DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and Dnajc6

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_006238508.1	Gene:	Dnajc6 / 313409	RGDID:	1309900	Length:	968	Species:	Rattus norvegicus

Alignment Length:	950	Identity:	305/950 - (32%)
Similarity:	443/950 - (46%)	Gaps:	177/950 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   348 SPLKSSAYSEVYTEPLSAAIPS---SYNGHGSLLSSLRGGAGTLLKN--------IKDTSTKVMQ 401
            ||.:...:....|:...|:.|.   ||.  |.|...::||||.|..|        :||||::|:|
  Rat    47 SPARQPPHRASTTDSSGASSPDMEPSYG--GGLFDMVKGGAGRLFSNLKDNLKDTLKDTSSRVIQ 109

  Fly   402 TMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTE 466
            :: .|..:.|||.:::||||:||..|.|..:..:: |.::|:|..|:||.: ...::||..
  Rat   110 SV-SSYTKGDLDFTYVTSRIIVMSFPMDSVDIGFR-NQVDDIRSFLDSRHL-DHYTVYNLS---- 167

  Fly   467 PRLPPPVRTVEAGS-VYGC--PQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAAT 528
               |...||.:..| |..|  |...||:|..||.|..:|||:|..:||:|.:|...| |...::.
  Rat   168 ---PKSYRTAKFHSRVSECSWPIRQAPSLHNLFAVCRNMYNWLLQNPKNVCVVHCLD-GRAASSI 228

  Fly   529 VICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHYKNTTLVSLSC 593
            ::.|:.::.:|...|..||::...||..|.|.||..|||.|..|:|...|..||:|..|:.:::.
  Rat   229 LVGAMFIFCNLYSTPGPAVRLLYAKRPGIGLSPSHRRYLGYMCDLLADKPYRPHFKPLTIKAITV 293

  Fly   594 QPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHA 658
            .|:|...|.|:|||.|.:|......:.||..|:|:|:.|:...|||.:|:|:|..|||.|.::|.
  Rat   294 SPIPFFNKQRNGCRPYCDVLIGETKIFSTCTDFERMKEYRVQDGKIFIPLNITVQGDVIVSMYHL 358

  Fly   659 RKGM-----VRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDS 718
            |..:     .:....:|.|.||::||||...|::.||..:||....||:....|.|:|.:.|...
  Rat   359 RSTIGSRLQAKVTNTQIFQLQFHSGFIPLDTTVLKFTKPELDACDVPEKYPQLFQVTLDIEVQPQ 423

  Fly   719 ESPPSHKPPWMPAKPKR-SPAALFSSDLEYAEMLDNFVTKPSTRSSPPPGAR------------- 769
            :......|||.....|. :|:.||||..|:.:.|......|:  ..||...|
  Rat   424 DKVIDLTPPWEHYCTKDVNPSILFSSQQEHQDTLALGGQAPA--DLPPDHPRNLGQGGFFASLCW 486

  Fly   770 ---KSDR------------------------VSSPLVLPDVTETAHELPSP--------MPEPSP 799
               ||::                        :|||....| .:..|....|        .|.|..
  Rat   487 QDQKSEKSRCEEDHAALVNQESEQSDDELLTLSSPHGNAD-GDKPHGAKKPGKKQQEPAAPPPPE 550

  Fly   800 PIDLLNLNQQPSDVPA-ADPLTSAKPSTDASFDLLGAFGDDDSTGIGSAPIPDILPP--PPLQQP 861
            .:|||.|  :.|||.. ..||.:...:::...||.|..|.......|...:.|:..|  |...|.
  Rat   551 EVDLLGL--EGSDVSTNFSPLAAPPSNSELLSDLFGGGGATGPAQAGQVGVEDVFHPSGPASAQS 613

  Fly   862 QPK-----------------INNDPFDIFGSVDQGGVPSMKPSGFPPFVGS-LPTFVA------Q 902
            .|:                 ...|||         |.|: ||.| ...:|| |.|..|      |
  Rat   614 TPRRATTSASASPTLRVGEGATFDPF---------GAPA-KPPG-QDLLGSFLNTSNASSDPFLQ 667

  Fly   903 PAATTNPSPTHPARASADPFANI-ADLATGLNLNFNRSTLS-GKSPVNTSPQPTQFSSPTHKPSP 965
            |  |.:||||  ..||:.|..|| .|:|.|.:.:....... |.....|||..:...:|||:..|
  Rat   668 P--TRSPSPT--VHASSTPAVNIQPDIAGGWDWHAKPGGFGMGSKSAATSPTGSTHGTPTHQSKP 728

  Fly   966 SS-QP--------QATFMHTPPTPQTL-----PSTSSIRTPTQP--------------QAVP--- 999
            .: .|        .::|...|.||..|     |.:|..:...||              ||.|
  Rat   729 QTLDPFADLGTLGSSSFASKPTTPTGLGGGFPPLSSPQKASPQPMGGGWQQPAGYNWQQAQPKPQ 793

  Fly  1000 -------AQSRPDYSRLHFDSQKAAQQPGTGGSKNSD------IFADILGQQGYSFGSKMNQCPR 1051
                   .|:||:|: :.|.:..|.|.....||.|.:      .|.|:|..||:: ..|..:.||
  Rat   794 SSMPHSSPQNRPNYN-VSFSAMPAGQSDRGKGSTNLEGKQKAADFEDLLSSQGFN-AHKDKKGPR 856

  Fly  1052 SINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLW-DNAKWQRCEMSTMVTPTEVK 1115
            :|.|||||::.|:|||:|::|:||.:||:.||||||.:|||||| ...||:...|:.:|||.:||
  Rat   857 TIAEMRKEEMAKEMDPEKLKILEWIEGKERNIRALLSTMHTVLWAGETKWKPVGMADLVTPEQVK 921

  Fly  1116 KAYRRACLAVHPDKHNGTENEEIAKLIFMELNNAWTDFEN 1155
            |.||||.|.|||||..|...|:.||:||||||:||::|||
  Rat   922 KVYRRAVLVVHPDKATGQPYEQYAKMIFMELNDAWSEFEN 961

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	48/134 (36%)
		DnaJ	<1110..1150	CDD:197617	25/39 (64%)
Dnajc6	XP_006238508.1	PTEN_C2	281..419	CDD:287393	49/137 (36%)
Dnajc6	XP_006238508.1	DnaJ	<916..961	CDD:99751	28/44 (64%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	125	1.000	Domainoid score	I5338
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	527	1.000	Inparanoid score	I1190
OMA	1	1.010	-	-		QHG45626
OrthoDB	1	1.010	-	-		D296562at33208
OrthoFinder	1	1.000	-	-		FOG0001565
OrthoInspector	1	1.000	-	-		otm46271
orthoMCL	1	0.900	-	-		OOG6_104372
Panther	1	1.100	-	-	O	PTHR23172
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2131
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	11	10.980