DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aux and Tns3

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_008768557.1	Gene:	Tns3 / 360980	RGDID:	1564174	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	896	Identity:	180/896 - (20%)
Similarity:	310/896 - (34%)	Gaps:	254/896 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   410 NDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTE--PRLPPP 472
            ::||::::|.||:.:..|:...|.:| .:::::|...|:|:.....| :.|..::..  .:|.|.
  Rat   123 HELDLTYVTERIIAVSFPASCSEESY-LHSLQEVTRMLKSKHGDNYL-VLNLSEKRYDLTKLNPK 185

  Fly   473 VRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYA 537
            :..|      |.|:.|||.|..:.|:.....::||:||:.||::......| ....||.:.:.:.
  Rat   186 IMDV------GWPELHAPPLDKMCTICKAQESWLNSDPQHVVVIHCRGGKG-RIGVVISSYMHFT 243

  Fly   538 DLLREPEDAVQVFAVKRH-----TINLRPSEFRYLYYFGDIL------RPTPLLPHYKNTTLVSL 591
            ::....:.|:..||:|:.     :..:.||:.||:.:...:|      ..:||..|:     |.|
  Rat   244 NVSASADQALDRFAMKKFYDDKVSALMEPSQKRYVQFLSGLLSGAVKMNASPLFLHF-----VIL 303

  Fly   592 SCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAG---PGKI---VLPINLTACGD 650
            ...|   .......||.::::|       ..:|......:|..|   |.:|   :.|..|.. ||
  Rat   304 HGAP---SFDTGGACRPFLKLY-------QAMQPVYTSGIYNVGSENPSRIRIAIEPAQLLK-GD 357

  Fly   651 VTVVLFHAR-KGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDD------LPD--------- 699
            :.|..:|.: :...|.   .|.:.||:||.:.....|  |..::||.      .||
  Rat   358 IMVKCYHKKFRSATRD---VIFRLQFHTGAVQGYGLL--FGKEELDSACKDDRFPDYGKIELVFS 417

  Fly   700 --PEQ------------VTPRFCVSLSL---------------------------------AVTD 717
              ||:            ||..:..:..|                                 :.:|
  Rat   418 ATPEKIQGSEHLYSDQGVTVDYNTADPLIRWDSYENMSADGEVLHTQGPVDGSLYAKVRKKSASD 482

  Fly   718 SESPPSHKPPWMPA--KPKRSPAAL-FSSDLEYAEMLDNFVTKPSTRSSPPPGARKS-------- 771
            |..|.|  |..|||  .|......| .|||..::..   ......|.....||||:.
  Rat   483 SGIPSS--PQGMPATSSPDHGDHTLSVSSDSGHSTA---SARTDKTEERQTPGARRGLSPQEKAE 542

  Fly   772 -DRVSSPLVLPDVTETAHELPSPMPEPSPPIDLLNLNQQPSD----VPA--------------AD 817
             |::.|...|.| :..:|:            |:.::..:.|.    |||              .|
  Rat   543 LDQLLSGFGLED-SANSHK------------DMTDMRSKYSGTRHVVPAQVHVNGDAALKDRETD 594

  Fly   818 PLTSAKPSTDA-SFDLLGAFGDDD---STGIGSAPIPDILPPPPLQQPQPKINNDPFDIFGSVDQ 878
            .|....|..|. |.|.||.....:   ||.:|        |...|:..|..:.:|.|....:.|.
  Rat   595 ILDDEMPHHDLHSVDSLGTLSSSEGPQSTHLG--------PFACLKSSQNSLLSDGFGNGVAEDH 651

  Fly   879 GGVPSMKPSGFPPFVG-------------------SLPTFVAQPAATTNPSPTH---PARASADP 921
            .||.|       |.:|                   .|.....:|:|   |:||.   .:..|...
  Rat   652 NGVLS-------PDLGLGVDSVYERERMCGGREQKQLQPLSRKPSA---PTPTQAYGQSNYSTQT 706

  Fly   922 FANIADLATGLNLNF---NRSTLSGKSPVNTS----PQPTQFSSPTHKPSPSSQPQATFMH--TP 977
            :.....:.|....:|   ..:....:|.|:::    |.|....:|||..|.....|....:  .|
  Rat   707 WVRQQQMVTAHQYSFASDGEARHGSRSAVDSAGLAQPSPHIPVTPTHGTSSRVAVQRGISNGPNP 771

  Fly   978 PTPQTLPSTSSIR---------------------TPTQPQAVPAQSRPDYSRLHFDSQKAAQQPG 1021
            |..|.|..:.:::                     :|..|.....||....:||..:.....:...
  Rat   772 PDAQQLCPSKALQPRFPDDRVMNGVVHQELNPGPSPGSPTLDIDQSIEQLNRLILELDPTFEPIP 836

  Fly  1022 T-----GGSKNSDIFADILGQQGYSFGSKMNQCP---RSINEMRKEDLFKDMDPKKVRIMEWTDG 1078
            |     |.|.|..::.|.:| .|...|.:::...   ||..  |:.|     ||...|:.:.:.|
  Rat   837 THLSALGLSANGSMYPDGVG-SGLRCGGRLDPVDGPGRSPG--RQGD-----DPVGGRLRKLSIG 893

  Fly  1079 KKNNIRALLCSMHTVLWDNAKWQRC-EMSTMVTPTEVKKAYRRACLAVHPD 1128
            :.:|......:.....|..|..... .:.:..:|.::|:.   ...|..||
  Rat   894 QYDNDAGSQVTFSKCGWGKAGADSAPSLGSFSSPADIKET---VITAYPPD 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	34/165 (21%)
		DnaJ	<1110..1150	CDD:197617	5/19 (26%)
Tns3	XP_008768557.1	C1	39..85	CDD:237996
		PTPc_DSPc	190..304	CDD:214469	29/119 (24%)
		PTEN_C2	291..417	CDD:287393	32/146 (22%)
		SH2_Tensin_like	1285..1401	CDD:198181
		PTB_tensin	1425..1556	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810