Protein Alignment aux and Tns2

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: XP_017450825.1
• Gene: Tns2 / 315326
• RGDID: 1310917
• Length: 1454
• Species: Rattus norvegicus
• Alignment Length: 767
• Identity: 161/767 - (20%)
• Similarity: 273/767 - (35%)
• Gaps: 236/767 - (30%)

  Fly   206 VLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYRKHPY 270
            :|.|..:.|::|                .||.:..:.|.||:.|.|           :..|....
  Rat    24 LLVPRAQCSSSQ----------------ESPTLSRSTSKNPVHPSV-----------MGMRSQAV 61

  Fly   271 EDGGKLRIINANYMLPPD-PQYQCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPL 334
            |:|           :||. |::..|      |: |.|.:              ||.|::
  Rat    62 EEG-----------VPPSVPRWTSF------CI-VKPRK--------------AEPHSF------ 88

  Fly   335 DLHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNGHG----------------SLLSS--- 380
                       .|...:..|       |:.|....:.:|.|                .:.||
  Rat    89 -----------REKVFRKKA-------PVCAVCKVTIDGTGVSCRVCKVATHRKCEAKVTSSCQA 135

  Fly   381 -----LRGGAGTL--LKNIKDTS----TKVMQTMQQSLA-------RNDLDISHITSRILVMPCP 427
                 ||.....:  ::::..|.    :|...|:.:|.:       |.|||::::|.|||....|
  Rat   136 LPPAELRRNTAPVRRIEHLGSTKSLNHSKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFP 200

  Fly   428 SDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTE--PRLPPPVRTVEAGSVYGCPQAHAP 490
            :...|..:: .::.::...|:|:. ..|..::|..::..  .||.|.|..      :|.|:.|||
  Rat   201 ARPDEQRHR-GHLRELAHVLQSKH-RDKYLLFNLSEKRHDLTRLNPKVHD------FGWPELHAP 257

  Fly   491 NLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRH 555
            .|..|.::...|..:|:|||:.||::....|.| ....::.|.:.|:.:....:.|:....:::.
  Rat   258 PLDKLCSICKAMETWLSADPQHVVVLYCKGSKG-KLGVIVSAYMHYSKISAGADQALATLTMRKF 321

  Fly   556 -----TINLRPSEFRYLYYFGDIL------RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIY 609
                 .:.|:||:.||:.||..:|      ..:||..||...        ||....:...|.:.:
  Rat   322 CEDKAAMELQPSQHRYVGYFSGLLSGSIRMNSSPLFLHYVFV--------PVLPAFEPNTGFQPF 378

  Fly   610 MEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTAC----GDVTVVLFHARKGMVRPQGLKI 670
            :::|.:..|:      |.....:..|||...:.|:|...    |||.|..:|  ||........:
  Rat   379 LKIYQSMQLV------YTSGVYHITGPGPRQICISLEPALLLKGDVMVTCYH--KGGQGTDRTLV 435

  Fly   671 CQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKR 735
            .:.||:|..|..|.  :.|....||:....|    ||....|:....|.||...|    ...|:.
  Rat   436 FRVQFHTCTIHGPR--LNFPKDQLDEAWADE----RFPFQASVEFVFSSSPEKVK----GNTPRN 490

  Fly   736 SPAALFSSDLEYAEMLDNFVTKPSTR--SSPPPGARKSDRVSSPLV----------------LPD 782
            .|:.          .:|..:|:|:.|  |.........|.|...|.                :|.
  Rat   491 DPSV----------SVDYNMTEPAVRWDSYENFNQHHEDSVDGSLAHTRGPLDGSPYAQVQRVPR 545

  Fly   783 VTETAHELPSPMPE-PSPPIDLLNLN-----------QQPSDVPAADPLTSAKPSTDASFD-LLG 834
            .|.     |:|.|| |.||  :|:::           :..::.|...|.|:|:..   ..| |||
  Rat   546 QTP-----PAPSPELPPPP--MLSVSSDSGHSSTLTTEHTAESPGRPPPTAAERQ---ELDRLLG 600

  Fly   835 AFGDDDSTGIGSAPIPDILPPPPLQQPQPKINNDPFDIFGSVDQGGVPSMKP 886
            ..| ..|.|.|:.....||.    .:.||.:.       |.:..|..|..:|
  Rat   601 GCG-VASAGRGAGRETAILD----DEEQPSVG-------GGLHLGMYPGHRP 640

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	23/120 (19%)
		PTP_auxilin-like	404..573	CDD:350361	45/182 (25%)
		PTEN_C2	581..711	CDD:463081	31/133 (23%)
		PHA03247	<698..1037	CDD:223021	48/220 (22%)
		Herpes_BLLF1	<882..>999	CDD:282904	2/5 (40%)
		DnaJ	<1110..1150	CDD:99751
Tns2	XP_017450825.1	C1_TNS2	84..137	CDD:410437	10/76 (13%)
		PTP_DSP_cys	186..344	CDD:475123	41/166 (25%)
		PTEN_C2	351..478	CDD:463081	34/148 (23%)
		PHA03247	<833..1197	CDD:223021
		SH2_Tensin_like	1181..1294	CDD:198181
		PTB_tensin	1318..1450	CDD:269924