Protein Alignment aux and Tns3

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: XP_011242029.1
• Gene: Tns3 / 319939
• MGIID: 2443012
• Length: 1553
• Species: Mus musculus
• Alignment Length: 1033
• Identity: 195/1033 - (18%)
• Similarity: 325/1033 - (31%)
• Gaps: 388/1033 - (37%)

  Fly   388 LLKNIKDTSTKVMQ-TMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRF 451
            :|:..|.:.|.|:. .|:.|   ::||::::|.||:.:..|:...|.:| .:::::|...|:.:.
Mouse    98 VLRCDKPSRTVVLSPAMEDS---HELDLTYVTERIIAVSFPASCSEESY-LHSLQEVTRMLKCKH 158

  Fly   452 VPQKLSIYNFGQRTE--PRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVV 514
            ....| :.|..::..  .:|.|.:..|      |.|:.|||.|..:.|:.....::||.||:.||
Mouse   159 GDNYL-VLNLSEKRYDLTKLNPKIMDV------GWPELHAPPLDKMCTICKAQESWLNNDPQHVV 216

  Fly   515 IVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRH-----TINLRPSEFRYLYYFGDIL 574
            ::......| ....||.:.:.:.::....:.|:..||:|:.     :..:.||:.||:.:...:|
Mouse   217 VIHCRGGKG-RIGVVISSYMHFTNVSASADQALDRFAMKKFYDDKISALMEPSQKRYVQFLSGLL 280

  Fly   575 ------RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQ 633
                  ..:||..|:       :....||..... ..||.::::|       ..:|......:|.
Mouse   281 SGAMKMNTSPLFLHF-------VIMHGVPSFDTG-GACRPFLKLY-------QAMQPVYTSGIYN 330

  Fly   634 AG---PGKI---VLPINLTACGDVTVVLFHAR-KGMVRPQGLKICQFQFNTGFIPEPETLITFTN 691
            .|   |.:|   :.|..|.. ||:.|..:|.: :...|.   .|.:.||:||.:.....|  |..
Mouse   331 VGSENPSRIRIAIEPAQLLK-GDIMVKCYHKKFRSATRD---VIFRLQFHTGAVQGYGLL--FGK 389

  Fly   692 QDLDD------LPD-----------PEQ------------VTPRFCVSLSLAVTDS--------- 718
            ::||.      .||           ||:            ||..:..:..|...||
Mouse   390 EELDSACKDDRFPDYGKIELVFSATPEKIQGSEHLYSDQGVTVDYNTADPLIRWDSYENMSADGE 454

  Fly   719 ----ESP-----------PSHKPPWMPAKPKRSPAALFSS----DLEYAEMLDNFVTKPSTRSSP 764
                :.|           .|.....:|:.|:..||.  ||    |...:...|:..:..|.|:..
Mouse   455 VLHTQGPVDGSLYAKVRKKSASDTGIPSSPQGMPAT--SSPDHGDHTLSVSSDSGHSTASARTDK 517

  Fly   765 -----PPGARK-------------------SDRVSSPLVLPDV----TETAHELPSP-------- 793
                 .||||:                   .|..||...:.|:    :.|.|.:|:.
Mouse   518 TEERLTPGARRGLSPQEKAELDQLLSGFGLEDSASSHKDMTDMRSKYSGTRHVVPAQVHVNGDAA 582

  Fly   794 --------MPEPSPPIDLLNLNQ----QPSDVPAA---DPLTSAKPS------------------ 825
                    :.:..|..||.:::.    ..|:.|.:   .|.|..|.|
Mouse   583 LKDRETDILDDEMPHHDLHSVDSLGTLSSSEGPQSTHLGPFTCLKSSQNSLLSDGFGNGVAEDHN 647

  Fly   826 ----------TDASFD------------------------------------------------- 831
                      .|..:|
Mouse   648 GVLSPDLGLGVDTLYDRERMCGGREQKPLQPLLRKPSAPTPVQAYGQSNYSTQTWVRQQQMVAAH 712

  Fly   832 ----------LLGAFGDDDSTGIGSAP--IPDILP-------------------PPPLQQ--P-- 861
                      .||:....|:||:...|  || :.|                   ||..||  |
Mouse   713 QYSFASDGEARLGSRSTVDNTGLAQPPPHIP-VTPNRGASSRVAVQRGISNGPNPPDTQQLCPGK 776

  Fly   862 --QPKINNDPFDIFGSVDQ----GGVPSMKPSGFPPFVGSLPTFVAQPAATTNPSPTH------- 913
              ||:..:|  .:...|.|    |..|..........:..|...:.:...|..|.|||
Mouse   777 ALQPRFQDD--RVTNGVHQEPNTGSSPGSPTLDIDQSIEQLNRLILELDPTFEPIPTHLNALGIS 839

  Fly   914 --------------------------PARASADPF-ANIADLATGLNLNFNRSTLS------GKS 945
                                      |.|...||. ..:..|:.|...|...|.::      ||:
Mouse   840 AVCPDGVGSGLRCSGRLDSVDGPGRSPGRQGDDPIGGRLRKLSIGQYDNDAASQVTFSKCGWGKA 904

  Fly   946 PVNTSPQPTQFSSP--------THKPS---------PSSQ-------------PQATFMHT---- 976
            .|:.:|....||||        |..||         |:|:             |:..::.|
Mouse   905 GVDPAPSLGSFSSPEDIKETVITAYPSDLNMIDGRIPNSKESSMCLTPSFPVSPETPYVKTSPRY 969

  Fly   977 ----PPTPQTLPSTSSIRTPTQPQAVPAQSRPDYSRLHFDSQKAAQQPGTGGSKNSDIFADILGQ 1037
                ||.|| |.|.:|:....:|:..|          ...|..........|.|.:.:.||:...
Mouse   970 PPFSPPEPQ-LSSPASLHKGREPRGCP----------EIISHTVGMSESPVGPKPTMLRADMPAT 1023

  Fly  1038 QGYS--FGSKMNQCPRSIN--EMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMH 1091
            ..:.  |.|   .|..|.|  ..|:|.     .|...|  :|.:....:...||.:.|
Mouse  1024 PNFQQVFAS---SCTVSSNGPGQRRES-----PPSAER--QWVESSPKSTLTLLGNSH 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864
		PTP_auxilin-like	404..573	CDD:350361	40/175 (23%)
		PTEN_C2	581..711	CDD:463081	33/165 (20%)
		PHA03247	<698..1037	CDD:223021	107/636 (17%)
		Herpes_BLLF1	<882..>999	CDD:282904	38/194 (20%)
		DnaJ	<1110..1150	CDD:99751
Tns3	XP_011242029.1	C1_TNS3_v	33..88	CDD:410439
		PTP_tensin-3	121..279	CDD:350409	38/166 (23%)
		PTEN_C2	286..412	CDD:463081	31/146 (21%)
		PHA03307	645..>1077	CDD:223039	79/451 (18%)
		PHA03247	<907..1186	CDD:223021	39/186 (21%)
		SH2_Tensin_like	1276..1392	CDD:198181
		PTB_tensin	1416..1547	CDD:269924