DRSC/TRiP Functional Genomics Resources

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Protein Alignment aux and BMP2K

DIOPT Version :9

Sequence 1:NP_649438.1 Gene:aux / 40527 FlyBaseID:FBgn0037218 Length:1165 Species:Drosophila melanogaster
Sequence 2:NP_942595.1 Gene:BMP2K / 55589 HGNCID:18041 Length:1161 Species:Homo sapiens


Alignment Length:1182 Identity:248/1182 - (20%)
Similarity:418/1182 - (35%) Gaps:327/1182 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 GAAGNGAPEALGGR---LDNDFVG-QVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEYALKR 80
            ||||.||..|..|.   .....|| :|..|..|::.::..:||||::.|::.: ...|...||||
Human    17 GAAGGGAGGAGAGAGCGSGGSSVGVRVFAVGRHQVTLEESLAEGGFSTVFLVR-THGGIRCALKR 80

  Fly    81 LIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCFRT 145
            :...:|........||.|.|:||||:|||.::..:..:.|..:. :.|:|.|.|:.|.:|:....
Human    81 MYVNNMPDLNVCKREITIMKELSGHKNIVGYLDCAVNSISDNVW-EVLILMEYCRAGQVVNQMNK 144

  Fly   146 N-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSP 209
            . ...|....||:||.....|||.||....||.|||:|:||.|:.:.....|||||||:.:.|:|
Human   145 KLQTGFTEPEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLNDGGNYVLCDFGSATNKFLNP 209

  Fly   210 TFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGG 274
                ..:..:::|:::...||..||:|||::.:...||..|.|||||||:||.||:...|:.: .
Human   210 ----QKDGVNVVEEEIKKYTTLSYRAPEMINLYGGKPITTKADIWALGCLLYKLCFFTLPFGE-S 269

  Fly   275 KLRIINANYMLPPDPQY----QCFSDIIRGCLKVNPFERLDITMV-------LEGLAALAETHNW 328
            ::.|.:.|:.:|.:.:|    .|   :||..|:.:|..|.||..|       .:....::..:|.
Human   270 QVAICDGNFTIPDNSRYSRNIHC---LIRFMLEPDPEHRPDIFQVSYFAFKFAKKDCPVSNINNS 331

  Fly   329 SLK---------------------------GPLDLHIMPIE---------SLPAESPLKSSAYSE 357
            |:.                           ||.:..|.|.:         :.|:...::|||   
Human   332 SIPSALPEPMTASEAAARKSQIKARITDTIGPTETSIAPRQRPKANSATTATPSVLTIQSSA--- 393

  Fly   358 VYTEPLSAAIPSSYNGHGSLLSSLRGGAG--TLLKNIKDTSTKVMQTMQQSLARNDLDISHITSR 420
               .|:....|..:..|.. ..:||.|.|  .||.............:.|.|.:.|..:.     
Human   394 ---TPVKVLAPGEFGNHRP-KGALRPGNGPEILLGQGPPQQPPQQHRVLQQLQQGDWRLQ----- 449

  Fly   421 ILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCP 485
                                   :|.|:.|...|:       |:.:.:.....:..:........
Human   450 -----------------------QLHLQHRHPHQQ-------QQQQQQQQQQQQQQQQQQQQQQQ 484

  Fly   486 QAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVF 550
            |.|..:........|.|..:.:|..:..::.|              ..||::  :.:|:      
Human   485 QQHHHHHHHHLLQDAYMQQYQHATQQQQMLQQ--------------QFLMHS--VYQPQ------ 527

  Fly   551 AVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKNTTL-VSLSCQPVPRMTKARDGCRIYMEVYC 614
                      ||..:|         || ::|.|:.... ..:..|..|...:|...         
Human   528 ----------PSASQY---------PT-MMPQYQQAFFQQQMLAQHQPSQQQASPE--------- 563

