Protein Alignment aux and bmp2k

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_001180469.1
• Gene: bmp2k / 494101
• ZFINID: ZDB-GENE-041212-72
• Length: 1081
• Species: Danio rerio
• Alignment Length: 1193
• Identity: 270/1193 - (22%)
• Similarity: 439/1193 - (36%)
• Gaps: 276/1193 - (23%)

  Fly    19 NGAAGNGAPEALGGRLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQTGTEYALKRLIG 83
            :|:.|.|:....|   .::::|:|..|..:::.::.:|||||::.|::|: ..:|...||||:..
Zfish    12 SGSLGGGSGSGTG---SSNYIGKVFAVGRYQVTVEELIAEGGFSMVFLAR-THSGVRCALKRMYV 72

  Fly    84 ADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCFRTN-N 147
            .::........||.|.|:||||:|||.::.|:..|....:. :.|:|.|.||.|.:|...... :
Zfish    73 NNVHDLNIFRREITIMKELSGHKNIVRYLDSTTNAVGDSVW-EVLILMEYCKAGQVVKQMNQRLH 136

  Fly   148 APFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFE 212
            ..|....||.||.....|||.||....||.|||:|:||.|:.:.....|||||||:.:||.|
Zfish   137 IGFTEAEVLNIFCDACEAVARLHQCKTPIIHRDLKVENILLNDQGNYVLCDFGSATHKVLLP--- 198

  Fly   213 WSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYEDGGKLR 277
             ..:..:.:||::...||..||:|||::.:....|..|.|||||||:||.||:...|:.: .::.
Zfish   199 -HKDGITAVEDEIKKYTTLSYRAPEMINLYQGKAITTKADIWALGCLLYKLCFFTLPFGE-SQVA 261

  Fly   278 IINANYMLPPDPQYQC-FSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPLDLHIMPI 341
            |.:..:.:|...::.. ...:||..|:.:..:|.||..|......||...            .|:
Zfish   262 ICDGTFAVPDGSKFSSKLHGLIRYMLEPDQEKRPDIYQVSYFAFRLAGKE------------CPV 314

  Fly   342 ESLPAESPLKSSAYSEVYTEPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDTSTKVMQTMQQS 406
            .:| ..|||.:|     ..||.:|   |......||..:      .:..::..|.|.:....:..
Zfish   315 PNL-FNSPLPTS-----LPEPFTA---SDIAAKKSLTKA------RITDSVGPTETSIAPRQRPK 364

  Fly   407 LARND---LDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPR 468
            .|.::   |..|....::.|.....:|.:|..:..|      |.:...|.|:|.
Zfish   365 AANSNVLPLSSSVTPVKMTVTTASGNGQQSAAQMPN------SSQQNRVLQQLQ----------- 412

  Fly   469 LPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSAD----MYNFLNADPKSVVIVQTGDSGGCTAATV 529
             |..:|..:........|.| .|:|....::|.    |..:..|..:|:.:.|
Zfish   413 -PGDLRLQQLHHQQQQQQQH-HNIQHQQQIAAQQLQYMQQYHQAMQQSLQMQQ------------ 463

  Fly   530 ICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKNTTLVSLSCQ 594
                  :..:|::.:   |...:::..|.....:.:..:|       |.|:..|:...:....|.
Zfish   464 ------HQHMLQQQQ---QQMMMQQQPIYQSQQQQQQAHY-------TALMQQYQQAFVQQQQCA 512

  Fly   595 PVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQ-AGPGKIVLPINLTACGDVTVVLFHA 658
            ||.::.                  .:|.|:....:..|. |||..:..|....:|....|.....
Zfish   513 PVHQVP------------------YISPLEFQTSVGSYNPAGPSPVETPFTNISCSRNPVSAVDV 559

