DRSC/TRiP Functional Genomics Resources

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Protein Alignment aux and TNS2

DIOPT Version :10

Sequence 1:NP_649438.1 Gene:aux / 40527 FlyBaseID:FBgn0037218 Length:1165 Species:Drosophila melanogaster
Sequence 2:NP_001403133.1 Gene:TNS2 / 23371 HGNCID:19737 Length:1418 Species:Homo sapiens


Alignment Length:795 Identity:169/795 - (21%)
Similarity:271/795 - (34%) Gaps:261/795 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   397 TKVMQTMQQSLA-------RNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQ 454
            :|...|:.:|.:       |.|||::::|.|||....|:...|..:: .::.::...|:|:. ..
Human   109 SKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHR-GHLRELAHVLQSKH-RD 171

  Fly   455 KLSIYNFGQRTE--PRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQ 517
            |..::|..::..  .||.|.|:.      :|.|:.|||.|..|.::...|..:|:|||:.||::.
Human   172 KYLLFNLSEKRHDLTRLNPKVQD------FGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLY 230

  Fly   518 -TGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRH-----TINLRPSEFRYLYYFGDIL-- 574
             .|:.|  ....::.|.:.|:.:....:.|:....:::.     ...|:||:.||:.||..:|  
Human   231 CKGNKG--KLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYISYFSGLLSG 293

  Fly   575 ----RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAG 635
                ..:||..||   .|:     |:....:...|.:.::::|.:..|:      |.....:.||
Human   294 SIRMNSSPLFLHY---VLI-----PMLPAFEPGTGFQPFLKIYQSMQLV------YTSGVYHIAG 344

  Fly   636 PGKIVLPINLTAC----GDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDD 696
            ||...|.|:|...    |||.|..:|  ||........:.:.||:|..|..|:  :||....||:
Human   345 PGPQQLCISLEPALLLKGDVMVTCYH--KGGRGTDRTLVFRVQFHTCTIHGPQ--LTFPKDQLDE 405

  Fly   697 LPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTR 761
            ....|    ||....|:....|.||...|    .:.|:..|:.          .:|...|:|:.|
Human   406 AWTDE----RFPFQASVEFVFSSSPEKIK----GSTPRNDPSV----------SVDYNTTEPAVR 452

  Fly   762 -----------SSPPPGARKSDRVSSPLVLPDVTETAHEL----------------PSPMPEPSP 799
                       .....||:.:.||...|     |.|...|                |:|.|||.|
Human   453 WDSYENFNQHHEDSVDGAQAACRVGGSL-----THTRGPLDGSPYAQVQRPPRQTPPAPSPEPPP 512

  Fly   800 PIDL---------LNLNQQP-SDVPAADPLTSAKPSTDASFD-LLGAFG---------------- 837
            |..|         ..|..:| ::.|...|.|:|:..   ..| |||..|                
Human   513 PPMLSVSSDSGHSSTLTTEPAAESPGRPPPTAAERQ---ELDRLLGGCGVASGGRGAGRETAILD 574

  Fly   838 DDDSTGIGSAPIPDILP--PPPLQQPQPKINNDPFDIFGSVDQG-----GVPS---MKPSG---- 888
            |::...:|..|...:.|  .|.|.:            ..|..||     |||:   .:|.|    
Human   575 DEEQPTVGGGPHLGVYPGHRPGLSR------------HCSCRQGYREPCGVPNGGYYRPEGTLER 627

  Fly   889 ----FPPFVGSLPTFVAQPAATTNPSPTHPARASADPFANIADLATGLNLNFNRSTLSGKSPVNT 949
                :..:.|               ||...|.||.:.......|:.||                 
Human   628 RRLAYGGYEG---------------SPQGYAEASMEKRRLCRSLSEGL----------------- 660

  Fly   950 SPQPTQFSSPTHKPSPSSQP---QATFMHTPPTPQTLPSTS---SIRTPTQ-------------- 994
            .|.|.:...|.........|   :...:..|..|...|..:   .:..||.              
Human   661 YPYPPEMGKPATGDFGYRAPGYREVVILEDPGLPALYPCPACEEKLALPTAALYGLRLEREAGEG 725

  Fly   995 -------------------PQAVPA-----QSRPDYSRLHFDSQKAAQQPGTGGSKNSDIFADIL 1035
                               |..:||     ...||||.|         :|...|.:         
Human   726 WASEAGKPLLHPVRPGHPLPLLLPACGHHHAPMPDYSCL---------KPPKAGEE--------- 772

  Fly  1036 GQQGYSFGSKMNQCP 1050
            |.:|.|:    ..||
Human   773 GHEGCSY----TMCP 783

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
auxNP_649438.1 Protein Kinases, catalytic domain 49..326 CDD:473864
PTP_auxilin-like 404..573 CDD:350361 45/183 (25%)
PTEN_C2 581..711 CDD:463081 34/133 (26%)
PHA03247 <698..1037 CDD:223021 83/454 (18%)
Herpes_BLLF1 <882..>999 CDD:282904 22/166 (13%)
DnaJ <1110..1150 CDD:99751
TNS2NP_001403133.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..35
C1_TNS2 30..83 CDD:410437
PTP_tensin-2 132..290 CDD:350410 41/167 (25%)
PTEN_C2 297..424 CDD:463081 37/148 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 571..591 3/19 (16%)
PHA03247 <780..1137 CDD:223021 2/4 (50%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 821..1107
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1120..1139
SH2_Tensin_like 1145..1258 CDD:198181
PTB_tensin 1282..1414 CDD:269924
Blue background indicates that the domain is not in the aligned region.

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