DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and dnajc6

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_021332834.1	Gene:	dnajc6 / 796345	ZFINID:	ZDB-GENE-080104-2	Length:	979	Species:	Danio rerio

Alignment Length:	952	Identity:	300/952 - (31%)
Similarity:	440/952 - (46%)	Gaps:	178/952 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   349 PLKSSAYSEVYTE-PLSAAIPSSYNGHGSLLSSLRGGAGTLLKN--------IKDTSTKVMQTMQ 404
            |.:...||.:.:. |.|..:..:|.  |.||..::||||....|        |||||||||..:
Zfish    54 PARQDDYSTMDSSGPPSPDMDGNYG--GGLLDMVKGGAGKFFSNIKDNLKDTIKDTSTKVMNQV- 115

  Fly   405 QSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRL 469
            .:..:.:|||::|||||:||..|::..|..|: |:.||:|..|:||.. ...:::|..||.....
Zfish   116 ATYTKGELDIAYITSRIIVMSYPAETVEMGYR-NHTEDIRSFLDSRHA-DHYTVFNLSQRNYRGA 178

  Fly   470 PPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALL 534
            ....|..|.    ..|...||:|..||.|..:|||:|..:||:|.::...| |...:..::||:.
Zfish   179 KFSNRVSEC----NWPSRQAPSLHNLFAVCKNMYNWLKQNPKNVCVITCSD-GRAPSGVLVCAMF 238

  Fly   535 MYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKNTTLVSLSCQPVPRM 599
            .:..|...|..|:|:.:.||....|.||..||:.|...::...|.:||.|...:.:::..|||..
Zfish   239 CFCHLFANPVPAMQLLSAKRPGSGLWPSHRRYIGYVCSLVSEKPTVPHSKPLVIKTVTISPVPCF 303

  Fly   600 TKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVR 664
            .|.|.|||.:.:|......:.||.|:||:||.::...||:|.|:.::|.|||.:.::|.|...::
Zfish   304 NKQRSGCRPFCDVLIGETKIFSTAQEYERMREHRIQEGKVVFPVGVSAQGDVVISVYHMRSHALQ 368

  Fly   665 PQ--GLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKPP 727
            .:  ..:|.|.||:||||....|::.|...:||....||:....|.|.:.:.|..:|......||
Zfish   369 AKVTNTQIFQIQFHTGFIAPGSTVLKFMKTELDACDSPEKYPQLFHVLIDIEVESTEKQKDLTPP 433

  Fly   728 W--MPAKPKRSPAALFSSDLEYAEML---DNF----VTKPSTRSSPPPGARKSDRVSSP-----L 778
            |  .|.| ..||..|||...|:.:.|   |..    :..|:...|...|....:..|.|     |
Zfish   434 WEQFPTK-DLSPNVLFSCHQEHQDALAIADEMEGLDLEDPAQGHSSCGGRVGPNEESEPSDDEML 497

  Fly   779 VLPDVTETAHELPS-----PMPE---PSPP----IDLLNLNQQPSDVPAADPLTSAKPSTDASFD 831
            .|......|....|     |.|:   |.||    :|||.|:...:.:|.:.|   ..|:.:.:.|
Zfish   498 SLSSQQSNASNEKSKAAKRPEPQAAAPPPPAAEEVDLLGLDGDAAKIPPSSP---QPPANNTTTD 559

  Fly   832 LLGAFGDDDSTGIGSAPIPDILPPPPLQQ-------------PQPKINNDPFDIFGSVDQGGVPS 883
            |||..       .|:.|.|.....|...|             |.|:..| .||.|||   |..|:
Zfish   560 LLGDL-------FGAPPTPQPASCPGSAQSTPRRSAQSSSPGPSPRSGN-TFDPFGS---GPAPA 613

  Fly   884 MKPSGF-------------PPFV----------------------GSLPTFVAQ----------- 902
            .||..|             .||:                      .|.||...|
Zfish   614 PKPQDFMGAFLGPGNMGQPDPFLHAARSPSPTMQNMGMGRSSPVPPSTPTVNIQQQNSTGAWEWN 678

  Fly   903 -PA------------ATTNP------SPTHPARASA-DPFANIADLATGLNLNFNRSTLSGKSPV 947
             ||            |:|:|      :|||..:.:. ||||::.:|..||.     ...||.|..
Zfish   679 KPAAAGGGFGMGSKSASTSPTSSAHGTPTHQTKPNTLDPFADLGNLGAGLG-----GGGSGFSSK 738

  Fly   948 NTSPQPTQFSSP----THKPSPSSQPQATFMHTPPT----------PQTLPSTSSIRTPTQPQAV 998
            .|:|..|..:.|    ..:|:||.|..|:....|.|          .|..|......|...|.::
Zfish   739 PTTPTGTGGAFPPMGSPQRPAPSPQHTASGGWHPNTGFPSWQAGGGAQWQPQAQGTPTKAPPASM 803

  Fly   999 P---AQSRPDYSRLHFDSQKAAQQPGTGGSKN----------SDI-FADILGQQGYSFGSKMNQC 1049
            |   .|:||:|: :.|.:...| .||..|.|.          ||. |.|:|..||:: |.|..:.
Zfish   804 PHTSPQNRPNYN-VSFSAMSGA-SPGAAGPKAQPNMGTRPKVSDANFDDLLSGQGFA-GGKEKKG 865

  Fly  1050 PRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLWD-NAKWQRCEMSTMVTPTE 1113
            |::|.|||||::.|:|||:|::|::|.:||:.||||||.:||||||: ..:|:...|:.:|||.:
Zfish   866 PKTIAEMRKEEMAKEMDPEKLKILDWIEGKERNIRALLSTMHTVLWEGETRWKPVGMADLVTPEQ 930

  Fly  1114 VKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNAWTDFEN 1155
            |||.||:|.|.|||||..|...|:.||:||||||:||::||:
Zfish   931 VKKVYRKAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFES 972

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	45/131 (34%)
		DnaJ	<1110..1150	CDD:197617	24/39 (62%)
dnajc6	XP_021332834.1	PTEN_C2	285..420	CDD:313607	45/134 (34%)
		Atrophin-1	<538..842	CDD:331285	75/324 (23%)
		DnaJ	<927..968	CDD:99751	25/40 (63%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	129	1.000	Domainoid score	I5217
eggNOG	1	0.900	-	-		E1_KOG0431
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	517	1.000	Inparanoid score	I1247
OMA	1	1.010	-	-		QHG45626
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	1	1.000	-	-		FOG0001565
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_104372
Panther	1	1.100	-	-	O	PTHR23172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2131
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	11	10.880