DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and Pten

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_113794.1	Gene:	Pten / 50557	RGDID:	61995	Length:	403	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	98/427 - (22%)
Similarity:	163/427 - (38%)	Gaps:	109/427 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   403 MQQSLARN---------DLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSI 458
            :::.::||         |||:::|...|:.|..|::..|..|: |||:||...|:|:. .....|
  Rat     5 IKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYR-NNIDDVVRFLDSKH-KNHYKI 67

  Fly   459 YNF-GQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSG 522
            ||. .:|.........|..:    |.....:.|.|:.:.....|:..:|:.|...|..:......
  Rat    68 YNLCAERHYDTAKFNCRVAQ----YPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGK 128

  Fly   523 GCTAATVICALLMYADLLREPEDAVQVFAVKRH------TINLRPSEFRYLYYFGDIL------R 575
            |.| ..:|||.|::.....:.::|:..:...|.      ||   ||:.||:||:..:|      |
  Rat   129 GRT-GVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTI---PSQRRYVYYYSYLLKNHLDYR 189

  Fly   576 PTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPG--- 637
            |..||.|       .:..:.:|..:...          ||...::..|    |:::|.:..|
  Rat   190 PVALLFH-------KMMFETIPMFSGGT----------CNPQFVVCQL----KVKIYSSNSGPTR 233

  Fly   638 ---KIV---LPINLTACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPE------------ 684
               |::   .|..|..|||:.|..||.:..|::..  |:..|..||.|||.||
  Rat   234 REDKLMYFEFPQPLPVCGDIKVEFFHKQNKMLKKD--KMFHFWVNTFFIPGPEETSEKVENGSLC 296

  Fly   685 -------------------TLITFTNQDLDDLPDPE---QVTPRFCVSLSLAVTDSESPPSHKPP 727
                               .::|.|..|||.....:   ..:|.|.|.|....|..|
  Rat   297 DQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEE-------- 353

  Fly   728 WMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTRSSP 764
              |:.|:.|.:...:.|:...|. |::....:|.|.|
  Rat   354 --PSNPEASSSTSVTPDVSDNEP-DHYRYSDTTDSDP 387

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	35/172 (20%)
		DnaJ	<1110..1150	CDD:197617
Pten	NP_113794.1	PTP_PTEN	24..181	CDD:350359	42/166 (25%)
Pten	NP_113794.1	PTEN_C2	188..349	CDD:402161	40/183 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810