DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment aux and Gak

DIOPT Version :9

Sequence 1:NP_649438.1 Gene:aux / 40527 FlyBaseID:FBgn0037218 Length:1165 Species:Drosophila melanogaster
Sequence 2:NP_112292.1 Gene:Gak / 81659 RGDID:621589 Length:1305 Species:Rattus norvegicus


Alignment Length:1341 Identity:471/1341 - (35%)
Similarity:661/1341 - (49%) Gaps:241/1341 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    16 SEVNGAAGNGAPEALGGRLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEYALKR 80
            |.::..||.|:.....||..:|||||.||:...|||::.|:||||:||||.|||:.:|.||||||
  Rat     6 SALDFLAGPGSLGGAAGRDQSDFVGQTVELGELRLRVRRVLAEGGFAFVYEAQDLGSGREYALKR 70

  Fly    81 LIGADMQASTAIINEINIHKQLSGHENIVAFV-GSSYTAPSTQLG-AQYLLLTELCKGGSLVDCF 143
            |:..:.:.:.|||.|:...|:||||.|||.|. .:|.....:..| |::|||||||| |.||:..
  Rat    71 LLSNEEEKNRAIIQEVCFLKKLSGHPNIVQFCSAASIGKEESDTGQAEFLLLTELCK-GQLVEFL 134

  Fly   144 R--TNNAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEV 206
            |  ....|.:...:|:||||..|||..:|.|.|||.|||:|:||.|:.|...|||||||||:|..
  Rat   135 RRVECKGPLSCDSILKIFYQTCRAVQHMHRQKPPIIHRDLKVENLLLSNQGTIKLCDFGSATTIS 199

  Fly   207 LSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYE 271
            ..|.:.|||.:|:|:|:::...||||||:||::|.:||.|||.|.||||||||||.||:|:||:|
  Rat   200 HYPDYSWSAQKRAMVEEEITRNTTPMYRTPEIVDLYSNFPIGEKQDIWALGCILYLLCFRQHPFE 264

  Fly   272 DGGKLRIINANYMLP-PDPQYQCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPLD 335
            ||.||||:|..|.:| .|.:|..|.|:|||.|||||.|||.|..|:..|..:|...|.:.|.|: 
  Rat   265 DGAKLRIVNGKYSIPVNDTRYTVFHDLIRGMLKVNPEERLSIAEVVRQLQEIAAARNVNPKAPI- 328

  Fly   336 LHIMPIESL----------------PAESPLKSS---AYSEVYTEPLSAAIPSSYNGHGSLLSSL 381
                 .|.|                |:..|:.||   |.:| |.:|           :|..|..|
  Rat   329 -----TELLEQNGGYGNSGPSRAQPPSGGPVNSSGVLALAE-YDQP-----------YGGFLDIL 376

  Fly   382 RGGAGTLLKNIKDTSTKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLS 446
            |||...|..|:||||:||:|:: .:.|:.|||||:|||||.||..|::|.||..| ||||||||.
  Rat   377 RGGTERLFTNLKDTSSKVIQSV-ANYAKGDLDISYITSRIAVMSFPAEGVESAIK-NNIEDVRLF 439

  Fly   447 LESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPK 511
            |:::. |...::||...|.........|..|.|...    ..||:|..|:|:...|:.:|..|.:
  Rat   440 LDAKH-PGHYAVYNLSPRIYRASKFHNRVTECGWAV----RRAPHLHSLYTLCRSMHAWLREDHR 499

  Fly   512 SVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRP 576
            :|.:|...| |...:|..:||.|.:..|....|.||.:|::||....:.||..||:.|..|::..
  Rat   500 NVCVVHCMD-GRAASAVAVCAFLCFCRLFSTAEAAVYMFSMKRCPPGIWPSHKRYIEYVCDMVAE 563

  Fly   577 TPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVL 641
            .|:.||.|...:.|:...|||..:|.|:|||.:.|||.....:.:|.|:|::|:.::...||.|:
  Rat   564 EPITPHSKPMLVKSVVMTPVPLFSKQRNGCRPFCEVYVGEERVTTTSQEYDRMKEFKIEDGKAVI 628

  Fly   642 PINLTACGDVTVVLFHARKGM-----VRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPE 701
            |:.:|..|||..:::|||..:     .:...:|:.|.||:|||:|...|.:.|...|||.....|
  Rat   629 PLGITVQGDVLTIIYHARSTLGGRLQAKMASMKMFQIQFHTGFVPRNATTVKFAKYDLDACDIQE 693

  Fly   702 QVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPK-RSPAALFSSDLEYAEMLDNFVTKPSTRSSPP 765
            :....|.|:|.:.|...:.|....|||.....: .:|..|||:..|..::|..| .||.....|.
  Rat   694 KYPDLFQVNLEVEVEPRDRPSRDVPPWENTSLRGLNPKILFSNREEQQDILSKF-GKPELPRQPG 757

