DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and Dnajc6

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_001158055.1	Gene:	Dnajc6 / 72685	MGIID:	1919935	Length:	968	Species:	Mus musculus

Alignment Length:	960	Identity:	301/960 - (31%)
Similarity:	442/960 - (46%)	Gaps:	197/960 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 SPLKSSAYSEVYTEPLSAAIPS---SYNGHGSLLSSLRGGAGTLLKN--------IKDTSTKVMQ 401
            ||.:...:....|:...|:.|.   ||.  |.|...::||||.|..|        :||||::|:|
Mouse    47 SPARQPPHRASTTDSSGASSPDMEPSYG--GGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQ 109

  Fly   402 TMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTE 466
            :: .|..:.|||.:::||||:||..|.|..:..:: |.::|:|..|:||.: ...::||..
Mouse   110 SV-SSYTKGDLDFTYVTSRIIVMSFPVDSVDIGFR-NQVDDIRSFLDSRHL-DHYTVYNLS---- 167

  Fly   467 PRLPPPVRTVEAGS-VYGC--PQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAAT 528
               |...||.:..| |..|  |...||:|..||.|..:|||:|..:||:|.:|...| |...::.
Mouse   168 ---PKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLD-GRAASSI 228

  Fly   529 VICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKNTTLVSLSC 593
            ::.|:.::.:|...|..||::...||..|.|.||..|||.|..|:|...|..||:|..|:.:::.
Mouse   229 LVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKAITV 293

  Fly   594 QPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHA 658
            .|||...|.|:|||.|.:|......:.||..|:|:|:.|:...|||.:|:|:|..|||.|.::|.
Mouse   294 SPVPFFNKQRNGCRPYCDVLIGETKIYSTCTDFERMKEYRVQDGKIFIPLNITVQGDVIVSMYHL 358

  Fly   659 RKGM-----VRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDS 718
            |..:     .:....:|.|.||::||||...|::.||..:||....||:....|.|:|.:.|...
Mouse   359 RSTIGSRLQAKVTNTQIFQLQFHSGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVTLDIEVQPQ 423

  Fly   719 ESPPSHKPPWMPAKPKR-SPAALFSSDLEYAEML------------------------------- 751
            :......|||.....|. :|:.||||..|:.:.|
Mouse   424 DKVIDLTPPWEHYCTKDVNPSILFSSQQEHQDTLALGGQAPADLPPDHPRNLGQGGFFASLCWQD 488

  Fly   752 ----------DN--FVTKPS--------TRSSP--------PPGARKSDRVSSPLVLPDVTETAH 788
                      |:  .|.:.|        |.|||        |.||:|..:.......|
Mouse   489 QKSEKSRCEEDHAALVNQESEQSDDELLTLSSPHGNAEGDKPHGAKKPGKKQQEPAAP------- 546

  Fly   789 ELPSPMPEPSPPIDLLNLNQQPSDVPAADPLTSAKPS-TDASFDLLGAFGDDDSTGIGSAPIPDI 852
                |.||   .:|||.|  :.|||.......:|.|| ::...||.|..|.......|.|.:.|:
Mouse   547 ----PPPE---EVDLLGL--EGSDVSTNFSSLAAPPSNSELLSDLFGGVGATGPAQAGQAGVEDV 602

  Fly   853 LPP--PPLQQPQPK-----------------INNDPFDIFGSVDQGGVPSMKPSGFPPFVGSLPT 898
            ..|  |...|..|:                 ...|||         |.|:.     ||....|.:
Mouse   603 FHPSGPVSAQSTPRRTATSASASPTLRVGEGATFDPF---------GAPAK-----PPGQDLLGS 653

  Fly   899 FVAQPAATTNP------SPTHPARASADPFANI-ADLATGLNLNFNRSTLS-GKSPVNTSPQPTQ 955
            |:...:|:::|      ||:....||:.|..|| .|:|.|.:.:....... |.....|||..:.
Mouse   654 FLNTSSASSDPFLQPTRSPSPTVHASSTPAVNIQPDIAGGWDWHTKPGGFGMGSKSAATSPTGSS 718

  Fly   956 FSSPTHKPSPSS-QP--------QATFMHTPPTPQTL-----PSTSSIRTPTQP----------- 995
            ..:|||:..|.: .|        .::|...|.||..|     |.:|..:...||
Mouse   719 HGTPTHQSKPQTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAGY 783

  Fly   996 -----QAVP--------AQSRPDYSRLHFDSQKAAQQPGTGGSKNSD------IFADILGQQGYS 1041
                 |:.|        .|:||:|: :.|.:..|.|.....||.|.:      .|.|:|..||::
Mouse   784 NWQQTQSKPQSSMPHSSPQNRPNYN-VSFSAMPAGQSERGKGSTNLEGKQKAADFEDLLSSQGFN 847

  Fly  1042 FGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLW-DNAKWQRCEM 1105
             ..|..:.||:|.|||||::.|:|||:|::|:||.:||:.||||||.:|||||| ...||:...|
Mouse   848 -AHKDKKGPRTIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGM 911

  Fly  1106 STMVTPTEVKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNAWTDFEN 1155
            :.:|||.:|||.||||.|.|||||..|...|:.||:||||||:||::|||
Mouse   912 ADLVTPEQVKKVYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFEN 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	49/134 (37%)
		DnaJ	<1110..1150	CDD:197617	25/39 (64%)
Dnajc6	NP_001158055.1	PTEN_C2	281..419	CDD:287393	50/137 (36%)
Dnajc6	NP_001158055.1	DnaJ	<916..961	CDD:99751	28/44 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	124	1.000	Domainoid score	I5502
eggNOG	1	0.900	-	-		E1_KOG0431
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	525	1.000	Inparanoid score	I1232
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG45626
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	1	1.000	-	-		FOG0001565
OrthoInspector	1	1.000	-	-		otm44179
orthoMCL	1	0.900	-	-		OOG6_104372
Panther	1	1.100	-	-	O	PTHR23172
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2131
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.840