Protein Alignment aux and AAK1

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_001413674.1
• Gene: AAK1 / 22848
• HGNCID: 19679
• Length: 1132
• Species: Homo sapiens
• Alignment Length: 1228
• Identity: 278/1228 - (22%)
• Similarity: 432/1228 - (35%)
• Gaps: 318/1228 - (25%)

  Fly    12 YFSSSEVNGAAGNGAPEALGG----RLDNDFVGQVVEVAGHRLRIKCVIAEGGYAFVYVAQDVQT 72
            :|.|....|.:|.|:..:.||    .|.:.::|:|..:...::.:..|:||||:|.|::.: ...
Human     4 FFDSRREQGGSGLGSGSSGGGGSTSGLGSGYIGRVFGIGRQQVTVDEVLAEGGFAIVFLVR-TSN 67

  Fly    73 GTEYALKRLIGADMQASTAIINEINIHKQLSGHENIVAFVGSSYTAPSTQLGAQYLLLTELCKGG 137
            |.:.||||:...:.........||.|.:.||||:|||.::.||....|:....:.|:|.:.|:||
Human    68 GMKCALKRMFVNNEHDLQVCKREIQIMRDLSGHKNIVGYIDSSINNVSSGDVWEVLILMDFCRGG 132

  Fly   138 SLVDCFRTN-NAPFNPTCVLRIFYQMARAVASLHSQSPPIAHRDIKIENFLIGNDKQIKLCDFGS 201
            .:|:..... ...|....||:||.....|||.||....||.|||:|:||.|:.:.....||||||
Human   133 QVVNLMNQRLQTGFTENEVLQIFCDTCEAVARLHQCKTPIIHRDLKVENILLHDRGHYVLCDFGS 197

  Fly   202 ASTEVLSPTFEWSANQRSMLEDQLNTVTTPMYRSPEMLDTWSNNPIGPKVDIWALGCILYFLCYR 266
            |:.:..:|..|..    :.:||::...||..||:|||::.:|...|..|.|||||||:||.|||.
Human   198 ATNKFQNPQTEGV----NAVEDEIKKYTTLSYRAPEMVNLYSGKIITTKADIWALGCLLYKLCYF 258

  Fly   267 KHPYEDGGKLRIINANYMLPPDPQY-QCFSDIIRGCLKVNPFERLDITMVLEGLAALAETHNWSL 330
            ..|:.: .::.|.:.|:.:|.:.:| |....:||..|:.:|.:|.||..|......|       |
Human   259 TLPFGE-SQVAICDGNFTIPDNSRYSQDMHCLIRYMLEPDPDKRPDIYQVSYFSFKL-------L 315

  Fly   331 KGPLDLHIMPIESLPAE--SPLKSSAYSEVYTEP---LSAAIPSSYNGHGSLLSSLRGGAGTLLK 390
            |....:..:....:||:  .|:|:|..:...|:|   |:..||::   ..|:....|..||....
Human   316 KKECPIPNVQNSPIPAKLPEPVKASEAAAKKTQPKARLTDPIPTT---ETSIAPRQRPKAGQTQP 377

  Fly   391 N-----IKDTST-----KVMQTMQQSLARNDLDISHITSRILVMPCPSDGFEST----------- 434
            |     |:...|     .|....|.:.:.|...:.....:......||.....|
Human   378 NPGILPIQPALTPRKRATVQPPPQAAGSSNQPGLLASVPQPKPQAPPSQPLPQTQAKQPQAPPTP 442

  Fly   435 YKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGCPQAHAPNLQGL---- 495
            .:|.:.:...|..:::..||........|:.:.:.|||.:...||:.|...||.....|.:
Human   443 QQTPSTQAQGLPAQAQATPQHQQQLFLKQQQQQQQPPPAQQQPAGTFYQQQQAQTQQFQAVHPAT 507

  Fly   496 -------FTVSAD-------MYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREP--- 543
                   |.|.:.       |.||.....:..  .|.......||......:...|.|.::|
Human   508 QKPAIAQFPVVSQGGSQQQLMQNFYQQQQQQQ--QQQQQQQLATALHQQQLMTQQAALQQKPTMA 570