  Fly   659 RKGMVRPQGLKICQFQFNTGFIPEPETLIT---------FTNQDLDDLPDPEQVTPRF------- 707
            ..                    |.|:|:..         |...:...|.:.|.:...|
Zfish   560 MS--------------------PPPQTVSNPPDMSSWNPFGEDNFSKLTEEELLNREFDLLRAKK 604

  Fly   708 ----CVSLSLAVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTR---SSPP 765
                .||:..:..|.:.|...  |.:|..|..|...|.::........:|.|..||..   ::||
Zfish   605 PVERSVSMEASSVDRQQPVLQ--PSLPEDPFGSVPFLANAAGAGVLTAENPVENPSVSVQDTTPP 667

  Fly   766 ------PGARKSDRVSSPLVLPDVTETAHELPSPMPEPSPPIDL---------------LNLNQQ 809
                  |..:.|...|.|....:.:::..|...|.|:.|...::               .||.|:
Zfish   668 LAKERKPAKKSSSTGSLPQKAREDSDSDFESDPPSPKSSEDEEVEEEEALNSEHEDTEPENLGQR 732

  Fly   810 PSDVPAADPLTSA--KPSTDASFDLLGAFGDDDSTGIGSAPIPDILP------PPPLQQPQPKIN 866
            |..:.:.|.:...  |.|:|:         |.||.....:.:|..:.      .||:........
Zfish   733 PLLMDSEDEIEEEEDKHSSDS---------DCDSRKAKLSEVPPAVESGASVITPPISPSASMTA 788

  Fly   867 NDPFDIFGSVDQGGVPSMKPSGFPPFVGSLPTFVAQPAATTNPSPTHPAR-ASADPFANIADLAT 930
            .:..|:||:|              |||||     .|...:::.....|.| ||.:......|:.|
Zfish   789 KNLVDVFGAV--------------PFVGS-----GQAPESSDIFAKAPFRQASQENALEETDVFT 834

  Fly   931 --GLNLNFNRSTLSGKSPVNTSPQPTQFS------SPTH---------------------KPSPS 966
              ..:.|.:||:.||..|...:|..:..|      ||.|                     .|...
Zfish   835 KAPFSRNLSRSSRSGDGPGGQTPPISPDSVDVFGFSPFHIIPTSGTQEDVFDQASLDESASPQQQ 899

  Fly   967 SQPQATFMHTPP----TPQTLPSTSSIR---TPTQPQAV--PAQSRPDYSRLH-----FDSQKAA 1017
            .|.|.:......    |.|...||:..|   |||..:..  |:...|:..|.|     .|||.:.
Zfish   900 RQKQRSLQKLSSRQRRTKQEASSTNGKRHHGTPTGGRKTNKPSFRTPERVRRHKKVGRRDSQSSN 964

  Fly  1018 QQPGTGGSK-NSDIFADILGQQGYSFGSKMNQCPRSINEMRKEDLF--KDMDPKK-VRIMEWTDG 1078
            :...|..|| |..|          |.|..|.:.....:|....|.|  |...|:. .|.....||
Zfish   965 EFLSTSDSKENISI----------SLGEVMEKAVALPSEEVSLDPFGAKPFHPQDGSRHQSLGDG 1019

  Fly  1079 K----KNNIRALLCSMHTVLWDN 1097
            |    .||.|....|:|:|...|
Zfish  1020 KSEINSNNGRPRTSSLHSVFDGN 1042

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	95/278 (34%)
		PTP_auxilin-like	404..573	CDD:350361	26/175 (15%)
		PTEN_C2	581..711	CDD:463081	21/150 (14%)
		PHA03247	<698..1037	CDD:223021	89/426 (21%)
		Herpes_BLLF1	<882..>999	CDD:282904	34/155 (22%)
		DnaJ	<1110..1150	CDD:99751
bmp2k	NP_001180469.1	STKc_NAK_like	36..309	CDD:270939	94/279 (34%)
		BMP2K_C	828..1081	CDD:464612	55/225 (24%)