DRSC/TRiP Functional Genomics Resources

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Protein Alignment aux and Pten

DIOPT Version :10

Sequence 1:NP_649438.1 Gene:aux / 40527 FlyBaseID:FBgn0037218 Length:1165 Species:Drosophila melanogaster
Sequence 2:NP_113794.1 Gene:Pten / 50557 RGDID:61995 Length:403 Species:Rattus norvegicus


Alignment Length:427 Identity:98/427 - (22%)
Similarity:163/427 - (38%) Gaps:109/427 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   403 MQQSLARN---------DLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSI 458
            :::.::||         |||:::|...|:.|..|::..|..|: |||:||...|:|:. .....|
  Rat     5 IKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYR-NNIDDVVRFLDSKH-KNHYKI 67

  Fly   459 YNF-GQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSG 522
            ||. .:|.........|..:    |.....:.|.|:.:.....|:..:|:.|...|..:......
  Rat    68 YNLCAERHYDTAKFNCRVAQ----YPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGK 128

  Fly   523 GCTAATVICALLMYADLLREPEDAVQVFAVKRH------TINLRPSEFRYLYYFGDIL------R 575
            |.| ..:|||.|::.....:.::|:..:...|.      ||   ||:.||:||:..:|      |
  Rat   129 GRT-GVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTI---PSQRRYVYYYSYLLKNHLDYR 189

  Fly   576 PTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPG--- 637
            |..||.|       .:..:.:|..:...          ||...::..|    |:::|.:..|   
  Rat   190 PVALLFH-------KMMFETIPMFSGGT----------CNPQFVVCQL----KVKIYSSNSGPTR 233

  Fly   638 ---KIV---LPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPE------------ 684
               |::   .|..|..|||:.|..||.:..|::..  |:..|..||.|||.||            
  Rat   234 REDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKD--KMFHFWVNTFFIPGPEETSEKVENGSLC 296

  Fly   685 -------------------TLITFTNQDLDDLPDPE---QVTPRFCVSLSLAVTDSESPPSHKPP 727
                               .::|.|..|||.....:   ..:|.|.|.|....|..|        
  Rat   297 DQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEE-------- 353

  Fly   728 WMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTRSSP 764
              |:.|:.|.:...:.|:...|. |::....:|.|.|
  Rat   354 --PSNPEASSSTSVTPDVSDNEP-DHYRYSDTTDSDP 387

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
auxNP_649438.1 Protein Kinases, catalytic domain 49..326 CDD:473864
PTP_auxilin-like 404..573 CDD:350361 46/184 (25%)
PTEN_C2 581..711 CDD:463081 35/172 (20%)
PHA03247 <698..1037 CDD:223021 15/70 (21%)
Herpes_BLLF1 <882..>999 CDD:282904
DnaJ <1110..1150 CDD:99751
PtenNP_113794.1 PTP_PTEN 24..181 CDD:350359 42/166 (25%)
PTEN_C2 188..349 CDD:463081 40/183 (22%)
Required for interaction with NOP53. /evidence=ECO:0000250|UniProtKB:P60484 338..348 4/9 (44%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 352..403 10/47 (21%)
PDZ domain-binding. /evidence=ECO:0000250|UniProtKB:O08586 401..403
Blue background indicates that the domain is not in the aligned region.

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