Protein Alignment aux and aak1a

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: XP_005167369.1
• Gene: aak1a / 568999
• ZFINID: ZDB-GENE-081105-101
• Length: 1052
• Species: Danio rerio
• Alignment Length: 1158
• Identity: 255/1158 - (22%)
• Similarity: 403/1158 - (34%)
• Gaps: 339/1158 - (29%)

  Fly    14 SSSEVNGAAGNGAPEALGGRLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEYAL 78
            |.:...|.||:||           |:|:|..:..:::.::..:||||:|.|::.:..| |...||
Zfish    18 SGAGAGGGAGSGA-----------FIGRVFSIGRYQVTVEETVAEGGFAIVFLVRTHQ-GVRCAL 70

  Fly    79 KRLI---GADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLV 140
            ||:.   ..|:|....   ||.|.:.|.|::|||.|:.||.||..:....:.|:|.:.|:||.:|
Zfish    71 KRMYVNNEHDLQVCKM---EIQIMRDLVGNKNIVGFLDSSITAVGSGDVWEVLILMDFCRGGQVV 132

  Fly   141 DCFRTN-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSAST 204
            :..... ...|:.:.||:||.....|||.||...|||.|||:|:||.|:.:.....|||||||..
Zfish   133 NLMNQRLQTGFSESEVLQIFCDTCEAVARLHQCKPPIIHRDLKVENILLHDRGHYVLCDFGSAIN 197

  Fly   205 EVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHP 269
            ...:|..|..|    ::|:::...||..||:|||::.:....|..|.|||||||:||.|||...|
Zfish   198 RSQNPQTEGVA----VVEEEIKKYTTLSYRAPEMVNLYGGMVITTKADIWALGCLLYKLCYFTLP 258

  Fly   270 YEDGGKLRIINANYMLPPDPQY----QCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSL 330
            :.: .::.|.:.::.:|.:.:|    .|   :||..|:.:|..|.||..|          ..::.
Zfish   259 FGE-SQVAICDGSFTIPDNSRYSHDMHC---LIRYMLEPDPDMRPDIFQV----------SYFAF 309

  Fly   331 KGPLDLHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDT 395
            |  |.....|:::              |:..|:...:|.......::....:..| .|...:..|
Zfish   310 K--LSRRDCPVQN--------------VHNSPIPTKLPEPIRASEAVAKKSQNKA-RLTDPVPTT 357

  Fly   396 STKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVP------- 453
            .|.:....:....:    ...||..:.:.|                    :|..|..|
Zfish   358 ETSIAPRQRPKAGQ----AQPITGILPIQP--------------------ALTPRKRPSAPPGPS 398

  Fly   454 QKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQT 518
            |.:|:....|       |||...:|..   .|....|....|| |......|..|..:.....||
Zfish   399 QPISVNMASQ-------PPVAQQQATP---SPPQTTPQHAQLF-VQQQNTAFFTAQQQQNHSTQT 452

  Fly   519 GDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHY 583
                                         |:.|....| ..:|..          ..|.|.:.|.
Zfish   453 -----------------------------QMPAASPST-QSKPKN----------RAPPPPMHHP 477

  Fly   584 KNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTAC 648
            :...|.:||                            :|.|...| .:..|.|.:....::
Zfish   478 QPDRLTTLS----------------------------ATTQTKPK-AMAPAPPAESSHSVD---- 509

  Fly   649 GDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSL 713
            |:.:|......|.|..                |.|.:..:.|      ||.|.        |.|.
Zfish   510 GEASVSAQPKTKAMAP----------------PPPASHASTT------LPPPN--------STSA 544

  Fly   714 AVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTRSSPPPGARK---SDRVS 775
            |.|.|...|.          :||.|.  |..:.....|    |.||:..:.|.|..:   ||...
Zfish   545 ASTYSGGEPE----------QRSAAG--SRGVHKVGSL----TPPSSPKAAPKGGHRRILSDVTH 593

  Fly   776 SPLVLPDVTETAHELPSPMPEPSPPIDLLNLNQQPSDVPAADPLTSAK---PSTDASFDLLGA-- 835
            |.:....|:::...|.:...|.|     ||.::..|..|:..|.:|.:   ...|||....||
Zfish   594 STIFGVPVSKSTQLLQAAAAEAS-----LNKSKSASTTPSGSPCSSQQSVYQPADASGHSAGATG 653

  Fly   836 ----FGDDDSTGI-----------------------------------------GSAPIPDILPP 855
                ||||:.:.:                                         |.|.:..::|.
Zfish   654 SWNPFGDDNFSKLTAEELLNKDFAKLDAKTAERSCPENLISGLQSVSSNKGFLQGGAGMDSLIPG 718

  Fly   856 -PPLQQ-------PQPKINNDPFDIFGSV----DQGGVPSMKPSGFPPFVGSLPTFVAQPAATTN 908
             .|||.       |:..:..|.. :.||:    ..||:....||..|  |.|:..|.|     .:
Zfish   719 LDPLQTDLKSAALPECLVGRDSL-LDGSLLSHPSAGGLLLSSPSSLP--VPSVDQFTA-----LS 775

  Fly   909 PSPTHPARASADPFANIADLATG-------------LNLNFNRSTLSGKSP----VNTSPQPTQ- 955
            ..|:|.|.....|.:......||             ||...:.....|||.    .:....||:
Zfish   776 SGPSHQASDQNHPLSGFQSSETGDQSSDNQFDPIPVLNSKSSSQEAEGKSDGYGIADDDENPTEE 840

  Fly   956 ---FSSPTHKPSPSSQPQATFMHTPPTPQTLPSTSS----IRTPTQPQAVPAQSR----PDYSRL 1009
               .||.........:.|.:...||    :|..:.|    ..:..:.:..||.||    ...|.:
Zfish   841 DFPHSSDEDDAEKGGRSQVSGDETP----SLDCSGSRPLLQDSDDEDEQSPASSRNLRMSSASEV 901

  Fly  1010 HFDSQKAAQQPGTGGSKNSDIFADILGQQGYSFGSKMNQCPRSINEMRKEDLF 1062
            ..::|...|...:|...:.|:|:    :..:..|..::.     |...:.|:|
Zfish   902 ASENQSEIQAQRSGADPSVDVFS----KAPFRIGQNLDD-----NNSNEGDVF 945

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	98/284 (35%)
		PTP_auxilin-like	404..573	CDD:350361	26/175 (15%)
		PTEN_C2	581..711	CDD:463081	19/129 (15%)
		PHA03247	<698..1037	CDD:223021	89/432 (21%)
		Herpes_BLLF1	<882..>999	CDD:282904	27/141 (19%)
		DnaJ	<1110..1150	CDD:99751
aak1a	XP_005167369.1	STKc_NAK_like	39..312	CDD:270939	99/296 (33%)
		PHA03247	<317..642	CDD:223021	84/498 (17%)