DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment aux and Tns2

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	XP_030104299.1	Gene:	Tns2 / 209039	MGIID:	2387586	Length:	1408	Species:	Mus musculus

Alignment Length:	787	Identity:	173/787 - (21%)
Similarity:	276/787 - (35%)	Gaps:	223/787 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   397 TKVMQTMQQSLA-------RNDLDISHITSRILVMPCPSDGFESTYKTNNIEDVRLSLESRFVPQ 454
            :|...|:.:|.:       |.|||::::|.|||....|:...|..:: .::.::...|:|:. ..
Mouse   110 SKQRSTLPRSFSLDPLMERRWDLDLTYVTERILAAAFPARPDEQRHR-GHLRELAHVLQSKH-RD 172

  Fly   455 KLSIYNFGQRTE--PRLPPPVRTVEAGSVYGCPQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQ 517
            |..::|..::..  .||.|.|:.      :|.|:.|||.|..|.::...|..:|:|||:.||::.
Mouse   173 KYLLFNLSEKRHDLTRLNPKVQD------FGWPELHAPPLDKLCSICKAMETWLSADPQHVVVLY 231

  Fly   518 TGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRH-----TINLRPSEFRYLYYFGDIL--- 574
            ...|.| ....::.|.:.|:.:....:.|:....:::.     ...|:||:.||:.||..:|
Mouse   232 CKGSKG-KLGVIVSAYMHYSKISAGADQALATLTMRKFCEDKVATELQPSQRRYVSYFSGLLSGS 295

  Fly   575 ---RPTPLLPHYKNTTLVSLSCQPVPRMTKARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQ-AG 635
               ..:||..||...        ||....:...|.:.::::|.:..|:.::       .:|: ||
Mouse   296 IRMNSSPLFLHYVFV--------PVLPAFEPNTGFQPFLKIYQSMQLVYTS-------GVYRIAG 345

  Fly   636 PGKIVLPINLTAC----GDVTVVLFHARKGMVRPQGLKICQFQFNTGFIPEPETLITFTNQDLDD 696
            ||...|.|:|...    |||.|..:|  ||........:.:.||:|..|  ..:.:||....||:
Mouse   346 PGPQQLCISLEPALLLKGDVMVTCYH--KGGQGTDRTLVFRVQFHTCTI--HGSRLTFPKDQLDE 406

  Fly   697 LPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKRSPAALFSSDLEYAEMLDNFVTKPSTR 761
            ....|    ||....|:....|.||...|    ...|:..|:.          .:|...|:|:.|
Mouse   407 AWADE----RFPFQASVEFVFSSSPEKVK----GNTPRNDPSV----------SVDYNTTEPAVR 453

  Fly   762 --SSPPPGARKSDRVSSPLV----------------LPDVTETAHELPSPMPE-PSPPIDLLNLN 807
              |.........|.|...|.                :|..|.     |:|.|| |.||  :|:::
Mouse   454 WDSYENFNQHHEDSVDGALAHTRGPLDGSPYAQVQRVPRQTP-----PAPSPELPPPP--MLSVS 511

  Fly   808 -----------QQPSDVPAADPLTSAKPSTDASFD-LLGAFGDDDSTGIGSAPIPDILPPPPLQQ 860
                       :..::.|...|.|:|:..   ..| |||..| ..|.|.|:.....||.    .:
Mouse   512 SDSGHSSTLTTEHTAESPGRPPPTAAERQ---ELDRLLGGCG-VASAGRGAGRETAILD----DE 568

  Fly   861 PQPKINNDPFDIFGSVDQG-----------------------GVPS---MKPSGF-----PPFVG 894
            .||.:.       |.:..|                       |||:   .:|.|.     ||:.|
Mouse   569 EQPSVG-------GGLHLGMYSGHRPGLSRRCSCRQGFREPCGVPNGSYYRPEGTLERRRPPYGG 626

  Fly   895 --------------------SLP----------------TFVAQPAATTN----PSPTHPARASA 919
                                ||.                .|..:||....    ..|..||..|.
Mouse   627 YEGHPQGYAEASVEKRRLCRSLSEGPYPYAPELGKPANGDFGYRPAGYREVVILEDPGVPALCSC 691

  Fly   920 DPFANIADLATG--LNLNFNRSTLSGKSPVNTSP--QPTQFSSPTHKPSPSSQPQATFMHTPPTP 980
            ........|.|.  ..|...|....|.|.....|  .|.:   |.| |.|...|.....|.|
Mouse   692 PACEEKLALPTAALYGLRLEREAAEGWSSEVGKPLLHPVR---PGH-PLPLLVPACGHHHAP--- 749

  Fly   981 QTLPSTSSIRTPTQPQ--------AVPAQSRPDYSRLHFDSQKAAQQPGTGGSKNSDIFADILGQ 1037
              :|....::.|...:        ||.::.|..:|     ...|....|.||:..|  :....|:
Mouse   750 --MPDYGCLKPPKVGEEGHEGCSYAVCSEGRYGHS-----GYPALVTYGYGGAVPS--YCPAYGR 805

  Fly  1038 QGYSFGS 1044
            ..:|.||
Mouse   806 APHSCGS 812

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	33/134 (25%)
		DnaJ	<1110..1150	CDD:197617
Tns2	XP_030104299.1	C1	33..80	CDD:237996
		PTP_DSP_cys	133..291	CDD:391942	41/166 (25%)
		PTEN_C2	298..425	CDD:371036	36/149 (24%)
		PHA03247	<726..1124	CDD:223021	23/103 (22%)
		SH2_Tensin_like	1135..1248	CDD:198181
		PTB_tensin	1272..1404	CDD:269924
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG2283
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810