  Fly   615 NGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTA-CGDVTVVLFHARKGMVRPQGLKICQFQFNTG 678
                .|::.|::        .|..:....:|.| .|.:....:.|.:.:...:.:.....|.|..
Human   564 ----YLTSPQEF--------SPALVSYTSSLPAQVGTIMDSSYSANRSVADKEAIANFTNQKNIS 616

  Fly   679 FIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAV---------TDSESPPSHKPPWMP---- 730
            ..|:......|...:...|.:.|.:...|.:..|..:         .||.|.|.:.||..|    
Human   617 NPPDMSGWNPFGEDNFSKLTEEELLDREFDLLRSNRLEERASSDKNVDSLSAPHNHPPEDPFGSV 681

  Fly   731 -------AKPKRSPAALFSSDLEYAEMLDNFVTKPSTR--------------------------S 762
                   :..|::..:..:.:...|..:.|..|.|:::                          |
Human   682 PFISHSGSPEKKAEHSSINQENGTANPIKNGKTSPASKDQRTGKKTSVQGQVQKGNDESESDFES 746

  Fly   763 SPP-PGARKSDRVSSPLVL--------PDVTETAHELPSPMPEPSPPIDLLNLNQQPSDVPAADP 818
            .|| |.:.:.:......||        .|.||         ||        ||..:|..:.:.|.
Human   747 DPPSPKSSEEEEQDDEEVLQGEQGDFNDDDTE---------PE--------NLGHRPLLMDSEDE 794

  Fly   819 LTSAKPSTDASF--------DLLGAFGDDDSTG---------IGSAPI-PDILPPPPLQQPQPKI 865
            ....|.|:|:.:        |:...:.|...:|         :.||.: .|:....|.|:     
Human   795 EEEEKHSSDSDYEQAKAKYSDMSSVYRDRSGSGPTQDLNTILLTSAQLSSDVAVETPKQE----- 854

  Fly   866 NNDPFDIFGSVDQGGVPSMKPS-----------GFP---------------PF---VGSLPTFVA 901
                ||:||:|....|.:.:|.           .||               ||   |........
Human   855 ----FDVFGAVPFFAVRAQQPQQEKNEKNLPQHRFPAAGLEQEEFDVFTKAPFSKKVNVQECHAV 915

  Fly   902 QPAATTNPSPTHPARASADPFAN--IADLATGLNLNFNRSTLSGKSPVN--TSPQPTQFSSPTHK 962
            .|.|.|.|.  :|  .|.|.|.:  .....|..:.:.:...|.|..|.:  |..|..:....:.:
Human   916 GPEAHTIPG--YP--KSVDVFGSTPFQPFLTSTSKSESNEDLFGLVPFDEITGSQQQKVKQRSLQ 976

  Fly   963 PSPSSQPQATFMHTPPTPQTLPSTSSIR---TPTQPQAV--PAQSRPDYSRLHFDSQKAAQQPGT 1022
            ...|.|.:        |.|.:..::..|   |||..:..  |....|:.:|.|       ::.|.
Human   977 KLSSRQRR--------TKQDMSKSNGKRHHGTPTSTKKTLKPTYRTPERARRH-------KKVGR 1026

  Fly  1023 GGSKNSDIFADI 1034
            ..|::|:.|..|
Human  1027 RDSQSSNEFLTI 1038

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
auxNP_649438.1 PKc_like 49..326 CDD:304357 93/288 (32%)
S_TKc 51..317 CDD:214567 93/277 (34%)
PTEN_C2 581..711 CDD:287393 19/131 (15%)
DnaJ <1110..1150 CDD:197617
BMP2KNP_942595.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20 2/2 (100%)
STKc_NAK_like 47..320 CDD:270939 94/282 (33%)
S_TKc 52..311 CDD:214567 92/268 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 358..439 17/87 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 453..495 6/48 (13%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 610..630 4/19 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..832 33/193 (17%)
BMP2K_C 893..1161 CDD:291930 34/165 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 965..1035 16/84 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1137..1161
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D826336at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.920

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