DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and tns1a

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_009300586.1	Gene:	tns1a / 565181	ZFINID:	ZDB-GENE-120215-32	Length:	1688	Species:	Danio rerio

Alignment Length:	1074	Identity:	205/1074 - (19%)
Similarity:	331/1074 - (30%)	Gaps:	428/1074 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   389 LKNIKDTSTKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVP 453
            ||........:|||::::   |::|:.:||.||:.:..|....|:.|.. ::.:|...|.|:. .
Zfish   111 LKRRPSRRLSLMQTLEEN---NEVDLLYITERIIALSFPGGTEENKYSV-HLREVTSMLRSKH-Q 170

  Fly   454 QKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQT 518
            |...:.|..:|.........|.::    :|.|..|||.|..:.::...|..:|||||.:||::..
Zfish   171 QHYLMLNLSERRHDITKQNPRVLD----FGWPDHHAPALDKICSICKAMDTWLNADPHNVVVLHN 231

  Fly   519 GDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINL-----RPSEFRYLYYFGDIL---- 574
            ..:.|.| ..|:.|.:.|:::....:.|:..||:||...:.     :||:.||:.||..:|
Zfish   232 KGNWGRT-GVVVGAYMHYSNISASADQALDRFAMKRFYEDKAMPVGQPSQRRYVQYFAGLLSGHI 295

  Fly   575 --RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPG 637
              ...||..|:       :....:|.. ::..|||.::::|       ..:|......:|.....
Zfish   296 KINNKPLFLHH-------VIMHGIPNF-ESIGGCRPFLKIY-------QAMQPVYTSGIYNVKGD 345

  Fly   638 K-----IVLPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDD- 696
            .     |.:...|...||:.:..:|.|  ...|....|.:.||:|..:  ....:.||..||||
Zfish   346 SHTSICITIEPGLLLKGDILLKCYHKR--YQNPSRDVIFRVQFHTCAL--HNLALVFTKNDLDDT 406

  Fly   697 ------LP-----------DPEQVT------------------------------PRFCVSLSLA 714
                  .|           |||::.                              .|.|..:::.
Zfish   407 FKADERFPEYGKVEFIFSFDPEKIKGLDHLQNGPSVSVDYNTQDPLIRWDSYENFNRRCEDVNVD 471

  Fly   715 VTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLD-NFVTKPSTRSS-----PPPGARKSDR 773
            ...::.|                             :| |...:...::|     |..||..:||
Zfish   472 AAHTQGP-----------------------------IDGNLYARVQKKNSLEGIVPANGAYSTDR 507

  Fly   774 VSSPLVLPDVTETAHELPSPMPEPSPPIDLLNLNQQPSDVPAAD--------------------- 817
            |      |.|.|  |.||.|:           .|.|   :||||
Zfish   508 V------PPVAE--HALPLPV-----------ANHQ---LPAADHALSVSSDSGNSTASVKTDRT 550

  Fly   818 -----------PLTSAKPST-----------------------------------------DASF 830
                       |::.|.|.|                                         .|..
Zfish   551 DDAQQSLSSSGPVSQAPPGTVISPCENRELEQLLSGSEGPPHQSFLSFANTSPGVGVRHLVPAQV 615

  Fly   831 DLLGAFGDDDSTGIGSAPIPDILPPP--------------------------------------- 856
            .:.|..|.:..|||    |.|.||..
Zfish   616 HVNGQAGAERETGI----IDDELPESQVGDNSAGSLGTLSSFEGQDTPADSKTVTECTVVEVEGH 676

  Fly   857 -------------PLQQ--------------------------------------PQ-PKIN--- 866
                         |:.|                                      || |:.|
Zfish   677 CGTFLERRSKKEMPVHQLRGSSSAHGLIDYSGQNEGMYRSQSYGGMMLDGGHRYLPQAPERNTSS 741

  Fly   867 -----------------NDPFDIFGSVDQGGVPSMKPSGFPPFVGSLPTFVAQPAATTNP----- 909
                             :|||  |||  .|.:|.....|     |.....|.|.....|.
Zfish   742 REAVQRGLSAWHQYGLVDDPF--FGS--NGALPRFSTRG-----GGSQQDVEQSIDALNMLMLDL 797

  Fly   910 SPTH---PARASADPFANIADLATGLNLNFNRS---------TLSGKSPVNTSP---QPTQFSSP 959
            .|:|   |...||.|..||:...........|.         :::|..|:::|.   |.:|.|||
Zfish   798 EPSHTPVPKSQSAPPGENISAFHPPFGQTIARPSYQADQAIYSVTGGPPLSSSASFGQSSQRSSP 862

  Fly   960 THKPSPSSQPQATFMHTPPTPQTLPST-----------SSIRTPTQPQAVPAQSRPDYSRLHFDS 1013
            .:..:|:|..|..:..||.||||..|.           .|:.||:....:|:..:|.|
Zfish   863 AYPITPTSDHQRGYPQTPQTPQTPYSPIYQQDPYSIRGGSVTTPSPTLTLPSPIKPQY------- 920

  Fly  1014 QKAAQQPGTGGSKNSDIFADILG-QQGYSFGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTD 1077
                ..||:..|.:.|:.....| |:.||..|         :.:....|.|:.:||       ::
Zfish   921 ----VYPGSEVSYSPDLQGTFPGPQKSYSASS---------SPLPPVTLAKEPEPK-------SE 965

  Fly  1078 GKKNNIRALLCSMHTVLWDNAKWQRCEM------------------STMVTPTEVKKAYRRACLA 1124
            .:..|:..|:.  |.|...||:.:....                  |..|||.|.....||.  .
Zfish   966 EEMLNLEGLVA--HRVAEYNARIRGISKSMSFQSEHHRSYSFSGSHSRTVTPDEAMPTVRRR--T 1026

  Fly  1125 VHPDKHNGTENEEIAKLIFMELNNAWTDFENDAT 1158
            ....::..::::..|.::...|....::|.|..|
Zfish  1027 TSESQYLSSQHDSAAHVVRSPLKPVSSEFANTIT 1060

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	31/182 (17%)
		DnaJ	<1110..1150	CDD:197617	7/39 (18%)
tns1a	XP_009300586.1	C1	<55..88	CDD:197519
		PTPc_motif	188..>257	CDD:214649	20/73 (27%)
		PTEN_C2	297..424	CDD:287393	28/145 (19%)
		SH2_Tensin_like	1404..1519	CDD:198181
		PTB_tensin	1553..1683	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810