DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and Aak1

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_036022028.1	Gene:	Aak1 / 269774	MGIID:	1098687	Length:	1302	Species:	Mus musculus

Alignment Length:	1239	Identity:	275/1239 - (22%)
Similarity:	442/1239 - (35%)	Gaps:	335/1239 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 YFSSSEVNGAAGNGAPEALGG----RLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQT 72
            :|.|....|::|.|:..:.||    .|.:.::|:|..:...::.:..|:||||:|.|::.: ...
Mouse     4 FFDSRREQGSSGLGSGSSGGGGSSSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFALVFLVR-TSN 67

  Fly    73 GTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGG 137
            |.:.||||:...:.........||.|.:.||||:|||.::.||....|:....:.|:|.:.|:||
Mouse    68 GVKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG 132

  Fly   138 SLVDCFRTN-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGS 201
            .:|:..... ...|....||:||.....|||.||....||.|||:|:||.|:.:.....||||||
Mouse   133 QVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGS 197

  Fly   202 ASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYR 266
            |:.:..:|    .|...:.:||::...||..||:|||::.:|...|..|.|||||||:||.|||.
Mouse   198 ATNKFQNP----QAEGVNAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF 258

  Fly   267 KHPYEDGGKLRIINANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSL 330
            ..|:.: .::.|.:.::.:|.:.:| |....:||..|:.:|.:|.||..|
Mouse   259 TLPFGE-SQVAICDGSFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQV--------------- 307

  Fly   331 KGPLDLHIMPIESLPAESPLKSSAYSEVYTEPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDT 395
                  .....:.|..|.|:.:     |...|:.|.:|                     :.:|.:
Mouse   308 ------SYFSFKLLKKECPVPN-----VQNSPIPAKLP---------------------EPVKAS 340

  Fly   396 STKVMQTMQQSLARNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYN 460
            ...|.:|  |..||            |..|.|:              ...|:..|..|:.
Mouse   341 EAAVKKT--QPKAR------------LTDPIPT--------------TETSIAPRQRPKA----- 372

  Fly   461 FGQRTEPR---LP--PPVRTVEAGSVYGCPQAHAP-NLQGLF-TVSADMYNFLNADPKSVVIVQT 518
             || |:|.   ||  |.:...:..:|...|||..| |..||. :||         .||:
Mouse   373 -GQ-TQPNPGILPIQPALTPRKRATVQPLPQAAGPSNQPGLLPSVS---------QPKA------ 420

  Fly   519 GDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHTINLRPSEFRYLYYFGDILRPTPLLPHY 583
                   .||              |...:|         :.:|.:.:        ..|||.....
Mouse   421 -------QAT--------------PSQPLQ---------SSQPKQPQ--------APPTPQQTPA 447

  Fly   584 KNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTAC 648
            ..|..:....|..|:..:..               ||...|..::.......|.:   |..
Mouse   448 TQTQGLPTQAQATPQHQQQH---------------LLKQQQQQQQQPQQPTAPPQ---PAG---- 490

  Fly   649 GDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPET---------------LITFTNQDLDDLP 698
                  .|:.::...:.|..:..|||.......:|.|               :..|.:|......
Mouse   491 ------TFYQQQQQQQQQQAQTQQFQAVHPAAQQPVTAQFPVGSQGGAQQQLMQNFYHQQQQQQQ 549

  Fly   699 DPEQVTPRFCV---SLSLAVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPST 760
            ..:|:..:...   ..::.|..|::.|:..|   .|...:.|..:.:...:..::.   .|.|.|
Mouse   550 QQQQLMAQQAALQQKTAVVVPQSQAQPATAP---QAAAAQEPGQIQAPVRQQPKVQ---TTPPPT 608

  Fly   761 ------RSSPPPGARKSDRVSSPLVLPDVTETA----------HELPSPMPEPSPPIDLLNLNQQ 809
                  .|..||.:.|:.|.....:|.|||.:|          ..|.:...|.|     ||.::.
Mouse   609 IQGQKVGSLTPPSSPKTQRAGHRRILSDVTHSAVFGVPASKSTQLLQAAAAEAS-----LNKSKS 668

  Fly   810 PSDVPAADPLTSAKPSTDAS-FDLLGAFGDDDSTGIGSAPIPDILPPPPLQQPQPKINNDPFDIF 873
            .:..|:..|.||.:..::|| ......|.||:.:.:.:..:               :|.|    |
Mouse   669 ATTTPSGSPRTSQQNVSNASEGSTWNPFDDDNFSKLTAEEL---------------LNKD----F 714

  Fly   874 GSVDQGGVP--------SMKPSGFPPFVGSLPTFVAQPAATTNPSPTHPARASADPFANIAD--- 927
            ..:.:|.:|        |:.| ||.|..|...|..:..|.|........|..|..|..:::|
Mouse   715 AKLGEGKLPEKLGGSAESLIP-GFQPTQGDAFTTPSFSAGTAEKRKGGQAVDSGIPLLSVSDPFI 778

  Fly   928 ----------LATGLNLNFNRSTLSGKSPVNTS---PQPTQFSSPTHKPSPSSQPQATFM----- 974
                      |..||           ||| :||   |.....:.|....|.:...:|...
Mouse   779 PLQVPDAPEKLIEGL-----------KSP-DTSLLLPDLLPMTDPFGSTSDAVIDKADVAVESLI 831

  Fly   975 --HTPPTPQTLPSTSSIRTPTQPQAVPAQ---------SRPDYSRLHFDSQKAAQQPGTGGSKNS 1028
              ..||..|.|||.:...|..:..::..:         |.|....|...:..|...|....:::|
Mouse   832 PGLEPPVAQRLPSQTESVTSNRTDSLTGEDSLLDCSLLSNPTAGLLEEFAPIALSAPTHKAAEDS 896

  Fly  1029 DIFADILGQQGYSFGSKMNQCPRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTV 1093
            ::.:..    |.:.||          |...||.|   ||..|.|.:.|.|.:.:...  |.:.||
Mouse   897 NLISGF----GVAEGS----------EKVAEDEF---DPIPVLITKNTQGLQRDPSP--CPVITV 942

  Fly  1094 LWDNAKWQRCEMSTMVTPTEVKKAYRRACLAVHPDKHNGTENEEIAK------LIFMELNNAWTD 1152
                 :..:..|.|...|     .|...|.|......|...::.:|:      ..|.......||
Mouse   943 -----EHFKESMGTKGLP-----LYPDPCRAPGTKTQNTLASDSLAREGPSSNSSFHSSEEEGTD 997

  Fly  1153 FEND 1156
            .|.|
Mouse   998 LEGD 1001

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357	96/278 (35%)
		S_TKc	51..317	CDD:214567	96/267 (36%)
		PTEN_C2	581..711	CDD:287393	18/147 (12%)
		DnaJ	<1110..1150	CDD:197617	7/45 (16%)
Aak1	XP_036022028.1	STKc_NAK_like	42..316	CDD:270939	96/300 (32%)
		PHA03378	<296..>429	CDD:223065	46/250 (18%)
		BMP2K_C	1085..1297	CDD:405873
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1989
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D826336at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820