Protein Alignment aux and Nak

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_477165.1
• Gene: Nak / 35154
• FlyBaseID: FBgn0015772
• Length: 1488
• Species: Drosophila melanogaster
• Alignment Length: 1261
• Identity: 280/1261 - (22%)
• Similarity: 429/1261 - (34%)
• Gaps: 386/1261 - (30%)

  Fly    36 NDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQ----DVQTGTEYALKRLIGADMQASTAIINEI 96
            |.|||:|..|....:.::.|:||||:|.|::|:    ...:.|:|||||:...:.........||
  Fly    32 NSFVGKVFTVGRVTVTVEDVLAEGGFAMVFLARGNGGGSSSATKYALKRMYVNNEHDLNVAKREI 96

  Fly    97 NIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGGSLVDCFRTNNAPFNPTCVLRIFYQ 161
            .|...||||:||:.:|.||.| |:.....:.|||...||...|.......:..|....||.||..
  Fly    97 QIASNLSGHKNIIGYVDSSIT-PTGNGVCEVLLLMPYCKHHMLAMMNARLHVGFTEPEVLNIFCD 160

  Fly   162 MARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGSASTEVLSPTFEWSANQRSMLEDQLN 226
            :|.||:.||....||.|||:|:||.|..:.....|||||||:.:.|:|    ..:..:::::::.
  Fly   161 IAEAVSRLHYCQTPIIHRDLKVENILQTDAGNFVLCDFGSATAKTLNP----QQHGVTVVQEEIQ 221

  Fly   227 TVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPYED------GGKLRIINAN--- 282
            ..||..||:|||:|.:....|..|.|||||||:||.||:...|:.:      .|:..|.:::
  Fly   222 KYTTLSYRAPEMIDLYGGKSITTKADIWALGCMLYKLCFFSLPFGESTLAIQNGQFSIPDSSKYS 286

  Fly   283 --------YMLPPDPQ-----YQCFSDIIRGCLKVNPFERLDIT------------------MVL 316
                    |||.||.:     :|......|...|.||.:.|..|                  .:.
  Fly   287 KGMHQLIKYMLEPDMEKRPNIWQVCEVAFRLAGKDNPVQNLHKTPIPNFDLLVVPPFESEAKRIS 351

  Fly   317 EGLAALAETHNWSL-------------KG--------PLDLHIMPIES----------------- 343
            ...:..|:..|.|:             ||        ||.|.:.|..|
  Fly   352 AAASKAAKAQNVSVVEAGTSVAPRSRPKGSSSVHGGNPLGLGLPPSPSPRQNITSPQPQPQPVVE 416

  Fly   344 -----------------------LPAESPL-KSSAYSEVYTEPLSAAIPSSY------------- 371
                                   .||.|.| :||.|.:.:.||.:|.||:.:
  Fly   417 QFQANFPAMPPAVPPPPQAVTPAAPAASKLFESSGYPDPFNEPAAAVIPTEFLPAAEEPNKEEVP 481

  Fly   372 --------NGHGSLLSSLR-GGAGTLLKNIKDTS----TKVMQTMQQSLA--RNDLDISHITSRI 421
                    ....|:|:..: .|.|...:|:.|||    |...:| .|.||  .|:|.......:.
  Fly   482 QDLNVIAGTPTKSMLTPPKPSGGGGHRRNVSDTSAFNKTFANET-SQFLAPFNNNLAAMGDGQQT 545

  Fly   422 LVMPCPSDGFESTYKTNNIEDVRLSLESRFVP------QKLSIYN-------FGQRTEPRLPPPV 473
            |.....:.|.   |.::......:|:.....|      :::..:|       |.|.||..:
  Fly   546 LASAASNPGI---YASSTANSAAVSISELMKPGQTAVEKRVEAWNPFEEEQPFSQMTEDHI---- 603

  Fly   474 RTVEA--------GSVYGCPQAHAPNLQGLFTV-SADMYNFLNAD---PKSVVIVQTGDSGGCTA 526
              .||        ||            ||..|. ||...:.|...   |.:||...|...|....
  Fly   604 --FEAEFDKIRQRGS------------QGSITAKSASTTSTLTPTEQIPSAVVAPVTAAPGAVPP 654

