DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment aux and dnj-25

DIOPT Version :9

Sequence 1:	NP_649438.1	Gene:	aux / 40527	FlyBaseID:	FBgn0037218	Length:	1165	Species:	Drosophila melanogaster
Sequence 2:	NP_001360578.1	Gene:	dnj-25 / 180356	WormBaseID:	WBGene00001043	Length:	786	Species:	Caenorhabditis elegans

Alignment Length:	888	Identity:	217/888 - (24%)
Similarity:	358/888 - (40%)	Gaps:	237/888 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   377 LLSSLRGGAGTLLKNIKDTSTKVMQTMQQSLAR-------NDLDISHITSRILVMPCPSDGFEST 434
            |:.||:|...:|.||:|:....:::..:...|.       :|:.::.:|:||::.       ::.
Worm    24 LMESLKGQGSSLAKNLKNFGKSLVKEHKSQGATTPPEHRDDDIRLTWLTNRIVLA-------DTL 81

  Fly   435 YKTNNIEDVRLSLESRFVPQKLSIYNF---GQRTEP-RLPPPVRTVEA--GSVY--GCPQAHAPN 491
            :|:   ::..|..|:..|.:.:....:   ....|| :|....::|..  ||..  |.|:  .|.
Worm    82 HKS---KEGLLKAETAVVREMIDCQPYVVVNVHAEPLKLDGYAKSVHVPLGSAAKGGLPK--YPT 141

  Fly   492 LQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREPEDAVQVFAVKRHT 556
            :|.|..: .:.|..|..| .::||....::...|||..:.|....:.:.....|::
Worm   142 IQALVPI-LNEYCLLTND-AAIVIFGNDENVQITAAFCLIASRTISRVSEFMSDSL--------- 195

  Fly   557 INLRPSEFRYLYYFGDILRPTPLLPH--YKNTTLVSLSCQPVPRMTKARDGC---RIYME---VY 613
                |:.|..|          |:..|  .:.|..|   |:...|..:.:.|.   :|.:|   :.
Worm   196 ----PNRFDRL----------PVTYHLFLEQTKHV---CKYHARRQQLQSGAILNQIILEPGTLL 243

  Fly   614 CNGNLLLSTLQDYEKMRLYQAG-------PGKIVLPINLTACGDVTVVLFHARKGMVRPQGLKIC 671
            .:|:|.::..|...::::.:..       .|::|..:..|...| .||:|..:|..|:.   .|.
Worm   244 IDGDLYVAIQQGINQLKVVEFSANSCRNRQGQLVFNMESTETVD-DVVIFLGKKSDVKH---PIL 304

  Fly   672 QFQFNTGFIPEPETLITFTNQDLDDLPDPEQVTPRFCVSLSLAVTDSESPPSHKPPWMPAKPKRS 736
            ..:|||..:...::.|.||:.::|             ||..:|..            ||.:..|
Worm   305 ASKFNTQLLHSEDSSIIFTSSEMD-------------VSKMIASA------------MPVQDLR- 343

  Fly   737 PAALFSSDLEYAEMLDNFVTKPSTRSSPPPGARKSDR-----VSSPLVLPDVTETAHELPSPMPE 796
                         |:.||    :||..|.....:.||     |.:...|.....:..::.|   |
Worm   344 -------------MIVNF----ATRRMPTLNTFQFDRYKLLCVRNDRELDGYQRSYGDVDS---E 388

  Fly   797 PSPPIDLLNLNQQPSDVPAADPLTSAKPSTDASFDLLGAFGD----------DDSTGIGSAPIPD 851
            ...||  |...:..|...||:  ||:  |....||.| .|.|          .|||
Worm   389 DESPI--LRSARSKSGTKAAE--TSS--SQGNFFDSL-QFEDRQEPHHFREQRDST--------- 437

  Fly   852 ILPPPPLQQPQPKINNDPFDIFGSVDQGGVPSMKPSGFPPFVGSLPTFVAQPAAT---------- 906
                  |......:.:...|:......||...:.|:...|.: |.||    ||::
Worm   438 ------LLDHHDDVTHHTADLLDGFTIGGTEKLSPANETPIL-SAPT----PASSDYDSMTSSQN 491

  Fly   907 -TNPSP--------------THPARASADPF------ANIADLATG--LNLNFNRSTLSGKSPVN 948
             .||||              :.||.|.:..|      ||:.|...|  :....:.|.||..||..
Worm   492 RRNPSPATAIDDLLGLGTETSAPAPAPSTHFNNSSSGANLVDFDLGAPIKPTSSASNLSTASPAT 556

  Fly   949 TS--------------PQPTQFSSPTHKPSPS---SQP------QATF----MHTPPTPQTLP-S 985
            :|              ||.|.....|..||.|   |:|      ||.|    .:.|...|..| :
Worm   557 SSWSNTDLLGGFSPMKPQTTSTPPNTRNPSASISDSKPVSQVNSQADFEAFLSNYPEQRQAAPQN 621

  Fly   986 TSSIRTPTQPQAVPAQSRPDYSRLHFDSQKAAQQPGTGGSKNS-DIFADILGQQGYSFGSKMNQC 1049
            |.::...||      |:||..:     .:.|.....||.:|.| |.|:|:|.|.|:....:.||
Worm   622 TQNVSQKTQ------QTRPQNT-----YKPAFGDAATGSAKVSMDAFSDLLNQGGFKPTQRENQ- 674

  Fly  1050 PRSINEMRKEDLFKDMDPKKVRIMEWTDGKKNNIRALLCSMHTVLWDNA-KWQRCEMSTMVTPTE 1113
            .:||..|.|.:..|::.|::::|.:||.||:.||||||.|:|.|||:.| :|.:..|..::||.:
Worm   675 KQSIGNMLKVEQSKNLTPEEIQIRDWTQGKERNIRALLGSLHNVLWEGADRWNQPSMGDLLTPDQ 739

  Fly  1114 VKKAYRRACLAVHPDKHNGTENEEIAKLIFMELNNAWTDFEND 1156
            :||.||:|||.|||||..|:.:..:||:.|.|||:|::.::||
Worm   740 IKKHYRKACLVVHPDKLTGSPHLSLAKMAFTELNDAYSKYQND 782

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	PKc_like	49..326	CDD:304357
		S_TKc	51..317	CDD:214567
		PTEN_C2	581..711	CDD:287393	29/144 (20%)
		DnaJ	<1110..1150	CDD:197617	21/39 (54%)
dnj-25	NP_001360578.1	Herpes_BLLF1	<466..>660	CDD:282904	53/209 (25%)
dnj-25	NP_001360578.1	DnaJ	735..782	CDD:197617	22/46 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166608
Domainoid	1	1.000	53	1.000	Domainoid score	I7641
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001565
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23172
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030