DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and Tns1

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_038939258.1	Gene:	Tns1 / 301509	RGDID:	68427	Length:	1937	Species:	Rattus norvegicus

Alignment Length:	972	Identity:	200/972 - (20%)
Similarity:	347/972 - (35%)	Gaps:	247/972 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   256 LGCILYFLC---------------------YRKHPYEDGGKLRIINANYMLPPD----PQYQCFS 295
            :||.:..:|                     .|....|.||...|.....:|.|:    |:...|.
  Rat     1 MGCTVSLVCCEALEPLPSCGPQPPGTPPGPARPERSEPGGAASIQRRRLLLQPEDLEAPKTHHFK 65

  Fly   296 DIIRGCLKVNPFERLDITMVLEGLAALAETHNWSLKGPLDLHIMPIESLPAESPLKSSAYSEVYT 360
              ::...||.|.......:..||  .:.:..::|........:    :.|...| .|.....:.|
  Rat    66 --VKAFKKVKPCGVCRQAITREG--CICKVCSFSCHRKCQAKV----AAPCVPP-SSHELVPIAT 121

  Fly   361 EPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDT-STKVMQTMQQ---------SLARN----- 410
            |    ::|.:....|.  ...|||:..  ||:::. |.:|..::|.         ||:||
  Rat   122 E----SVPKNVVDVGE--GDCRGGSTP--KNLEEAGSMRVSPSIQPQPQPQPQPISLSRNLSVSR 178

  Fly   411 ------DLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRL 469
                  :||:.:||.||:.:..||...|..:: :|:.:|...|:|:.....| ::|..::.
  Rat   179 AMEDSCELDLVYITERIIAVSFPSTANEENFR-SNLREVAQMLKSKHGGNYL-LFNLSEQR---- 237

  Fly   470 PPPVRTVEAGSV-YGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICAL 533
             |.:..:.|..: :|.|..|.|.|:.:.:|...|..:|||||.:||::....:.| ....||.|.
  Rat   238 -PDITKLHAKVLEFGWPDLHTPALEKICSVCKAMDTWLNADPHNVVVLHNKGNRG-RIGVVIAAY 300

  Fly   534 LMYADLLREPEDAVQVFAVKRHTINL-----RPSEFRYLYYFGDILRPT------PLLPHYKNTT 587
            :.|:::....:.|:..||:||...:.     :||:.||::||..:|..:      ||..|:
  Rat   301 MHYSNISASADQALDRFAMKRFYEDKIVPIGQPSQRRYVHYFSGLLSGSIKMNNKPLFLHH---- 361

  Fly   588 LVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGK------IVLPINLT 646
               :....:|.. :::.|||.::.:|       ..:|......:|.. ||.      |.:...|.
  Rat   362 ---VIMHGIPNF-ESKGGCRPFLRIY-------QAMQPVYTSGIYNI-PGDSQASICITIEPGLL 414

  Fly   647 ACGDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSL 711
            ..||:.:..:|  |....|....|.:.||:|..|  .:..:.|..:|||:
  Rat   415 LKGDILLKCYH--KKFRSPARDVIFRVQFHTCAI--HDLGVVFGKEDLDE--------------- 460

  Fly   712 SLAVTDSESPPSHKPPWM----PAKPKRSPAALFSSDLEYAEMLDNFVTKPSTRSSPPPGARKSD 772
              |..|...|...|..::    |.|            ::..|.|:|           .|......
  Rat   461 --AFKDDRFPDYGKVEFVFSYGPEK------------IQGMEHLEN-----------GPSVSVDY 500

  Fly   773 RVSSPLVLPDVTE--TAHE---LPSPMPEPSPPID---LLNLNQQPSDVPAADPLTSAKPSTDAS 829
            ..|.||:..|..:  ..|.   :...:.....|:|   ...:.::.|...::.|:|:|:|:..|:
  Rat   501 NTSDPLIRWDSYDNFNGHREDGMEEVVGHTQGPLDGSLYAKVKKKDSLNGSSGPITTARPALSAT 565

  Fly   830 FD----LLGAFGDDDS------TGIGSAPIPDILPPPPLQQPQPKINNDPFDIFGSVD---QGGV 881
            .:    .|....|..:      |.....|:......|....||.|...|.......||   ||.:
  Rat   566 PNHVEHTLSVSSDSGNSTASTKTDKTDEPVSGAAIAPAALSPQEKKELDRLLSGFGVDREKQGAM 630

  Fly   882 PSMKPSGFPPFVGSLPTFVAQPAATTNPSPTH---PARAS------ADPFANIADLATGLNLNFN 937
            ...:.....|  |..|| |:.|.....|:..|   .|.||      .|....|.|..:|.::. .
  Rat   631 YRAQQLRSHP--GGGPT-VSSPGRHIVPAQVHVNGGALASERETDILDDELPIQDGQSGGSMG-T 691

  Fly   938 RSTLSGKSPVNTS-----------------PQPTQ---------FSS-----PTH-------KPS 964
            .|:|.|.:  |||                 |.||:         :.|     |.|       :||
  Rat   692 LSSLDGVT--NTSEGGYPETLSPLTNGLDKPYPTEPILNGGGYPYESANRVVPVHSSHSAPIRPS 754

  Fly   965 PSSQP-QATFMHTPPTPQTLPSTSSIRTPTQPQAV-PAQSRPDYSRLHFDSQKAAQQPGTGGSKN 1027
            .|:|. ...:....|.|......:|......|..: .:||.||.      ..:..|.|..|||..
  Rat   755 YSAQEGLGGYQREGPHPAWSKQVTSAHRGYDPSGLFRSQSFPDV------EPQLPQAPARGGSSR 813

  Fly  1028 SDIFADILGQQGYSFGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCS 1089
            ..:      |:|.:...:..|..:...:.:::...:...|..      ...:::.:::|.||
  Rat   814 EAV------QRGLNSWQQQQQQQQQQQQQQQQQQQQQPHPPP------RQQERSPLQSLACS 863

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357	17/94 (18%)
		S_TKc	51..317	CDD:214567	15/85 (18%)
		PTEN_C2	581..711	CDD:287393	26/135 (19%)
		DnaJ	<1110..1150	CDD:197617
Tns1	XP_038939258.1	C1_TNS1_v	57..112	CDD:410438	10/63 (16%)
		PTP_DSP_cys	187..345	CDD:421693	46/165 (28%)
		PTEN_C2	352..478	CDD:402161	32/162 (20%)
		PHA03247	<718..1143	CDD:223021	30/164 (18%)
		PHA03247	<1091..1643	CDD:223021
		SH2_Tensin_like	1661..1776	CDD:198181
		PTB_tensin	1798..1931	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810