  Fly   527 ATVICALLMYADLLREPEDAVQVFA----VKRHTINLRPSEFRYLYYFGD--------------- 572
            ..:..|:..|...:.|.......|:    ::....:||.:..:::.....
  Fly   655 PPIAAAVSPYPSQVSEDPFGSAPFSLPPGLREKASSLRKTGAKFIGVSSGGTGGGVATPIGLVAG 719

  Fly   573 -------------ILRPTPLLPHYKNTTLVS-----LSCQPVPRMTKARDGCRIYMEVYCNGNLL 619
                         :|.||..:...:.|:|:|     ..|.....:..|.:|...|::      |.
  Fly   720 GANTATSSNSSKWMLSPTLEVSSEEKTSLISKLKTDSECGIPGAVGGAGEGVSGYVK------LP 778

  Fly   620 LSTLQDYEKMR----------------LYQ----AGPGKIVLPINLTACGDVTVVLFHARKGMVR 664
            :.....|||:|                .:|    .|.|.|...:.:     ||..|
  Fly   779 VEDRNKYEKLRSKDQPTSDDSDSEASEFFQQDSDEGGGGIFRQMQM-----VTSNL--------- 829

  Fly   665 PQGL-KICQFQFN----TGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSL--AVTDSESPP 722
            |:.: ||.|..::    |..:|..:.|       .|....|.....:....|:|  |...:::..
  Fly   830 PETIHKIQQVAYHKVDKTAHLPIVKKL-------RDKTKKPTTAAHQAAQQLNLMAAAVAAQAEE 887

  Fly   723 SHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKP----STRSSPPP----GARKSDRVSSPLV 779
            :.|     |......:...:|||. ||..|.|...|    :.:..|.|    |..:|.:..|...
  Fly   888 AAK-----AAESDGDSIGSASDLR-AEDDDLFDENPRQTQAKQRRPLPTEMDGISESVKTCSSSA 946

  Fly   780 LPDVTE--TAHE--LPSPMPEPSPPIDLLNLNQQPSD----VPAADPLTSAKPSTDASFDLLGAF 836
            .....|  |.||  :.|.:        ::.:..:..|    ....||...::..:..|.|||..|
  Fly   947 YHAECESVTTHEDDVRSRV--------VVKVRMRKKDRALVTATGDPSAPSEELSPTSSDLLHKF 1003

  Fly   837 GD-----DDSTGIGS--------APIPDILPPPPLQQPQPKINNDPFDIFGSVDQGGVPSMKPSG 888
            ||     ||....||        :|:..|||      ..|.:.....|:|..     .|...|.|
  Fly  1004 GDRPLLLDDELDYGSGESKSSTESPVAPILP------TNPDVQESEEDVFAL-----APFKLPVG 1057

  Fly   889 FPPFVGSLPTFVAQPAATTNPSPTHP---------ARASADPFANIADLATGLNLNFNRSTLSGK 944
            .|        ...:......|.|:.|         :.|..||..|.|.....|....|
  Fly  1058 VP--------LKRKTKPKAKPKPSEPEMWTSTPVKSAAVGDPSTNFASFPAQLTPTNN------- 1107

  Fly   945 SPVNTSPQPTQFSSPTHKP----SPSSQP----QATFMHTPPTPQTLPSTSSIRTPTQPQAVPAQ 1001
              |..|.|..:|:.|...|    :.::|.    |.......|.||.      |||        .:
  Fly  1108 --VGNSAQLDEFNEPIFNPFQENAQNTQSGETNQCDLFGLEPFPQV------IRT--------IE 1156

  Fly  1002 SRPDYSRLHFDSQKAAQQPGTGGSKN 1027
            ..|.:.::|       |.|....:.|
  Fly  1157 QNPQHHQIH-------QFPSHNNNNN 1175

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	99/320 (31%)
		PTP_auxilin-like	404..573	CDD:350361	36/227 (16%)
		PTEN_C2	581..711	CDD:463081	28/159 (18%)
		PHA03247	<698..1037	CDD:223021	78/378 (21%)
		Herpes_BLLF1	<882..>999	CDD:282904	28/133 (21%)
		DnaJ	<1110..1150	CDD:99751
Nak	NP_477165.1	STKc_NAK_like	42..319	CDD:270939	93/281 (33%)
		DUF1633	<438..>619	CDD:116408	42/202 (21%)