Protein Alignment aux and daf-18

DIOPT Version :10

• Sequence 1: NP_649438.1
• Gene: aux / 40527
• FlyBaseID: FBgn0037218
• Length: 1165
• Species: Drosophila melanogaster
• Sequence 2: NP_499926.1
• Gene: daf-18 / 176869
• WormBaseID: WBGene00000913
• Length: 962
• Species: Caenorhabditis elegans
• Alignment Length: 710
• Identity: 136/710 - (19%)
• Similarity: 230/710 - (32%)
• Gaps: 240/710 - (33%)

  Fly   361 EPLSAAIPSSYNGHGSLLSSLRGGAGTLLKNIKDTSTKVMQTMQQSLARNDLDISHITSRILVMP 425
            :|....:...|  |.|::..:|....|.:      |:...:|..|::   |||.::||.||:.:.
 Worm    27 QPGEPRVSEPY--HNSIVERIRHIFRTAV------SSNRCRTEYQNI---DLDCAYITDRIIAIG 80

  Fly   426 CPSDGFESTYKTNNIEDVRLSLESRFVPQKLSIYNFGQRTEPRLPPPVRTVEAGSVYGC------ 484
            .|:.|.|:.::.:.::..:. |..|.....:.::|               :..|..|..
 Worm    81 YPATGIEANFRNSKVQTQQF-LTRRHGKGNVKVFN---------------LRGGYYYDADNFDGN 129

  Fly   485 ------PQAHAPNLQGLFTVSADMYNFLNADPKSVVIVQTGDSGGCTAATVICALLMYADLLREP 543
                  ...|.|:|:.:.....:...:|.||.|.|:.|......|.| ..:|||||:|.:....|
 Worm   130 VICFDMTDHHPPSLELMAPFCREAKEWLEADDKHVIAVHCKAGKGRT-GVMICALLIYINFYPSP 193

  Fly   544 EDAVQVFAVKRHTINLR----PSEFRYLYYFGDI----LRPTPLLPHYKNTTLVSLSCQPVPRMT 600
            ...:..:::.| |.|.:    ||:.||:||:..:    |...||     ...|:.:..:..|:..
 Worm   194 RQILDYYSIIR-TKNNKGVTIPSQRRYIYYYHKLRERELNYLPL-----RMQLIGVYVERPPKTW 252

  Fly   601 KARDGCRIYMEVYCNGNLLLSTLQDYEKMRLYQAGPGKIVLPINLTACGDVTVVLFHARKGMVRP 665
            ..  |.:|.:|| .||:.:           |::..| .|:...|            |.|:   |.
 Worm   253 GG--GSKIKVEV-GNGSTI-----------LFKPDP-LIISKSN------------HQRE---RA 287

  Fly   666 QGLKICQF--QFNT------GFIPE-------PETLITFTNQDLDDLPDPEQVTPRFCVSLSLAV 715
            ..|..|..  :|:|      ||:.:       ||....|...|:       ::..|   .:....
 Worm   288 TWLNNCDTPNEFDTGEQKYHGFVSKRAYCFMVPEDAPVFVEGDV-------RIDIR---EIGFLK 342

  Fly   716 TDSESPPSHKPPWMPAKPKRSPAALFSSD-------LEYAEMLDNFVTKPSTRSSPPPGARKSDR 773
            ..|:....|  .|.        ..:|:.|       .||.:....:: ...|......|.|:::
 Worm   343 KFSDGKIGH--VWF--------NTMFACDGGLNGGHFEYVDKTQPYI-GDDTSIGRKNGMRRNE- 395

  Fly   774 VSSPLVLPDVTETAHELPSPMPEPSPPIDLLNLNQQPSDVPAADPLTS----------------- 821
              :|:...| .||.:|..||....:||    .|.:..::..|.:..|:
 Worm   396 --TPMRKID-PETGNEFESPWQIVNPP----GLEKHITEEQAMENYTNYGMIPPRYTISKILHEK 453

  Fly   822 -------------AKPSTDASFDLLGAFGDDDSTGIGSAPIPDILPPPPLQQPQPKINNDPFDIF 873
                         ..|..|.|:...|..|  |..|:|.                      ||:|
 Worm   454 HEKGIVKDDYNDRKLPMGDKSYTESGKSG--DIRGVGG----------------------PFEI- 493

  Fly   874 GSVDQGGVPSMKPSGFPPFVGSLPTFVAQPAATT----NPSPTHPARASADP-----------FA 923
                        |......|.:.|.:....|..:    |....|......|.           |.
 Worm   494 ------------PYKAEEHVLTFPVYEMDRALKSKDLNNGMKLHVVLRCVDTRDSKMMEKSEVFG 546

  Fly   924 NIADLATGLNLNFNRST--LSGKSPVNTS--PQPTQFSSPTHKPSPSSQPQATFMHTPPT 979
            |:|        ..|.||  |...:.:|..  |:|..|.|           :...||.||:
 Worm   547 NLA--------FHNESTRRLQALTQMNPKWRPEPCAFGS-----------KGAEMHYPPS 587

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
aux	NP_649438.1	Protein Kinases, catalytic domain	49..326	CDD:473864
		PTP_auxilin-like	404..573	CDD:350361	43/184 (23%)
		PTEN_C2	581..711	CDD:463081	26/144 (18%)
		PHA03247	<698..1037	CDD:223021	57/338 (17%)
		Herpes_BLLF1	<882..>999	CDD:282904	23/117 (20%)
		DnaJ	<1110..1150	CDD:99751
daf-18	NP_499926.1	PTP_PTEN	68..226	CDD:350359	40/175 (23%)
		PTEN_C2	233..>364	CDD:463081	33/185 (18%)