DRSC/TRiP Functional Genomics Resources

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Protein Alignment aux and tns2a

DIOPT Version :10

Sequence 1:NP_649438.1 Gene:aux / 40527 FlyBaseID:FBgn0037218 Length:1165 Species:Drosophila melanogaster
Sequence 2:XP_021325579.2 Gene:tns2a / 799109 ZFINID:ZDB-GENE-090312-163 Length:1616 Species:Danio rerio


Alignment Length:989 Identity:192/989 - (19%)
Similarity:317/989 - (32%) Gaps:355/989 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   351 KSSAYSEVYTEPLSAAIP---------SSYNGHGSLLSSLRGGAGTLLKNIKDTSTKVMQTMQQS 406
            |::.:.:...:..:|.||         :|.:.|...|.|.:....|..:|....|..|.:.|.:.
Zfish    76 KTATHKKCEAKINTACIPAQPSELRRGTSSSRHIQHLGSTKSLTYTKQRNTLPRSFSVDRVMDRV 140

  Fly   407 LARN-DLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTE--PR 468
            :.|: |.|:::||.||:.:..|....|..|:. |:.:|...|:|:. ..|..:.|..:|..  .|
Zfish   141 MERHYDFDLTYITERIISVFFPPLLEEQRYRL-NLREVAAMLKSKH-QDKFLLLNLSERRHDITR 203

  Fly   469 LPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICAL 533
            |.|.|..      :|.|..|:|.|..:..:...|.|:||:||:.||::....:.|.| ..:|.|.
Zfish   204 LNPKVHD------FGWPDMHSPPLDKICAMCKAMENWLNSDPQHVVVLHCKGNKGKT-GVIIAAY 261

  Fly   534 LMYADLLREPEDAVQVFAVKRH-----TINLRPSEFRYLYYFGDIL------RPTPLLPHYKNTT 587
            :.|:.:....:.|:...|:::.     ..:|:||:.||:.|||.:|      ..:||..|     
Zfish   262 MHYSKISAGADQALSTLAMRKFCEDKVASSLQPSQNRYIQYFGGLLSGSIKMNSSPLFLH----- 321

  Fly   588 LVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLST----LQDYEKMRLYQAGPGKIVLPINLTAC 648
              .:....:|.. :..||...::::|.:..|:.::    ||.....||.      |.:...|...
Zfish   322 --QVLIPTIPNF-QEDDGFFPFLKIYQSMQLVYTSGIYDLQGSASRRLI------ITIEPALLLK 377

  Fly   649 GDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDL-------PD------- 699
            ||:.|..:|.|  :...:...:.:.||:|..:...:  :.|...:||:.       ||       
Zfish   378 GDIMVKCYHRR--VESAERDSVFRLQFHTCTVHAAQ--LWFGKGELDEACSDDKFPPDAIVEFVF 438

  Fly   700 ---PEQVTPRFCVSLSLAVT-----------------------DSESPPSH-KPP---WMPAKPK 734
               ||::..|.......||:                       ||....:| :.|   .:.|:.|
Zfish   439 SSGPEKIKGRVSQRNDPAVSVDYNTNDPVVRWDSYENFNQRHQDSLEDIAHTRGPVDGSLYAQVK 503

  Fly   735 RSPAALFSSDLEYAEMLDNFVTKPSTRSSPPPGARKSDRVSSPLVLPDVTETAHEL--PSPMPEP 797
            :..||...|.|            |||..||   ||.|:...|.| |...|::.|..  |..:.||
Zfish   504 KRRAAAGCSSL------------PSTNGSP---ARSSEERPSQL-LSVSTDSGHSSVPPDRLDEP 552

  Fly   798 SPP-----------------IDLLNLNQQPSDVPAADPLTSAKPSTDASFDL------------- 832
            :.|                 |:...|..:..:....|...|..|....|..|             
Zfish   553 TRPAPPTQQEREELERLLGGIEGDGLRDRDRETAILDDGDSLPPERTGSLRLGRSCSCRVGYRSQ 617

  Fly   833 ----------------------------LGAFGDDDSTGIG-----SAPIPDILPPPPL----QQ 860
                                        .||.....|:.||     |......||||.|    ||
Zfish   618 GCAEPGCNGFHHLPNGHCLDRPTTTNGHTGALSPGMSSVIGLCQHHSTHPHQSLPPPDLLWDRQQ 682

  Fly   861 ---------------------PQPKINNDPFD--------------------------------- 871
                                 |..:||:.|..                                 
Zfish   683 GPQHYLHRTCSEGPSRHLYPYPSQEINSHPHSLSPRLLCRPDEYISYPHHHHNHSHHPKPSGPYH 747

  Fly   872 ----IFGSVDQG----------------------GV----------------------------- 881
                |.|.|..|                      |:                             
Zfish   748 DVMMIDGLVTPGCPCRDCALRREEFHTLRLDREDGIHWEREAELHRDNGLRRTREADMQRGAEIW 812

  Fly   882 ---PSMK---------------------------------PSGFPPFVGSLPTFVAQPAATTNPS 910
               |.::                                 .|.:.|....||.|...|....:|:
Zfish   813 EREPGLRRGREMSLHWDRDRDAELQWEREREAEYWHRRATVSPYGPHGHELPAFNFDPLPAGHPA 877

  Fly   911 PTHPARASADPFANIADLATGLNLNFNRSTLSGKSPVNTSPQPTQFSSPTHKPSPS-SQPQATFM 974
            ...|:|:.:.         ..|:|.::.|:...::|..|.|     .|| ::|||| |:..|:..
Zfish   878 YPEPSRSHSH---------AHLDLKYSSSSSGYQTPHQTCP-----CSP-YQPSPSESRGYASGY 927

  Fly   975 HTPPTPQTLPSTSSIRTPTQPQAVPAQSRPDYSRLHFDSQKAAQQPGTGGSKNSDIFADILGQQG 1039
            .:..|....|.::|...|....:.|.:::.|....||.|......||          ||.:|.:.
Zfish   928 QSESTSPLPPPSASCPGPVHHASGPTENQTDPHSQHFTSDSNTDCPG----------ADSIGWRN 982

  Fly  1040 Y-SFGSKMNQCPRS 1052
            : :.||.....|.:
Zfish   983 HITHGSLRRMHPHA 996

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
auxNP_649438.1 Protein Kinases, catalytic domain 49..326 CDD:473864
PTP_auxilin-like 404..573 CDD:350361 49/176 (28%)
PTEN_C2 581..711 CDD:463081 28/150 (19%)
PHA03247 <698..1037 CDD:223021 100/590 (17%)
Herpes_BLLF1 <882..>999 CDD:282904 28/150 (19%)
DnaJ <1110..1150 CDD:99751
tns2aXP_021325579.2 None
Blue background indicates that the domain is not in the aligned region.

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