIGSAPIPDILPPPPLQQP 861
            |.....||:.::        ..||::|.:.|::.     |.::.:|. .:.||.||
Yeast   328 PLIEDSLLDFSE--------GNLTNSKSNEDSTL-----FNENSNTD-STIPISDI--------- 369

  Fly   862 QPKINNDPFDIFGSVDQGGVPSMKPSGFPPF-----VGSLPTFVAQPAATTNPSPTHPARASADP 921
                           :..|....|..|...|     :.||..:  :.:..|.|. .||.|..|
Yeast   370 ---------------ELSGYNEFKAKGTSLFKNGDYINSLQEY--EKSLNTLPL-NHPLRIIA-- 414

  Fly   922 FANIADLATGLNLN---------------FNRSTLSGKSPVNTSPQPTQFS------------SP 959
            .:||  :|:.|.:.               |..|....|:.::.|.....|:            |.
Yeast   415 LSNI--IASQLKIGEYSKSIENSSMALELFPSSKAKWKNKISNSDPERSFNDIWPKIMIRRAESF 477

  Fly   960 TH----------------------KPSPSSQPQATFMHTPPTPQTLPSTSSIRTPTQPQAVPAQS 1002
            .|                      |.....:....|::.||..:::|......|.:     ||..
Yeast   478 EHLESFKKALETYQELIKKNFFDDKIMQGKRRCQDFINPPPVKKSMPVKKKTTTTS-----PATK 537

  Fly  1003 RPDYSRLHFDSQKAAQQPGTGGSKNSDIFADILGQQGYSFGSKMNQCPRSINEMRKEDL----FK 1063
            :               |..|..|.||.|..|                  |.:|::|.:|    ..
Yeast   538 K---------------QNLTASSSNSPISVD------------------STSEIKKRELENAKLA 569

  Fly  1064 DMDPKKVRIMEWTDGKKNNIRALLCSMHTVL-WDNAKWQRCEMSTMVTPTEVKKAYRRACLAVHP 1127
            ..|....:|..|.|||.::||.||.::.::| |.|  |:...|..:|.|..||..|.:|....||
Yeast   570 LYDKVFEKISSWKDGKDDDIRHLLANLSSLLTWCN--WKDVSMQDLVMPKRVKITYMKAVAKTHP 632

  Fly  1128 DK---HNGTENEEIAKLIFMELNNAWTDF--END 1156
            ||   ....||:.||:.||..|:.||..|  :||
Yeast   633 DKIPESLSLENKMIAENIFSTLSIAWDKFKLQND 666

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	9/38 (24%)
		DnaJ	<1110..1150	CDD:197617	16/42 (38%)
SWA2	NP_010606.1	Ubiq-assoc	138..181	CDD:401184
		TPR	<374..497	CDD:223533	22/129 (17%)
		TPR repeat	374..402	CDD:276809	5/29 (17%)
		TPR repeat	407..441	CDD:276809	8/37 (22%)
		TPR repeat	467..495	CDD:276809	2/27 (7%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157346205
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0431
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001565
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23172
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.930