  Fly   544 ------------------EDAVQVFAVKRH----------------TINLRP------------- 561
                              ::..|:.|..|.                ..:|.|
Human   571 AGQQPQPQPAAAPQPAPAQEPAQIQAPVRQQPKVQTTPPPAVQGQKVGSLTPPSSPKTQRAGHRR 635

  Fly   562 --SEFRYLYYFGDILRPTPLLPHYKNTTLV-----------SLSCQPVPRMTKARDGCRIY---- 609
              |:..:...||        :|..|:|.|:           |.|....|..:.......:|
Human   636 ILSDVTHSAVFG--------VPASKSTQLLQAAAAEASLNKSKSATTTPSGSPRTSQQNVYNPSE 692

  Fly   610 ---MEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVRPQGLKIC 671
               ...:.:.|....|.::.......:.|.||  .|..|....:..:      .|....||....
Human   693 GSTWNPFDDDNFSKLTAEELLNKDFAKLGEGK--HPEKLGGSAESLI------PGFQSTQGDAFA 749

  Fly   672 QFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKP---------- 726
            ...|:.|           |:...:..|.|......|..||.:........||..|
Human   750 TTSFSAG-----------TDLQRESNPCPVITVEHFKESLGVKGLPLYPDPSRVPGTKTQNNLES 803

  Fly   727 PWMPAKPKRSPAALFSS-----DLEYAEMLDNFVTKPSTRSS--------PPPGARKSDRVSSPL 778
            .::......|.::..||     ||| .:|||...::|....|        ||||....   :.|.
Human   804 DYLARDGPSSNSSFHSSEEEGTDLE-GDMLDCSGSRPLLMESEEEDESCRPPPGKLGG---AVPF 864

  Fly   779 VLPDVTETAHELPSPMPEPSPPIDLLNLNQ-QPSDVPAADPLTSAKPSTDASFDLLGAFGDDDST 842
            ..|:|:          ||.:..:.....|| |....||.|.|:.
Human   865 APPEVS----------PEQAKTVQGGRKNQFQAFTQPATDGLSE--------------------- 898

  Fly   843 GIGSAPIPDILPPPPLQQPQPKINNDPFDIFGSVDQGGVPSMKPSGFP---------PFV----- 893
                   ||:....|.:  ..::.||..|||.........||.||. |         ||.
Human   899 -------PDVFAIAPFR--SSRVPNDDMDIFSKAPFVSKSSMAPSQ-PEESDVFLRAPFTKKKSM 953

  Fly   894 ----------GSLPTFVAQPAATTN-PSPTHPARA--------------------------SADP 921
                      ..||......:.|.: |.|....||                          :||.
Human   954 EELTVIQCTSQELPAQTGLLSQTGDVPLPAGRERAVYTSVQAQYSTAGFVQQSNLLSHSVQAADH 1018

  Fly   922 FANIAD----LATGLNLN-------FNRSTLSGKSPVNTSP-QPTQFS------SPTHKPSPSSQ 968
            ..:|:.    |.:|.:.|       ..:..:||  |:...| :|...|      ||..:|||.:|
Human  1019 LDSISPRGSCLESGGHSNDRNKGPQLQKEAVSG--PMAGKPFRPQSLSKYSRHYSPEDEPSPEAQ 1081

  Fly   969 PQATFMHTPPT-PQTLPSTSSI-----RTPTQPQAVPAQSRPDYSRLHFDSQKAAQQP 1020
            |.|.:.....| .|::..:.||     ||...|.|.|....|      |.| |:.::|
Human  1082 PIAAYKIVSQTNKQSIAGSVSITSLSSRTTELPAADPFALAP------FPS-KSGKKP 1132

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864	98/278 (35%)
		PTP_auxilin-like	404..573	CDD:350361	38/249 (15%)
		PTEN_C2	581..711	CDD:463081	24/147 (16%)
		PHA03247	<698..1037	CDD:223021	91/422 (22%)
		Herpes_BLLF1	<882..>999	CDD:282904	42/191 (22%)
		DnaJ	<1110..1150	CDD:99751
AAK1	NP_001413674.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		6/20 (30%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	327..493		34/168 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	665..702		4/36 (11%)