  Fly   766 PGARKSDRVSSPLVLPDVTE----------TAHEL------------------------------ 790
            ..|:......||..  ::||          |.|.|                              
  Rat   758 STAQYDAEAGSPEA--EITESDSPQSSSTDTNHFLHTLDWQEEKDPETGVDNTSPKESQSNLIAD 820

  Fly   791 ------------------------------------------------PSPMPEPSPPIDLLNLN 807
                                                            |....:|...:|||.|:
  Rat   821 GDGSEVSDEEEASCPSEERKPGAGEDTPRLAAGTRQQDLIFDVGMLAAPQEPVQPEEGVDLLGLH 885

  Fly   808 QQPSDVPAADPLTSAKPSTDASFDLLGAFGD-DDSTGIGSAPIPDIL---PPPPLQQP------- 861
            .:....|||....|...|::.  |||.:..: .|::.:|  |..|:|   .|..|..|       
  Rat   886 SEGDLRPAAPLQASGVQSSNT--DLLSSLLEPSDASQVG--PPGDLLGGETPLLLASPVSLLGVQ 946

  Fly   862 ---QPKINN--DPFDIF---GSVDQGGVPSMKPSGFPPFVG--SLPTFVAQPAATTNPSPT---- 912
               |.|:.:  ||||.|   .|.|.  .|..||..|..|:.  |:.:..|.|:..:.|.|:    
  Rat   947 SNLQGKVPDTVDPFDQFLLPSSSDT--QPCSKPDLFGEFLNSDSVASSTAFPSTHSAPPPSCSTA 1009

  Fly   913 --HPARASADPFANIA-----DLATGLNLNFNRSTLSGKS--PVNTSPQPTQFSSPTHKPSPSSQ 968
              |.....|:|...||     ||..|.: .:..:.|.|.:  ||   |:.|.|||..|...|...
  Rat  1010 FLHLGDLPAEPNKVIASSSHPDLLGGWD-TWAETALPGPASMPV---PEGTLFSSAGHPAPPGPN 1070

  Fly   969 PQATFMHTPP--------------TPQTLPSTSSIRT---------------PT------QPQAV 998
            |..|....|.              .|..||:.|.:.|               ||      .|||.
  Rat  1071 PSQTKSQNPDPFADLSDLSSSLQGLPAGLPAGSFVGTSATTHKSNSSWQTTRPTAPGTSWPPQAK 1135

  Fly   999 PAQSRPDYSRLHFDSQKAAQQPGTGG---------SKNSDIFADILGQQGYSFGSKMNQCPRSIN 1054
            ||....:..|.||....|.::.|...         |:|.  |.|:|..||:|...|..  |:::.
  Rat  1136 PAPRASEQLRSHFSVIGAREERGVRAPSFAQKPKVSEND--FEDLLPNQGFSKSDKKG--PKTMA 1196

  Fly  1055 EMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLWD-NAKWQRCEMSTMVTPTEVKKAY 1118
            ||||::|.:|.||.|:::::|.:||:.||||||.::|||||| .::|....|:.:|||.:|||.|
  Rat  1197 EMRKQELARDTDPFKLKLLDWIEGKERNIRALLSTLHTVLWDGESRWTPVSMADLVTPEQVKKQY 1261

  Fly  1119 RRACLAVHPDKHNGTENEEIAKLIFMELNNAWTDFENDATQ 1159
            |||.|.|||||..|...|:.||:||||||:||::|||..::
  Rat  1262 RRAVLVVHPDKATGQPYEQSAKMIFMELNDAWSEFENQGSR 1302

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
auxNP_649438.1 PKc_like 49..326 CDD:304357 149/281 (53%)
S_TKc 51..317 CDD:214567 145/270 (54%)
PTEN_C2 581..711 CDD:287393 46/134 (34%)
DnaJ <1110..1150 CDD:197617 25/39 (64%)
GakNP_112292.1 STKc_GAK 39..320 CDD:270938 149/281 (53%)
S_TKc 41..311 CDD:214567 145/270 (54%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 332..354 2/21 (10%)
PTEN_C2 568..706 CDD:287393 47/137 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 747..856 12/111 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1044..1141 26/99 (26%)
DnaJ <1253..1298 CDD:99751 28/44 (64%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166349190
Domainoid 1 1.000 277 1.000 Domainoid score I1665
eggNOG 1 0.900 - - E1_KOG0431
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H3846
Inparanoid 1 1.050 527 1.000 Inparanoid score I1190
OMA 1 1.010 - - QHG45626
OrthoDB 1 1.010 - - D296562at33208
OrthoFinder 1 1.000 - - FOG0001565
OrthoInspector 1 1.000 - - otm46271
orthoMCL 1 0.900 - - OOG6_104372
Panther 1 1.100 - - LDO PTHR23172
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X2131
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.770

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